Details for: FBXW7
Associated with
Other Information
Genular Protein ID: 3875320270
Symbol: FBXW7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10531037
PubMed ID: 11565033
Title: Archipelago regulates cyclin E levels in Drosophila and is mutated in human cancer cell lines.
PubMed ID: 11565033
DOI: 10.1038/35095068
PubMed ID: 11565034
Title: Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line.
PubMed ID: 11565034
DOI: 10.1038/35095076
PubMed ID: 12354302
Title: SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production.
PubMed ID: 12354302
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 11585921
Title: SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation.
PubMed ID: 11585921
PubMed ID: 15103331
Title: Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7.
PubMed ID: 15103331
PubMed ID: 14739463
Title: The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling.
PubMed ID: 14739463
PubMed ID: 15611062
Title: The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4.
PubMed ID: 15611062
PubMed ID: 17873522
Title: Fbw7 and Usp28 regulate myc protein stability in response to DNA damage.
PubMed ID: 17873522
DOI: 10.4161/cc.6.19.4804
PubMed ID: 17558397
Title: The ubiquitin-specific protease USP28 is required for MYC stability.
PubMed ID: 17558397
DOI: 10.1038/ncb1601
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 21147854
Title: Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase.
PubMed ID: 21147854
DOI: 10.1242/jcs.073924
PubMed ID: 22608923
Title: Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase.
PubMed ID: 22608923
PubMed ID: 22748924
Title: Structure of a glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface.
PubMed ID: 22748924
PubMed ID: 23082202
Title: The stomatin-like protein SLP-1 and Cdk2 interact with the F-Box protein Fbw7-gamma.
PubMed ID: 23082202
PubMed ID: 24000165
Title: UBE2QL1 is disrupted by a constitutional translocation associated with renal tumor predisposition and is a novel candidate renal tumor suppressor gene.
PubMed ID: 24000165
DOI: 10.1002/humu.22433
PubMed ID: 24344117
Title: FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7.
PubMed ID: 24344117
PubMed ID: 25897075
Title: Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation.
PubMed ID: 25897075
PubMed ID: 25775507
Title: The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc.
PubMed ID: 25775507
PubMed ID: 34741373
Title: CDK1/FBXW7 facilitates degradation and ubiquitination of MLST8 to inhibit progression of renal cell carcinoma.
PubMed ID: 34741373
DOI: 10.1111/cas.15188
PubMed ID: 27238018
Title: Circadian amplitude regulation via FBXW7-targeted REV-ERBalpha degradation.
PubMed ID: 27238018
PubMed ID: 27458189
Title: Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity.
PubMed ID: 27458189
PubMed ID: 26774286
Title: FBXW7 facilitates nonhomologous end-joining via K63-linked polyubiquitylation of XRCC4.
PubMed ID: 26774286
PubMed ID: 27837025
Title: Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors.
PubMed ID: 27837025
PubMed ID: 28007894
Title: The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.
PubMed ID: 28007894
PubMed ID: 29149593
Title: NOTCH2 Hajdu-Cheney mutations escape SCFFBW7-dependent proteolysis to promote osteoporosis.
PubMed ID: 29149593
PubMed ID: 34102342
Title: The deubiquitinase USP38 promotes cell proliferation through stabilizing c-Myc.
PubMed ID: 34102342
PubMed ID: 35395208
Title: Germline variants in tumor suppressor FBXW7 lead to impaired ubiquitination and a neurodevelopmental syndrome.
PubMed ID: 35395208
PubMed ID: 17434132
Title: Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases.
PubMed ID: 17434132
PubMed ID: 26976582
Title: Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface.
PubMed ID: 26976582
PubMed ID: 28727686
Title: FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system.
PubMed ID: 28727686
DOI: 10.1038/mp.2017.138
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 17224074
Title: Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas.
PubMed ID: 17224074
DOI: 10.1186/bcr1637
Sequence Information:
- Length: 707
- Mass: 79663
- Checksum: E4A357F76DFD8203
- Sequence:
MNQELLSVGS KRRRTGGSLR GNPSSSQVDE EQMNRVVEEE QQQQLRQQEE EHTARNGEVV GVEPRPGGQN DSQQGQLEEN NNRFISVDED SSGNQEEQEE DEEHAGEQDE EDEEEEEMDQ ESDDFDQSDD SSREDEHTHT NSVTNSSSIV DLPVHQLSSP FYTKTTKMKR KLDHGSEVRS FSLGKKPCKV SEYTSTTGLV PCSATPTTFG DLRAANGQGQ QRRRITSVQP PTGLQEWLKM FQSWSGPEKL LALDELIDSC EPTQVKHMMQ VIEPQFQRDF ISLLPKELAL YVLSFLEPKD LLQAAQTCRY WRILAEDNLL WREKCKEEGI DEPLHIKRRK VIKPGFIHSP WKSAYIRQHR IDTNWRRGEL KSPKVLKGHD DHVITCLQFC GNRIVSGSDD NTLKVWSAVT GKCLRTLVGH TGGVWSSQMR DNIIISGSTD RTLKVWNAET GECIHTLYGH TSTVRCMHLH EKRVVSGSRD ATLRVWDIET GQCLHVLMGH VAAVRCVQYD GRRVVSGAYD FMVKVWDPET ETCLHTLQGH TNRVYSLQFD GIHVVSGSLD TSIRVWDVET GNCIHTLTGH QSLTSGMELK DNILVSGNAD STVKIWDIKT GQCLQTLQGP NKHQSAVTCL QFNKNFVITS SDDGTVKLWD LKTGEFIRNL VTLESGGSGG VVWRIRASNT KLVCAVGSRN GTEETKLLVL DFDVDMK
Genular Protein ID: 197855336
Symbol: G0Z2K0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
Sequence Information:
- Length: 70
- Mass: 7872
- Checksum: 811F77199995DE38
- Sequence:
MNQELLSVGS KRRRTGGSLR GNPSSSQVDE EQMNRVVEEE QQQQLRQQEE EHTARNGEVV GVEPRPGGQN
Genular Protein ID: 3423565948
Symbol: S4R3U4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
Sequence Information:
- Length: 176
- Mass: 19983
- Checksum: CB4B505045910D20
- Sequence:
MNQELLSVGS KRRRTGGSLR GNPSSSQVDE EQMNRVVEEE QQQQLRQQEE EHTARNGEVV GVEPRPGGQN DSQQGQLEEN NNRFISVDED SSGNQEEQEE DEEHAGEQDE EDEEEEEMDQ ESDDFDQSDD SSREDEHTHT NSVTNSSSIV DLPVHQLSSP FYTKTTKVSI FNILLT
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.