Details for: LRRC8D

Gene ID: 55144

Symbol: LRRC8D

Ensembl ID: ENSG00000171492

Description: leucine rich repeat containing 8 VRAC subunit D

Associated with

Other Information

Genular Protein ID: 1678286665

Symbol: LRC8D_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 22532330

Title: LRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell-cell communication.

PubMed ID: 22532330

DOI: 10.1002/bies.201100173

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24782309

Title: The protein synthesis inhibitor blasticidin S enters mammalian cells via leucine-rich repeat-containing protein 8D.

PubMed ID: 24782309

DOI: 10.1074/jbc.m114.571257

PubMed ID: 24790029

Title: Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.

PubMed ID: 24790029

DOI: 10.1126/science.1252826

PubMed ID: 26530471

Title: Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs.

PubMed ID: 26530471

DOI: 10.15252/embj.201592409

PubMed ID: 26824658

Title: LRRC8 proteins form volume-regulated anion channels that sense ionic strength.

PubMed ID: 26824658

DOI: 10.1016/j.cell.2015.12.031

PubMed ID: 28193731

Title: Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels.

PubMed ID: 28193731

DOI: 10.1242/jcs.196253

PubMed ID: 33171122

Title: LRRC8A:C/E heteromeric channels are ubiquitous transporters of cGAMP.

PubMed ID: 33171122

DOI: 10.1016/j.molcel.2020.10.021

PubMed ID: 32415200

Title: Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation.

PubMed ID: 32415200

DOI: 10.1038/s42003-020-0951-z

Sequence Information:

  • Length: 858
  • Mass: 98201
  • Checksum: 52A8B6EEF6F0FE2B
  • Sequence:
  • MFTLAEVASL NDIQPTYRIL KPWWDVFMDY LAVVMLMVAI FAGTMQLTKD QVVCLPVLPS 
    PVNSKAHTPP GNAEVTTNIP KMEAATNQDQ DGRTTNDISF GTSAVTPDIP LRATYPRTDF 
    ALPNQEAKKE KKDPTGRKTN LDFQQYVFIN QMCYHLALPW YSKYFPYLAL IHTIILMVSS 
    NFWFKYPKTC SKVEHFVSIL GKCFESPWTT KALSETACED SEENKQRITG AQTLPKHVST 
    SSDEGSPSAS TPMINKTGFK FSAEKPVIEV PSMTILDKKD GEQAKALFEK VRKFRAHVED 
    SDLIYKLYVV QTVIKTAKFI FILCYTANFV NAISFEHVCK PKVEHLIGYE VFECTHNMAY 
    MLKKLLISYI SIICVYGFIC LYTLFWLFRI PLKEYSFEKV REESSFSDIP DVKNDFAFLL 
    HMVDQYDQLY SKRFGVFLSE VSENKLREIS LNHEWTFEKL RQHISRNAQD KQELHLFMLS 
    GVPDAVFDLT DLDVLKLELI PEAKIPAKIS QMTNLQELHL CHCPAKVEQT AFSFLRDHLR 
    CLHVKFTDVA EIPAWVYLLK NLRELYLIGN LNSENNKMIG LESLRELRHL KILHVKSNLT 
    KVPSNITDVA PHLTKLVIHN DGTKLLVLNS LKKMMNVAEL ELQNCELERI PHAIFSLSNL 
    QELDLKSNNI RTIEEIISFQ HLKRLTCLKL WHNKIVTIPP SITHVKNLES LYFSNNKLES 
    LPVAVFSLQK LRCLDVSYNN ISMIPIEIGL LQNLQHLHIT GNKVDILPKQ LFKCIKLRTL 
    NLGQNCITSL PEKVGQLSQL TQLELKGNCL DRLPAQLGQC RMLKKSGLVV EDHLFDTLPL 
    EVKEALNQDI NIPFANGI

Genular Protein ID: 316276679

Symbol: B3KRU1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 858
  • Mass: 98273
  • Checksum: AB094C53070C0CCB
  • Sequence:
  • MFTLAEVASL NDIQPTYRIL KPWWDVFMDY LAVVMLMVAI FAGTMQLTKD QVVCLPVLPS 
    PVNSKAHTPP GNAEVTTNIP KMEAATNQDQ DGRTTNDISF GTSAVTPDIP LRATYPRTDF 
    ALPNQEAKKE KKDPTGRKTN LDFQQYVFIN QMCYHLALPW YSKYFPYLAL IHTIILMVSS 
    NFWFKYPKTC SKVEHFVSIL EKCFESPWTT KALSETACED SEENKQRITG AQTLPKHVST 
    SSDEGSPSAS TPMINKTGFK FSAEKPVIEV PSMTILDKKD GEQAKALFEK VRKFRAHVED 
    SDLIYKLYVV QTVIKTAKFI FILCYTANFV NAISFEHVCK PKVEHLIGYE VFECTHNMAY 
    MLKKLLISYI SIICVYGFIC LYTLFWLFRI PLKEYSFEKV REESSFSDIP DVKNDFAFLL 
    HMVDQYDQLY SKRFGVFLSE VSENKLREIS LNHEWTFEKL RQHISRNAQD KQELHLFMLS 
    GVPDAVFDLT DLDVLKLELI PEAKIPAKIS QMTNLQELHL CHCPAKVEQT AFSFLRDHLR 
    CLHVKFTDVA EIPAWVYLLK NLRELYLIGN LNSENNKMIG LESLRELRHL KILHVKSNLT 
    KVPSNITDVA PHLTKLVIHN DGTKLLVLNS LKKMMNVAEL ELQNCELERI PHAIFSLSNL 
    QELDLKSNNI RTIEEIISFQ HLKRLTCLKL WHNKIVTIPP SITHVKNLES LYFSNNKLES 
    LPVAVFSLQK LRCLDVSYNN ISMIPIEIGL LQNLQHLHIT GNKVDILPKQ LFKCIKLRTL 
    NLGQNCITSL PEKVGQLSQL TQLELKGNCL DRLPAQLGQC RMLKKSGLVV EDHLFDTLPL 
    EVKEALNQDI NIPFANGI

Genular Protein ID: 3722641158

Symbol: Q96GG5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 143
  • Mass: 16029
  • Checksum: A879FB85F13CAE3B
  • Sequence:
  • MVSSNFWFKY PKTCSKVEHF VSILGKCFES PWTTKALSET ACEDSEENKQ RITGAQTLPK 
    HVSTSSDEGS PSASTPMINK TGFKFSAEKP VIEVPSMTIL DKKDGEQAKA LFEKVRKFRA 
    HVEDSDLIYK LYVVQTASPF PNQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.