APPL2 | ENSG00000136044 | NCBI 55198

Details for: APPL2

Gene ID: 55198

Symbol: APPL2

Ensembl ID: ENSG00000136044

Description: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2

Associated with

Adiponectin-activated signaling pathway
(GO:0033211)
Cell cycle
(GO:0007049)
Cellular response to hepatocyte growth factor stimulus
(GO:0035729)
Cold acclimation
(GO:0009631)
Cytoplasmic vesicle
(GO:0031410)
Diet induced thermogenesis
(GO:0002024)
Early endosome membrane
(GO:0031901)
Early phagosome
(GO:0032009)
Early phagosome membrane
(GO:0036186)
Endosome
(GO:0005768)
Endosome membrane
(GO:0010008)
Extracellular exosome
(GO:0070062)
Glucose homeostasis
(GO:0042593)
Identical protein binding
(GO:0042802)
Macropinosome
(GO:0044354)
Membrane
(GO:0016020)
Negative regulation of cellular response to insulin stimulus
(GO:1900077)
Negative regulation of cytokine production involved in inflammatory response
(GO:1900016)
Negative regulation of fatty acid oxidation
(GO:0046322)
Negative regulation of glucose import
(GO:0046325)
Negative regulation of neural precursor cell proliferation
(GO:2000178)
Negative regulation of neurogenesis
(GO:0050768)
Nucleus
(GO:0005634)
Phosphatidylinositol binding
(GO:0035091)
Phosphatidylserine binding
(GO:0001786)
Plasma membrane
(GO:0005886)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of fc-gamma receptor signaling pathway involved in phagocytosis
(GO:1905451)
Positive regulation of macropinocytosis
(GO:1905303)
Positive regulation of phagocytosis, engulfment
(GO:0060100)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein homotetramerization
(GO:0051289)
Protein import into nucleus
(GO:0006606)
Regulation of fibroblast migration
(GO:0010762)
Regulation of g1/s transition of mitotic cell cycle
(GO:2000045)
Regulation of innate immune response
(GO:0045088)
Regulation of toll-like receptor 4 signaling pathway
(GO:0034143)
Ruffle
(GO:0001726)
Ruffle membrane
(GO:0032587)
Signaling
(GO:0023052)
Signal transduction
(GO:0007165)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Vesicle
(GO:0031982)

Other Information

Proteins

DP13B_HUMAN

Genular Protein ID: 1728295984

Symbol: DP13B_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8NEU8 B7Z411 B7Z4B0 F5GZG0 F8W1P5 Q8N4R7 Q9NVL2

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11431708

Title: Disruption of the ProSAP2 gene in a t(12;22)(q24.1;q13.3) is associated with the 22q13.3 deletion syndrome.

PubMed ID: 11431708

DOI: 10.1086/321293

PubMed ID: 15016378

Title: APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment.

PubMed ID: 15016378

DOI: 10.1016/s0092-8674(04)00117-5

PubMed ID: 17030088

Title: APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex.

PubMed ID: 17030088

DOI: 10.1016/j.mce.2006.08.014

PubMed ID: 18034774

Title: Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides.

PubMed ID: 18034774

DOI: 10.1111/j.1600-0854.2007.00680.x

PubMed ID: 19433865

Title: Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.

PubMed ID: 19433865

DOI: 10.1074/jbc.m109.007237

PubMed ID: 21645192

Title: Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment.

PubMed ID: 21645192

DOI: 10.1111/j.1600-0854.2011.01226.x

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24879834

Title: The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle.

PubMed ID: 24879834

DOI: 10.2337/db14-0337

PubMed ID: 26583432

Title: APPL proteins promote TGFbeta-induced nuclear transport of the TGFbeta type I receptor intracellular domain.

PubMed ID: 26583432

DOI: 10.18632/oncotarget.6346

PubMed ID: 23055524

Title: Membrane curvature protein exhibits interdomain flexibility and binds a small GTPase.

PubMed ID: 23055524

DOI: 10.1074/jbc.m112.349803

Sequence Information:

Length: 664
Mass: 74493
Checksum: 359404B1CBA813DB
Sequence:

MPAVDKLLLE EALQDSPQTR SLLSVFEEDA GTLTDYTNQL LQAMQRVYGA QNEMCLATQQ 
LSKQLLAYEK QNFALGKGDE EVISTLHYFS KVVDELNLLH TELAKQLADT MVLPIIQFRE 
KDLTEVSTLK DLFGLASNEH DLSMAKYSRL PKKKENEKVK TEVGKEVAAA RRKQHLSSLQ 
YYCALNALQY RKQMAMMEPM IGFAHGQINF FKKGAEMFSK RMDSFLSSVA DMVQSIQVEL 
EAEAEKMRVS QQELLSVDES VYTPDSDVAA PQINRNLIQK AGYLNLRNKT GLVTTTWERL 
YFFTQGGNLM CQPRGAVAGG LIQDLDNCSV MAVDCEDRRY CFQITTPNGK SGIILQAESR 
KENEEWICAI NNISRQIYLT DNPEAVAIKL NQTALQAVTP ITSFGKKQES SCPSQNLKNS 
EMENENDKIV PKATASLPEA EELIAPGTPI QFDIVLPATE FLDQNRGSRR TNPFGETEDE 
SFPEAEDSLL QQMFIVRFLG SMAVKTDSTT EVIYEAMRQV LAARAIHNIF RMTESHLMVT 
SQSLRLIDPQ TQVSRANFEL TSVTQFAAHQ ENKRLVGFVI RVPESTGEES LSTYIFESNS 
EGEKICYAIN LGKEIIEVQK DPEALAQLML SIPLTNDGKY VLLNDQPDDD DGNPNEHRGA 
ESEA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: APPL2

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Disruption of the ProSAP2 gene in a t(12;22)(q24.1;q13.3) is associated with the 22q13.3 deletion syndrome. PubMed ID: 11431708

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment. PubMed ID: 15016378

APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex. PubMed ID: 17030088

Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides. PubMed ID: 18034774

Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription. PubMed ID: 19433865

Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment. PubMed ID: 21645192

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle. PubMed ID: 24879834

APPL proteins promote TGFbeta-induced nuclear transport of the TGFbeta type I receptor intracellular domain. PubMed ID: 26583432

Membrane curvature protein exhibits interdomain flexibility and binds a small GTPase. PubMed ID: 23055524