Details for: NAT10

Gene ID: 55226

Symbol: NAT10

Ensembl ID: ENSG00000135372

Description: N-acetyltransferase 10

Associated with

Other Information

Genular Protein ID: 3624029306

Symbol: NAT10_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11214970

Title: Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 11214970

DOI: 10.1093/dnares/7.6.347

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14592445

Title: Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERT.

PubMed ID: 14592445

DOI: 10.1016/j.bbrc.2003.09.235

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 17631499

Title: Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes.

PubMed ID: 17631499

DOI: 10.1074/jbc.m703098200

PubMed ID: 18082603

Title: Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation.

PubMed ID: 18082603

DOI: 10.1016/j.molcel.2007.09.023

PubMed ID: 17180247

Title: DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation.

PubMed ID: 17180247

DOI: 10.1007/s11010-006-9390-5

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19303003

Title: NAT10, a nucleolar protein, localizes to the midbody and regulates cytokinesis and acetylation of microtubules.

PubMed ID: 19303003

DOI: 10.1016/j.yexcr.2009.03.007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25411247

Title: Human NAT10 is an ATP-dependent RNA acetyltransferase responsible for N4-acetylcytidine formation in 18 S ribosomal RNA (rRNA).

PubMed ID: 25411247

DOI: 10.1074/jbc.c114.602698

PubMed ID: 24786082

Title: Chemical inhibition of NAT10 corrects defects of laminopathic cells.

PubMed ID: 24786082

DOI: 10.1126/science.1252651

PubMed ID: 25653167

Title: Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1.

PubMed ID: 25653167

DOI: 10.1093/nar/gkv075

PubMed ID: 26882543

Title: NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2.

PubMed ID: 26882543

DOI: 10.15252/embr.201540505

PubMed ID: 27993683

Title: Autoacetylation of NAT10 is critical for its function in rRNA transcription activation.

PubMed ID: 27993683

DOI: 10.1016/j.bbrc.2016.12.092

PubMed ID: 30449621

Title: Acetylation of cytidine in mRNA promotes translation efficiency.

PubMed ID: 30449621

DOI: 10.1016/j.cell.2018.10.030

PubMed ID: 30165671

Title: Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress.

PubMed ID: 30165671

DOI: 10.1093/nar/gky777

PubMed ID: 31722219

Title: CCDC84 Acetylation Oscillation Regulates Centrosome Duplication by Modulating HsSAS-6 Degradation.

PubMed ID: 31722219

DOI: 10.1016/j.celrep.2019.10.028

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 1025
  • Mass: 115730
  • Checksum: 88734933A46EB0EE
  • Sequence:
  • MHRKKVDNRI RILIENGVAE RQRSLFVVVG DRGKDQVVIL HHMLSKATVK ARPSVLWCYK 
    KELGFSSHRK KRMRQLQKKI KNGTLNIKQD DPFELFIAAT NIRYCYYNET HKILGNTFGM 
    CVLQDFEALT PNLLARTVET VEGGGLVVIL LRTMNSLKQL YTVTMDVHSR YRTEAHQDVV 
    GRFNERFILS LASCKKCLVI DDQLNILPIS SHVATMEALP PQTPDESLGP SDLELRELKE 
    SLQDTQPVGV LVDCCKTLDQ AKAVLKFIEG ISEKTLRSTV ALTAARGRGK SAALGLAIAG 
    AVAFGYSNIF VTSPSPDNLH TLFEFVFKGF DALQYQEHLD YEIIQSLNPE FNKAVIRVNV 
    FREHRQTIQY IHPADAVKLG QAELVVIDEA AAIPLPLVKS LLGPYLVFMA STINGYEGTG 
    RSLSLKLIQQ LRQQSAQSQV STTAENKTTT TARLASARTL YEVSLQESIR YAPGDAVEKW 
    LNDLLCLDCL NITRIVSGCP LPEACELYYV NRDTLFCYHK ASEVFLQRLM ALYVASHYKN 
    SPNDLQMLSD APAHHLFCLL PPVPPTQNAL PEVLAVIQVC LEGEISRQSI LNSLSRGKKA 
    SGDLIPWTVS EQFQDPDFGG LSGGRVVRIA VHPDYQGMGY GSRALQLLQM YYEGRFPCLE 
    EKVLETPQEI HTVSSEAVSL LEEVITPRKD LPPLLLKLNE RPAERLDYLG VSYGLTPRLL 
    KFWKRAGFVP VYLRQTPNDL TGEHSCIMLK TLTDEDEADQ GGWLAAFWKD FRRRFLALLS 
    YQFSTFSPSL ALNIIQNRNM GKPAQPALSR EELEALFLPY DLKRLEMYSR NMVDYHLIMD 
    MIPAISRIYF LNQLGDLALS AAQSALLLGI GLQHKSVDQL EKEIELPSGQ LMGLFNRIIR 
    KVVKLFNEVQ EKAIEEQMVA AKDVVMEPTM KTLSDDLDEA AKEFQEKHKK EVGKLKSMDL 
    SEYIIRGDDE EWNEVLNKAG PNASIISLKS DKKRKLEAKQ EPKQSKKLKN RETKNKKDMK 
    LKRKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.