Gene AVPR1B - ENSG00000198049 | NCBI Gene ID: 553

Details for: AVPR1B

Gene ID: 553

Symbol: AVPR1B

Ensembl ID: ENSG00000198049

Description: arginine vasopressin receptor 1B

Associated with

Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
Defective avp does not bind avpr1a,b and causes neurohypophyseal diabetes insipidus (ndi)
(R-HSA-5619099)
Disease
(R-HSA-1643685)
Disorders of transmembrane transporters
(R-HSA-5619115)
G alpha (q) signalling events
(R-HSA-416476)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Peptide ligand-binding receptors
(R-HSA-375276)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Slc transporter disorders
(R-HSA-5619102)
Vasopressin-like receptors
(R-HSA-388479)
Activation of phospholipase c activity
(GO:0007202)
Cellular response to hormone stimulus
(GO:0032870)
Endosome
(GO:0005768)
Golgi apparatus
(GO:0005794)
G protein-coupled receptor signaling pathway
(GO:0007186)
Peptide binding
(GO:0042277)
Plasma membrane
(GO:0005886)
Positive regulation of arachidonic acid secretion
(GO:0090238)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of inositol phosphate biosynthetic process
(GO:0060732)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of phospholipase a2 activity
(GO:0032430)
Positive regulation of vasoconstriction
(GO:0045907)
Protein kinase c binding
(GO:0005080)
Regulation of cell population proliferation
(GO:0042127)
Regulation of systemic arterial blood pressure by vasopressin
(GO:0001992)
Symbiont entry into host cell
(GO:0046718)
Transport across blood-brain barrier
(GO:0150104)
Vasopressin receptor activity
(GO:0005000)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: erythrocyte (CL0000232)
Fold Change: 6.7
Marker Score: 3714
Cell Name: megakaryocyte (CL0000556)
Fold Change: 4.37
Marker Score: 2479.5
Cell Name: microglial cell (CL0000129)
Fold Change: 3.74
Marker Score: 6816
Cell Name: T cell (CL0000084)
Fold Change: 2.39
Marker Score: 4120
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.28
Marker Score: 2290.5
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 2.21
Marker Score: 925
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2
Marker Score: 1996
Cell Name: plasma cell (CL0000786)
Fold Change: 1.88
Marker Score: 2102
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.65
Marker Score: 3424
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.62
Marker Score: 1176
Cell Name: precursor B cell (CL0000817)
Fold Change: 1.44
Marker Score: 954
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 862
Cell Name: B cell (CL0000236)
Fold Change: 1.23
Marker Score: 1174.5
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.19
Marker Score: 494
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7692
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4798
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.11
Marker Score: 510
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1
Marker Score: 516
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71783
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48018
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.99
Marker Score: 469
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.99
Marker Score: 1224
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30406
Cell Name: pericyte (CL0000669)
Fold Change: 0.98
Marker Score: 571.5
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.95
Marker Score: 381
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5348
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.93
Marker Score: 333
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2740
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5288
Cell Name: mast cell (CL0000097)
Fold Change: 0.86
Marker Score: 499
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1269
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.78
Marker Score: 404
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 712
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.75
Marker Score: 1197
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 469
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.72
Marker Score: 763.5
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.71
Marker Score: 374
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.71
Marker Score: 1342
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.71
Marker Score: 1439.5
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.64
Marker Score: 512
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.63
Marker Score: 9906
Cell Name: fibroblast (CL0000057)
Fold Change: 0.6
Marker Score: 580
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.59
Marker Score: 1396
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.57
Marker Score: 179
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.48
Marker Score: 284
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.43
Marker Score: 383
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.39
Marker Score: 300
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.36
Marker Score: 2181
Cell Name: secretory cell (CL0000151)
Fold Change: 0.32
Marker Score: 591
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.3
Marker Score: 109
Cell Name: stromal cell (CL0000499)
Fold Change: 0.25
Marker Score: 294
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.25
Marker Score: 148
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.25
Marker Score: 188
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.24
Marker Score: 116
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.24
Marker Score: 68
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.23
Marker Score: 77.5
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.22
Marker Score: 70
Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 0.22
Marker Score: 60
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.21
Marker Score: 62
Cell Name: type D enteroendocrine cell (CL0000502)
Fold Change: 0.21
Marker Score: 64.5
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.21
Marker Score: 49
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.19
Marker Score: 128
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.19
Marker Score: 67
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.19
Marker Score: 99
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.18
Marker Score: 63
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.18
Marker Score: 45
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.17
Marker Score: 89.5
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.17
Marker Score: 444
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.16
Marker Score: 64
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.15
Marker Score: 47
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.14
Marker Score: 64
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.14
Marker Score: 62
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.14
Marker Score: 36.5
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.14
Marker Score: 63
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.13
Marker Score: 61
Cell Name: podocyte (CL0000653)
Fold Change: 0.13
Marker Score: 48.5
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.13
Marker Score: 41
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.13
Marker Score: 67.5
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.13
Marker Score: 63
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.13
Marker Score: 128
Cell Name: macrophage (CL0000235)
Fold Change: 0.12
Marker Score: 129
Cell Name: endocardial cell (CL0002350)
Fold Change: 0.11
Marker Score: 63
Cell Name: Unknown (CL0000003)
Fold Change: 0.11
Marker Score: 338
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.11
Marker Score: 42
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.11
Marker Score: 43
Cell Name: neutrophil (CL0000775)
Fold Change: 0.1
Marker Score: 60.5
Cell Name: leukocyte (CL0000738)
Fold Change: 0.1
Marker Score: 55
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.09
Marker Score: 64
Cell Name: memory B cell (CL0000787)
Fold Change: 0.08
Marker Score: 64
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.08
Marker Score: 56
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.08
Marker Score: 37
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.08
Marker Score: 57
Cell Name: progenitor cell (CL0011026)
Fold Change: 0.07
Marker Score: 450
Cell Name: astrocyte (CL0000127)
Fold Change: 0.07
Marker Score: 59.5
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.06
Marker Score: 63
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.06
Marker Score: 63
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.06
Marker Score: 64
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.06
Marker Score: 90
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.06
Marker Score: 35

Hover over a box to see details here...

**Key characteristics:** - It is a member of the vasopressin receptor family of G protein-coupled receptors. - It is a type a/1 rhodopsin-like receptor, which are characterized by the presence of an extracellular cysteine-rich domain. - It is expressed in the central nervous system, where it is involved in blood pressure regulation. **Pathways and functions:** - Activation of AVPR1B by its ligand, vasopressin, leads to the activation of phospholipase C, which is a key enzyme in the regulation of blood pressure. - Vasopressin also activates the Class a/1 (rhodopsin-like receptors) pathway, which is involved in regulating blood volume and blood pressure. - It also regulates systemic arterial blood pressure by controlling the release of vasopressin from the kidneys. **Clinical significance:** Mutations in AVPR1B have been linked to several diseases, including neurohypophyseal diabetes insipidus (ndi). Ndi is a genetic disorder that is caused by mutations in genes that encode proteins involved in the regulation of blood pressure. In ndi, mutations in AVPR1B have been shown to result in a decrease in the production of vasopressin, which can lead to hyponatremia and hypovolemia.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

AVPR V1b

Genular Protein ID: 75267635

Symbol: V1BR_HUMAN

Name: AVPR V1b

UniProtKB Accession Codes:

P47901 B0M0J6 Q5TZ00

Database IDs:

Citations:

PubMed ID: 7929452

Title: Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor.

PubMed ID: 7929452

DOI: 10.1016/s0021-9258(18)47129-3

PubMed ID: 7805841

Title: Cloning and characterization of the human V3 pituitary vasopressin receptor.

PubMed ID: 7805841

DOI: 10.1016/0014-5793(94)01268-7

PubMed ID: 9357056

Title: Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma.

PubMed ID: 9357056

DOI: 10.1016/s0196-9781(97)00072-7

PubMed ID: 9581826

Title: Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide.

PubMed ID: 9581826

PubMed ID: 10607899

Title: Nucleotide sequence and structural organization of the human vasopressin pituitary receptor (V3) gene.

PubMed ID: 10607899

DOI: 10.1016/s0378-1119(99)00468-0

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 33713620

Title: Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system.

PubMed ID: 33713620

DOI: 10.1016/j.cell.2021.02.053

PubMed ID: 17909131

Title: Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders.

PubMed ID: 17909131

DOI: 10.1001/archpsyc.64.10.1189

Sequence Information:

Length: 424
Mass: 46971
Checksum: 35190281D3EDB6A7
Sequence:

MDSGPLWDAN PTPRGTLSAP NATTPWLGRD EELAKVEIGV LATVLVLATG GNLAVLLTLG 
QLGRKRSRMH LFVLHLALTD LAVALFQVLP QLLWDITYRF QGPDLLCRAV KYLQVLSMFA 
STYMLLAMTL DRYLAVCHPL RSLQQPGQST YLLIAAPWLL AAIFSLPQVF IFSLREVIQG 
SGVLDCWADF GFPWGPRAYL TWTTLAIFVL PVTMLTACYS LICHEICKNL KVKTQAWRVG 
GGGWRTWDRP SPSTLAATTR GLPSRVSSIN TISRAKIRTV KMTFVIVLAY IACWAPFFSV 
QMWSVWDKNA PDEDSTNVAF TISMLLGNLN SCCNPWIYMG FNSHLLPRPL RHLACCGGPQ 
PRMRRRLSDG SLSSRHTTLL TRSSCPATLS LSLSLTLSGR PRPEESPRDL ELADGEGTAE 
TIIF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: AVPR1B

Associated with

Cells (max top 100)

Other Information

Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor. PubMed ID: 7929452

Cloning and characterization of the human V3 pituitary vasopressin receptor. PubMed ID: 7805841

Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma. PubMed ID: 9357056

Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide. PubMed ID: 9581826

Nucleotide sequence and structural organization of the human vasopressin pituitary receptor (V3) gene. PubMed ID: 10607899

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system. PubMed ID: 33713620

Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders. PubMed ID: 17909131