Details for: AVPR1A

Gene ID: 552

Symbol: AVPR1A

Ensembl ID: ENSG00000166148

Description: arginine vasopressin receptor 1A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.6696
    Cell Significance Index: -5.7500
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 2.9068
    Cell Significance Index: 11.1300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.5147
    Cell Significance Index: 13.1000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.1738
    Cell Significance Index: 9.8600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.5986
    Cell Significance Index: 6.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.4957
    Cell Significance Index: 367.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.4051
    Cell Significance Index: 85.3200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3050
    Cell Significance Index: 5.3900
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.1864
    Cell Significance Index: 0.6400
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.1600
    Cell Significance Index: 0.9800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1086
    Cell Significance Index: 1.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0651
    Cell Significance Index: 40.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0380
    Cell Significance Index: 4.4300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0296
    Cell Significance Index: 0.4300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0264
    Cell Significance Index: 0.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0163
    Cell Significance Index: 5.8500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0042
    Cell Significance Index: 0.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0029
    Cell Significance Index: 0.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0003
    Cell Significance Index: 0.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0002
    Cell Significance Index: 0.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0010
    Cell Significance Index: -0.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0020
    Cell Significance Index: -0.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0020
    Cell Significance Index: -0.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0030
    Cell Significance Index: -5.6500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0034
    Cell Significance Index: -0.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0041
    Cell Significance Index: -7.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0056
    Cell Significance Index: -7.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0066
    Cell Significance Index: -4.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0075
    Cell Significance Index: -4.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0075
    Cell Significance Index: -5.6800
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0135
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0145
    Cell Significance Index: -1.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0153
    Cell Significance Index: -1.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0161
    Cell Significance Index: -7.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0184
    Cell Significance Index: -5.2900
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0193
    Cell Significance Index: -0.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0222
    Cell Significance Index: -4.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0235
    Cell Significance Index: -4.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0244
    Cell Significance Index: -2.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0251
    Cell Significance Index: -3.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0270
    Cell Significance Index: -5.3600
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0327
    Cell Significance Index: -0.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0356
    Cell Significance Index: -4.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0386
    Cell Significance Index: -4.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0394
    Cell Significance Index: -5.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0643
    Cell Significance Index: -5.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0678
    Cell Significance Index: -4.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0690
    Cell Significance Index: -5.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0726
    Cell Significance Index: -5.5700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0727
    Cell Significance Index: -3.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0736
    Cell Significance Index: -1.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0802
    Cell Significance Index: -5.3900
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0830
    Cell Significance Index: -1.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0867
    Cell Significance Index: -4.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0930
    Cell Significance Index: -4.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0943
    Cell Significance Index: -5.7800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0957
    Cell Significance Index: -3.9200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0972
    Cell Significance Index: -2.7900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1002
    Cell Significance Index: -1.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1002
    Cell Significance Index: -4.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1009
    Cell Significance Index: -2.5900
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1027
    Cell Significance Index: -0.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1030
    Cell Significance Index: -4.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1062
    Cell Significance Index: -5.9600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1079
    Cell Significance Index: -4.6900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1129
    Cell Significance Index: -3.5700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1139
    Cell Significance Index: -2.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1154
    Cell Significance Index: -6.0600
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1181
    Cell Significance Index: -1.6800
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.1223
    Cell Significance Index: -1.1700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1298
    Cell Significance Index: -1.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1422
    Cell Significance Index: -3.8100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1448
    Cell Significance Index: -2.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1453
    Cell Significance Index: -5.0500
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1507
    Cell Significance Index: -1.7100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1520
    Cell Significance Index: -5.5800
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1526
    Cell Significance Index: -1.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1539
    Cell Significance Index: -3.6900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1573
    Cell Significance Index: -1.7100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1590
    Cell Significance Index: -3.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1604
    Cell Significance Index: -5.2500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1616
    Cell Significance Index: -4.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1619
    Cell Significance Index: -5.6700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1619
    Cell Significance Index: -3.1600
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1730
    Cell Significance Index: -1.7000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1763
    Cell Significance Index: -5.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1805
    Cell Significance Index: -5.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1842
    Cell Significance Index: -6.9800
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.1857
    Cell Significance Index: -2.1500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1870
    Cell Significance Index: -4.0400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1875
    Cell Significance Index: -3.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1910
    Cell Significance Index: -5.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1910
    Cell Significance Index: -5.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1917
    Cell Significance Index: -5.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1966
    Cell Significance Index: -5.3500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.2011
    Cell Significance Index: -1.5500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2041
    Cell Significance Index: -2.4000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2070
    Cell Significance Index: -5.1700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2096
    Cell Significance Index: -5.3400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2144
    Cell Significance Index: -4.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AVPR1A is a member of the G protein-coupled receptor family and is characterized by its high affinity for vasopressin. The receptor is composed of seven transmembrane domains and has a unique structure that allows it to bind to vasopressin with high specificity. AVPR1A is also known for its ability to activate phospholipase C activity, which leads to the production of inositol trisphosphate and diacylglycerol, two secondary messengers that play key roles in cellular signaling. **Pathways and Functions:** AVPR1A is involved in several signaling pathways, including: 1. **Calcium-mediated signaling:** AVPR1A activation leads to the release of calcium ions from intracellular stores, which is essential for various cellular processes, including muscle contraction and neuronal signaling. 2. **G protein-coupled receptor signaling pathway:** AVPR1A activation triggers a G protein-coupled receptor signaling pathway that involves the activation of Gq proteins, which in turn lead to the production of inositol trisphosphate and diacylglycerol. 3. **Vasopressin-like receptor binding:** AVPR1A is also involved in the regulation of vasopressin-like receptor binding, which is essential for the regulation of various physiological processes, including blood pressure and water balance. 4. **Regulation of systemic arterial blood pressure:** AVPR1A activation leads to the regulation of systemic arterial blood pressure by vasopressin, which is essential for maintaining blood pressure homeostasis. **Clinical Significance:** AVPR1A dysregulation has been implicated in several human diseases, including: 1. **Diabetes insipidus:** AVPR1A mutations have been identified as a cause of neurohypophyseal diabetes insipidus, a condition characterized by excessive thirst and polyuria. 2. **Hypertension:** AVPR1A activation has been linked to the regulation of blood pressure, and dysregulation of AVPR1A has been implicated in the development of hypertension. 3. **Social behavior disorders:** AVPR1A has been implicated in the regulation of social behavior, and dysregulation of AVPR1A has been linked to social behavior disorders, including maternal aggression and grooming behavior. 4. **Reproductive disorders:** AVPR1A is also involved in the regulation of reproductive processes, including ovulation and sperm ejaculation, and dysregulation of AVPR1A has been implicated in reproductive disorders, including infertility and erectile dysfunction. In conclusion, the AVPR1A gene plays a crucial role in the regulation of various physiological processes, including blood pressure, water balance, and social behavior. Dysregulation of AVPR1A has been implicated in several human diseases, including diabetes insipidus, hypertension, and social behavior disorders. Further research is needed to fully understand the role of AVPR1A in human health and disease.

Genular Protein ID: 2646177688

Symbol: V1AR_HUMAN

Name: Vasopressin V1a receptor

UniProtKB Accession Codes:

P37288

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 11 DrugCentral 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8106369

Title: Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor.

PubMed ID: 8106369

DOI: 10.1016/s0021-9258(17)41863-1

PubMed ID: 8074728

Title: Cloning, functional expression and tissue distribution of human cDNA for the vascular-type vasopressin receptor.

PubMed ID: 8074728

DOI: 10.1006/bbrc.1994.2150

PubMed ID: 9357056

Title: Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma.

PubMed ID: 9357056

DOI: 10.1016/s0196-9781(97)00072-7

PubMed ID: 9581826

Title: Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide.

PubMed ID: 9581826

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12082568

Title: Transmission disequilibrium testing of arginine vasopressin receptor 1A (AVPR1A) polymorphisms in autism.

PubMed ID: 12082568

DOI: 10.1038/sj.mp.4001125

PubMed ID: 16511036

Title: A C-terminal segment of the V1R vasopressin receptor is unstructured in the crystal structure of its chimera with the maltose-binding protein.

PubMed ID: 16511036

DOI: 10.1107/s1744309105007293

Sequence Information:

  • Length: 418
  • Mass: 46800
  • Checksum: 477D4260EC826561
  • Sequence:
    • MRLSAGPDAG PSGNSSPWWP LATGAGNTSR EAEALGEGNG PPRDVRNEEL AKLEIAVLAV 
TFAVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV AFFQVLPQMC WDITYRFRGP 
DWLCRVVKHL QVFGMFASAY MLVVMTADRY IAVCHPLKTL QQPARRSRLM IAAAWVLSFV 
LSTPQYFVFS MIEVNNVTKA RDCWATFIQP WGSRAYVTWM TGGIFVAPVV ILGTCYGFIC 
YNIWCNVRGK TASRQSKGAE QAGVAFQKGF LLAPCVSSVK SISRAKIRTV KMTFVIVTAY 
IVCWAPFFII QMWSVWDPMS VWTESENPTI TITALLGSLN SCCNPWIYMF FSGHLLQDCV 
QSFPCCQNMK EKFNKEDTDS MSRRQTFYSN NRSPTNSTGM WKDSPKSSKS IKFIPVST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.