Details for: PRMT6
Associated with
Other Information
Genular Protein ID: 4174878418
Symbol: ANM6_HUMAN
Name: Protein arginine N-methyltransferase 6
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11724789
Title: The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity.
PubMed ID: 11724789
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15334060
Title: DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo.
PubMed ID: 15334060
PubMed ID: 15596808
Title: Methylation of Tat by PRMT6 regulates human immunodeficiency virus type 1 gene expression.
PubMed ID: 15596808
PubMed ID: 16157300
Title: Protein arginine methyltransferase 6 specifically methylates the nonhistone chromatin protein HMGA1a.
PubMed ID: 16157300
PubMed ID: 16159886
Title: Dynamics of human protein arginine methyltransferase 1(PRMT1) in vivo.
PubMed ID: 16159886
PubMed ID: 16600869
Title: Arginine methylation regulates DNA polymerase beta.
PubMed ID: 16600869
PubMed ID: 17176473
Title: PRMT6 diminishes HIV-1 Rev binding to and export of viral RNA.
PubMed ID: 17176473
PubMed ID: 17415034
Title: Arginine methylation of the HIV-1 nucleocapsid protein results in its diminished function.
PubMed ID: 17415034
PubMed ID: 17267505
Title: Arginine methylation of the human immunodeficiency virus type 1 Tat protein by PRMT6 negatively affects Tat Interactions with both cyclin T1 and the Tat transactivation region.
PubMed ID: 17267505
DOI: 10.1128/jvi.01888-06
PubMed ID: 17898714
Title: Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive.
PubMed ID: 17898714
DOI: 10.1038/nature06166
PubMed ID: 18079182
Title: PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation.
PubMed ID: 18079182
DOI: 10.1101/gad.447007
PubMed ID: 18077460
Title: Arginine methylation of the histone H3 tail impedes effector binding.
PubMed ID: 18077460
PubMed ID: 18263580
Title: A kinetic study of human protein arginine N-methyltransferase 6 reveals a distributive mechanism.
PubMed ID: 18263580
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 19405910
Title: Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4.
PubMed ID: 19405910
DOI: 10.1042/bj20090268
PubMed ID: 19509293
Title: Thrombospondin-1 is a transcriptional repression target of PRMT6.
PubMed ID: 19509293
PubMed ID: 20047962
Title: Protein arginine methyltransferase 6 regulates multiple aspects of gene expression.
PubMed ID: 20047962
DOI: 10.1093/nar/gkp1203
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23866860
Title: Automethylation of protein arginine methyltransferase 6 (PRMT6) regulates its stability and its anti-HIV-1 activity.
PubMed ID: 23866860
PubMed ID: 26178996
Title: pUL69 of human cytomegalovirus recruits the cellular protein arginine methyltransferase 6 via a domain that is crucial for mRNA export and efficient viral replication.
PubMed ID: 26178996
DOI: 10.1128/jvi.01399-15
PubMed ID: 30420520
Title: Arginine methylation of SIRT7 couples glucose sensing with mitochondria biogenesis.
PubMed ID: 30420520
Sequence Information:
- Length: 375
- Mass: 41938
- Checksum: 40AAEC7342C08A38
- Sequence:
MSQPKKRKLE SGGGGEGGEG TEEEDGAERE AALERPRRTK RERDQLYYEC YSDVSVHEEM IADRVRTDAY RLGILRNWAA LRGKTVLDVG AGTGILSIFC AQAGARRVYA VEASAIWQQA REVVRFNGLE DRVHVLPGPV ETVELPEQVD AIVSEWMGYG LLHESMLSSV LHARTKWLKE GGLLLPASAE LFIAPISDQM LEWRLGFWSQ VKQHYGVDMS CLEGFATRCL MGHSEIVVQG LSGEDVLARP QRFAQLELSR AGLEQELEAG VGGRFRCSCY GSAPMHGFAI WFQVTFPGGE SEKPLVLSTS PFHPATHWKQ ALLYLNEPVQ VEQDTDVSGE ITLLPSRDNP RRLRVLLRYK VGDQEEKTKD FAMED
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.