Details for: EXD2

Gene ID: 55218

Symbol: EXD2

Ensembl ID: ENSG00000081177

Description: exonuclease 3'-5' domain containing 2

Associated with

Other Information

Genular Protein ID: 524475616

Symbol: EXD2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20603073

Title: A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.

PubMed ID: 20603073

DOI: 10.1016/j.molcel.2010.06.023

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 26807646

Title: EXD2 promotes homologous recombination by facilitating DNA end resection.

PubMed ID: 26807646

DOI: 10.1038/ncb3303

PubMed ID: 29335528

Title: EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation.

PubMed ID: 29335528

DOI: 10.1038/s41556-017-0016-9

PubMed ID: 29599527

Title: The mitochondrial outer-membrane location of the EXD2 exonuclease contradicts its direct role in nuclear DNA repair.

PubMed ID: 29599527

DOI: 10.1038/s41598-018-23690-y

PubMed ID: 31255466

Title: EXD2 protects stressed replication forks and is required for cell viability in the absence of BRCA1/2.

PubMed ID: 31255466

DOI: 10.1016/j.molcel.2019.05.026

PubMed ID: 31127291

Title: The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.

PubMed ID: 31127291

DOI: 10.1093/nar/gkz454

Sequence Information:

  • Length: 621
  • Mass: 70353
  • Checksum: CD66A3E68A40C7FF
  • Sequence:
  • MSRQNLVALT VTTLLGVAVG GFVLWKGIQR RRRSKTSPVT QQPQQKVLGS RELPPPEDDQ 
    LHSSAPRSSW KERILKAKVV TVSQEAEWDQ IEPLLRSELE DFPVLGIDCE WVNLEGKASP 
    LSLLQMASPS GLCVLVRLPK LICGGKTLPR TLLDILADGT ILKVGVGCSE DASKLLQDYG 
    LVVRGCLDLR YLAMRQRNNL LCNGLSLKSL AETVLNFPLD KSLLLRCSNW DAETLTEDQV 
    IYAARDAQIS VALFLHLLGY PFSRNSPGEK NDDHSSWRKV LEKCQGVVDI PFRSKGMSRL 
    GEEVNGEATE SQQKPRNKKS KMDGMVPGNH QGRDPRKHKR KPLGVGYSAR KSPLYDNCFL 
    HAPDGQPLCT CDRRKAQWYL DKGIGELVSE EPFVVKLRFE PAGRPESPGD YYLMVKENLC 
    VVCGKRDSYI RKNVIPHEYR KHFPIEMKDH NSHDVLLLCT SCHAISNYYD NHLKQQLAKE 
    FQAPIGSEEG LRLLEDPERR QVRSGARALL NAESLPTQRK EELLQALREF YNTDVVTEEM 
    LQEAASLETR ISNENYVPHG LKVVQCHSQG GLRSLMQLES RWRQHFLDSM QPKHLPQQWS 
    VDHNHQKLLR KFGEDLPIQL S

Genular Protein ID: 4209672468

Symbol: A8K948_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 496
  • Mass: 56354
  • Checksum: 6B5EBEA2F38601E5
  • Sequence:
  • MASPSGLCVL VRLPKLICGG KTLPRTLLDI LADGTILKVG VGCSEDASKL LQDYGLVVRG 
    CLDLRYLAMR QRNNLLCNGL SLKSLAETVL NFPLDKSLLL RCSNWDAETL TEDQVIYAAR 
    DAQISVALFL HLLGYPFSRN SPGKKNDDHS SWRKVLEKCQ GVVDIPFRSK GMSRLGEEVN 
    GEATESQQKP RNKKSKMDGM VPGNHQGRDP RKHKRKPLGV GYSARKSPLY DNCFLHAPDG 
    QPLCTCDRRK AQWYLDKGIG ELVSEEPFVV KLRFEPAGRP ESPGDYYLMV KENLCVVCGK 
    RDSYIRKNVI PHEYRKHFPI EMKDHNSHDV LLLCTSCHAI SNYYDNHLKQ QLAKEFQAPI 
    GSEEGLRLLE DPERRQVRSG ARALLNAESL PTHRKEELLQ ALREFYNTDV VTEEMLQEAA 
    SLETRISNEN YVPHGLKVVQ CHSQGGLRSL MQLESRWRQH FLDSMQPKHL PQQWSVDHNH 
    QKLLRKFGED LPIQLS

Genular Protein ID: 4232872671

Symbol: Q86TX3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 122
  • Mass: 14006
  • Checksum: 89491D2FC224068D
  • Sequence:
  • MSRQNLVALT VTTLLGVAVG GFVLWKGIQR RRRSKTSPVT QQPQQKVLGS RELPPPEDDQ 
    LHSSAPRSSW KERILKAKVV TVSQEAEWDQ IEPLLRSELE DFPVLGIDCE WERHGTYLQW 
    LF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.