OGFOD1 | ENSG00000087263 | NCBI 55239

Details for: OGFOD1

Gene ID: 55239

Symbol: OGFOD1

Ensembl ID: ENSG00000087263

Description: 2-oxoglutarate and iron dependent oxygenase domain containing 1

Associated with

Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
(R-HSA-163841)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Cell population proliferation
(GO:0008283)
Cytoplasm
(GO:0005737)
Cytoplasmic stress granule
(GO:0010494)
Cytosol
(GO:0005829)
Iron ion binding
(GO:0005506)
L-ascorbic acid binding
(GO:0031418)
Nucleoplasm
(GO:0005654)
Peptidyl-proline 3-dioxygenase activity
(GO:0031544)
Peptidyl-proline dioxygenase activity
(GO:0031543)
Peptidyl-proline hydroxylation
(GO:0019511)
Protein binding
(GO:0005515)
Protein hydroxylation
(GO:0018126)
Regulation of translational termination
(GO:0006449)
Stress granule assembly
(GO:0034063)

Other Information

Proteins

Prolyl 3-hydroxylase OGFOD1

Genular Protein ID: 588698456

Symbol: OGFD1_HUMAN

Name: Prolyl 3-hydroxylase OGFOD1

UniProtKB Accession Codes:

Q8N543 H3BUQ2 Q9H7U5 Q9H9J9 Q9HA87 Q9HCG0 Q9NVB6

Database IDs:

Citations:

PubMed ID: 10997877

Title: Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10997877

DOI: 10.1093/dnares/7.4.271

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20579638

Title: OGFOD1, a member of the 2-oxoglutarate and iron dependent dioxygenase family, functions in ischemic signaling.

PubMed ID: 20579638

DOI: 10.1016/j.febslet.2010.06.015

PubMed ID: 20154146

Title: OGFOD1, a novel modulator of eukaryotic translation initiation factor 2alpha phosphorylation and the cellular response to stress.

PubMed ID: 20154146

DOI: 10.1128/mcb.01350-09

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22002106

Title: Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization.

PubMed ID: 22002106

DOI: 10.1074/mcp.m111.013680

PubMed ID: 24550462

Title: Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy.

PubMed ID: 24550462

DOI: 10.1073/pnas.1311750111

PubMed ID: 24550447

Title: OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation.

PubMed ID: 24550447

DOI: 10.1073/pnas.1314482111

PubMed ID: 25728928

Title: Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases.

PubMed ID: 25728928

DOI: 10.1016/j.str.2015.01.014

Sequence Information:

Length: 542
Mass: 63246
Checksum: 8834BB200D5D8D85
Sequence:

MNGKRPAEPG PARVGKKGKK EVMAEFSDAV TEETLKKQVA EAWSRRTPFS HEVIVMDMDP 
FLHCVIPNFI QSQDFLEGLQ KELMNLDFHE KYNDLYKFQQ SDDLKKRREP HISTLRKILF 
EDFRSWLSDI SKIDLESTID MSCAKYEFTD ALLCHDDELE GRRIAFILYL VPPWDRSMGG 
TLDLYSIDEH FQPKQIVKSL IPSWNKLVFF EVSPVSFHQV SEVLSEEKSR LSISGWFHGP 
SLTRPPNYFE PPIPRSPHIP QDHEILYDWI NPTYLDMDYQ VQIQEEFEES SEILLKEFLK 
PEKFTKVCEA LEHGHVEWSS RGPPNKRFYE KAEESKLPEI LKECMKLFRS EALFLLLSNF 
TGLKLHFLAP SEEDEMNDKK EAETTDITEE GTSHSPPEPE NNQMAISNNS QQSNEQTDPE 
PEENETKKES SVPMCQGELR HWKTGHYTLI HDHSKAEFAL DLILYCGCEG WEPEYGGFTS 
YIAKGEDEEL LTVNPESNSL ALVYRDRETL KFVKHINHRS LEQKKTFPNR TGFWDFSFIY 
YE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: OGFOD1

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10997877

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

OGFOD1, a member of the 2-oxoglutarate and iron dependent dioxygenase family, functions in ischemic signaling. PubMed ID: 20579638

OGFOD1, a novel modulator of eukaryotic translation initiation factor 2alpha phosphorylation and the cellular response to stress. PubMed ID: 20154146

Initial characterization of the human central proteome. PubMed ID: 21269460

Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization. PubMed ID: 22002106

Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy. PubMed ID: 24550462

OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation. PubMed ID: 24550447

Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases. PubMed ID: 25728928