NEIL3 | ENSG00000109674 | NCBI 55247

Details for: NEIL3

Gene ID: 55247

Symbol: NEIL3

Ensembl ID: ENSG00000109674

Description: nei like DNA glycosylase 3

Associated with

Base excision repair
(R-HSA-73884)
Cleavage of the damaged purine
(R-HSA-110331)
Cleavage of the damaged pyrimidine
(R-HSA-110329)
Defective base excision repair associated with neil3
(R-HSA-9629232)
Depyrimidination
(R-HSA-73928)
Disease
(R-HSA-1643685)
Diseases of base excision repair
(R-HSA-9605308)
Diseases of dna repair
(R-HSA-9675135)
Dna repair
(R-HSA-73894)
Neil3-mediated resolution of icls
(R-HSA-9636003)
Recognition and association of dna glycosylase with site containing an affected purine
(R-HSA-110330)
Recognition and association of dna glycosylase with site containing an affected pyrimidine
(R-HSA-110328)
Base-excision repair
(GO:0006284)
Base-excision repair, ap site formation
(GO:0006285)
Bubble dna binding
(GO:0000405)
Chromosome
(GO:0005694)
Class i dna-(apurinic or apyrimidinic site) endonuclease activity
(GO:0140078)
Damaged dna binding
(GO:0003684)
Depurination
(GO:0045007)
Dna-(apurinic or apyrimidinic site) endonuclease activity
(GO:0003906)
Dna n-glycosylase activity
(GO:0019104)
Double-stranded dna binding
(GO:0003690)
Interstrand cross-link repair
(GO:0036297)
Mcm complex binding
(GO:1904931)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Single-stranded dna binding
(GO:0003697)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Endonuclease 8-like 3

Genular Protein ID: 311262591

Symbol: NEIL3_HUMAN

Name: Endonuclease 8-like 3

UniProtKB Accession Codes:

Q8TAT5 Q2PPJ3 Q8NG51 Q9NV95

Database IDs:

Citations:

PubMed ID: 12200441

Title: A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue.

PubMed ID: 12200441

DOI: 10.1074/jbc.m206884200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12433996

Title: Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA.

PubMed ID: 12433996

DOI: 10.1093/nar/gkf618

PubMed ID: 16428305

Title: Hematopoietic tissue-specific expression of mouse Neil3 for endonuclease VIII-like protein.

PubMed ID: 16428305

DOI: 10.1093/jb/mvi168

PubMed ID: 19426544

Title: Expression patterns of Neil3 during embryonic brain development and neoplasia.

PubMed ID: 19426544

DOI: 10.1186/1471-2202-10-45

PubMed ID: 19170771

Title: Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance in Escherichia coli mutant.

PubMed ID: 19170771

DOI: 10.1111/j.1365-2443.2008.01271.x

PubMed ID: 19121397

Title: Expression and purification of NEIL3, a human DNA glycosylase homolog.

PubMed ID: 19121397

DOI: 10.1016/j.pep.2008.11.014

PubMed ID: 22365498

Title: Release from quiescence stimulates the expression of human NEIL3 under the control of the Ras dependent ERK-MAP kinase pathway.

PubMed ID: 22365498

DOI: 10.1016/j.dnarep.2012.01.007

PubMed ID: 22569481

Title: Expression and purification of active mouse and human NEIL3 proteins.

PubMed ID: 22569481

DOI: 10.1016/j.pep.2012.04.022

PubMed ID: 23755964

Title: Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin.

PubMed ID: 23755964

DOI: 10.1016/j.dnarep.2013.04.026

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

Length: 605
Mass: 67769
Checksum: 528B17873ABC9D89
Sequence:

MVEGPGCTLN GEKIRARVLP GQAVTGVRGS ALRSLQGRAL RLAASTVVVS PQAAALNNDS 
SQNVLSLFNG YVYSGVETLG KELFMYFGPK ALRIHFGMKG FIMINPLEYK YKNGASPVLE 
VQLTKDLICF FDSSVELRNS MESQQRIRMM KELDVCSPEF SFLRAESEVK KQKGRMLGDV 
LMDQNVLPGV GNIIKNEALF DSGLHPAVKV CQLTDEQIHH LMKMIRDFSI LFYRCRKAGL 
ALSKHYKVYK RPNCGQCHCR ITVCRFGDNN RMTYFCPHCQ KENPQHVDIC KLPTRNTIIS 
WTSSRVDHVM DSVARKSEEH WTCVVCTLIN KPSSKACDAC LTSRPIDSVL KSEENSTVFS 
HLMKYPCNTF GKPHTEVKIN RKTAFGTTTL VLTDFSNKSS TLERKTKQNQ ILDEEFQNSP 
PASVCLNDIQ HPSKKTTNDI TQPSSKVNIS PTISSESKLF SPAHKKPKTA QYSSPELKSC 
NPGYSNSELQ INMTDGPRTL NPDSPRCSKH NRLCILRVVG KDGENKGRQF YACPLPREAQ 
CGFFEWADLS FPFCNHGKRS TMKTVLKIGP NNGKNFFVCP LGKEKQCNFF QWAENGPGIK 
IIPGC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NEIL3

Associated with

Other Information

A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue. PubMed ID: 12200441

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA. PubMed ID: 12433996

Hematopoietic tissue-specific expression of mouse Neil3 for endonuclease VIII-like protein. PubMed ID: 16428305

Expression patterns of Neil3 during embryonic brain development and neoplasia. PubMed ID: 19426544

Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance in Escherichia coli mutant. PubMed ID: 19170771

Expression and purification of NEIL3, a human DNA glycosylase homolog. PubMed ID: 19121397

Release from quiescence stimulates the expression of human NEIL3 under the control of the Ras dependent ERK-MAP kinase pathway. PubMed ID: 22365498

Expression and purification of active mouse and human NEIL3 proteins. PubMed ID: 22569481

Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin. PubMed ID: 23755964

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163