Details for: MCOLN3

Gene ID: 55283

Symbol: MCOLN3

Ensembl ID: ENSG00000055732

Description: mucolipin TRP cation channel 3

Associated with

Other Information

Genular Protein ID: 393777922

Symbol: MCLN3_HUMAN

Name: Transient receptor potential channel mucolipin 3

UniProtKB Accession Codes:

Q8TDD5 Q5T4H5 Q5T4H6 Q9NV09

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EMDB 3 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 4 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 18369318

Title: A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint-waddler phenotype.

PubMed ID: 18369318

DOI: 10.1038/emboj.2008.56

PubMed ID: 19497048

Title: The calcium channel mucolipin-3 is a novel regulator of trafficking along the endosomal pathway.

PubMed ID: 19497048

DOI: 10.1111/j.1600-0854.2009.00935.x

PubMed ID: 19522758

Title: The Ca(2+) channel TRPML3 regulates membrane trafficking and autophagy.

PubMed ID: 19522758

DOI: 10.1111/j.1600-0854.2009.00924.x

PubMed ID: 20378547

Title: Properties of the TRPML3 channel pore and its stable expansion by the Varitint-Waddler-causing mutation.

PubMed ID: 20378547

DOI: 10.1074/jbc.m109.078204

PubMed ID: 19885840

Title: Functional multimerization of mucolipin channel proteins.

PubMed ID: 19885840

DOI: 10.1002/jcp.21956

PubMed ID: 21245134

Title: Mucolipin-3 regulates luminal calcium, acidification, and membrane fusion in the endosomal pathway.

PubMed ID: 21245134

DOI: 10.1074/jbc.m110.169185

PubMed ID: 23469151

Title: A novel ion channel formed by interaction of TRPML3 with TRPV5.

PubMed ID: 23469151

DOI: 10.1371/journal.pone.0058174

PubMed ID: 29106414

Title: Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states.

PubMed ID: 29106414

DOI: 10.1038/nsmb.3502

Sequence Information:

  • Length: 553
  • Mass: 64248
  • Checksum: 2E63DA196379F9E3
  • Sequence:
    • MADPEVVVSS CSSHEEENRC NFNQQTSPSE ELLLEDQMRR KLKFFFMNPC EKFWARGRKP 
WKLAIQILKI AMVTIQLVLF GLSNQMVVAF KEENTIAFKH LFLKGYMDRM DDTYAVYTQS 
DVYDQLIFAV NQYLQLYNVS VGNHAYENKG TKQSAMAICQ HFYKRGNIYP GNDTFDIDPE 
IETECFFVEP DEPFHIGTPA ENKLNLTLDF HRLLTVELQF KLKAINLQTV RHQELPDCYD 
FTLTITFDNK AHSGRIKISL DNDISIRECK DWHVSGSIQK NTHYMMIFDA FVILTCLVSL 
ILCIRSVIRG LQLQQEFVNF FLLHYKKEVS VSDQMEFVNG WYIMIIISDI LTIIGSILKM 
EIQAKSLTSY DVCSILLGTS TMLVWLGVIR YLGFFAKYNL LILTLQAALP NVIRFCCCAA 
MIYLGYCFCG WIVLGPYHDK FRSLNMVSEC LFSLINGDDM FATFAKMQQK SYLVWLFSRI 
YLYSFISLFI YMILSLFIAL ITDTYETIKQ YQQDGFPETE LRTFISECKD LPNSGKYRLE 
DDPPVSLFCC CKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.