Details for: AVPR1B

Gene ID: 553

Symbol: AVPR1B

Ensembl ID: ENSG00000198049

Description: arginine vasopressin receptor 1B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 4.8303
    Cell Significance Index: 45.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.9238
    Cell Significance Index: 240.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.1909
    Cell Significance Index: 69.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.7713
    Cell Significance Index: 527.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 2.0088
    Cell Significance Index: 41.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.9932
    Cell Significance Index: 63.8400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.9850
    Cell Significance Index: 25.6900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.9106
    Cell Significance Index: 37.3600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7466
    Cell Significance Index: 15.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6265
    Cell Significance Index: 61.9700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5863
    Cell Significance Index: 8.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5761
    Cell Significance Index: 520.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5439
    Cell Significance Index: 32.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4902
    Cell Significance Index: 53.3200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.3905
    Cell Significance Index: 5.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3516
    Cell Significance Index: 57.1800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.3255
    Cell Significance Index: 8.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2753
    Cell Significance Index: 19.0400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1494
    Cell Significance Index: 2.1400
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.1383
    Cell Significance Index: 1.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0456
    Cell Significance Index: 2.3700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0405
    Cell Significance Index: 0.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0336
    Cell Significance Index: 0.8400
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.0241
    Cell Significance Index: 0.2900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0222
    Cell Significance Index: 0.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0222
    Cell Significance Index: 0.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0146
    Cell Significance Index: 0.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0030
    Cell Significance Index: 1.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0017
    Cell Significance Index: 0.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0000
    Cell Significance Index: -0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0004
    Cell Significance Index: -0.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0005
    Cell Significance Index: -0.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -1.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0009
    Cell Significance Index: -0.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0013
    Cell Significance Index: -0.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0014
    Cell Significance Index: -0.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0015
    Cell Significance Index: -0.6900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0020
    Cell Significance Index: -1.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0021
    Cell Significance Index: -1.3400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0021
    Cell Significance Index: -0.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0029
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0031
    Cell Significance Index: -0.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0032
    Cell Significance Index: -0.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0032
    Cell Significance Index: -0.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0040
    Cell Significance Index: -0.7900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0041
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0043
    Cell Significance Index: -0.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0060
    Cell Significance Index: -0.8300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0063
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0065
    Cell Significance Index: -0.7400
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.0077
    Cell Significance Index: -0.0800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0092
    Cell Significance Index: -0.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0094
    Cell Significance Index: -1.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0098
    Cell Significance Index: -1.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0098
    Cell Significance Index: -1.0200
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0110
    Cell Significance Index: -0.1200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0113
    Cell Significance Index: -0.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0114
    Cell Significance Index: -0.7000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0117
    Cell Significance Index: -0.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0135
    Cell Significance Index: -1.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0139
    Cell Significance Index: -0.3700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0146
    Cell Significance Index: -0.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0164
    Cell Significance Index: -0.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0195
    Cell Significance Index: -1.3100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0206
    Cell Significance Index: -0.2500
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0211
    Cell Significance Index: -0.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0229
    Cell Significance Index: -0.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0248
    Cell Significance Index: -0.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0248
    Cell Significance Index: -1.3900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0258
    Cell Significance Index: -0.7400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0267
    Cell Significance Index: -0.3600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0284
    Cell Significance Index: -0.3000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0286
    Cell Significance Index: -0.6600
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0300
    Cell Significance Index: -0.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0305
    Cell Significance Index: -1.0000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0334
    Cell Significance Index: -0.8000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0361
    Cell Significance Index: -1.1500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0373
    Cell Significance Index: -0.5500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0407
    Cell Significance Index: -1.0400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0412
    Cell Significance Index: -0.4900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0414
    Cell Significance Index: -0.6400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0417
    Cell Significance Index: -1.1900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0440
    Cell Significance Index: -0.6300
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.0447
    Cell Significance Index: -0.5000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0450
    Cell Significance Index: -0.7700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0451
    Cell Significance Index: -0.5900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0456
    Cell Significance Index: -0.5900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0456
    Cell Significance Index: -0.5700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0466
    Cell Significance Index: -0.3800
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0468
    Cell Significance Index: -0.7000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0471
    Cell Significance Index: -0.6700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0481
    Cell Significance Index: -1.2000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0483
    Cell Significance Index: -0.9500
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0486
    Cell Significance Index: -0.4400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0493
    Cell Significance Index: -0.9900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0493
    Cell Significance Index: -0.5800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0496
    Cell Significance Index: -0.9900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0497
    Cell Significance Index: -0.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **G-protein Coupled Receptor (GPCR) Structure:** AVPR1B belongs to the class A/1 rhodopsin-like receptors, characterized by a seven-transmembrane domain structure. 2. **Ligand Binding:** AVPR1B specifically binds to arginine vasopressin (AVP), which is essential for its physiological functions. 3. **Signaling Pathways:** The receptor's activation triggers a cascade of downstream signaling pathways, including the activation of phospholipase C, phospholipase A2, and protein kinase C. 4. **Expression and Localization:** AVPR1B is expressed in multiple cell types, including those in the kidney, brain, and gastrointestinal tract. **Pathways and Functions:** 1. **Vasopressin Signaling:** AVPR1B mediates the effects of AVP, which is essential for regulating water balance, blood pressure, and electrolyte homeostasis. 2. **Cellular Response to Hormone Stimulus:** The receptor's activation leads to a cellular response to hormone stimulation, influencing various physiological processes. 3. **Regulation of Cell Population Proliferation:** AVPR1B plays a role in regulating cell population proliferation, particularly in megakaryocytes and T cells. 4. **Regulation of Systemic Arterial Blood Pressure:** The receptor's activation contributes to the regulation of systemic arterial blood pressure by vasopressin. 5. **Signal Transduction:** AVPR1B is involved in various signal transduction pathways, including G-protein coupled receptor signaling pathways and Gpcr downstream signaling. **Clinical Significance:** 1. **Neurohypophyseal Diabetes Insipidus (NDI):** Defects in AVPR1B can lead to NDI, a condition characterized by excessive urine production and dehydration. 2. **Hypertension:** AVPR1B may play a role in regulating blood pressure, and alterations in its function may contribute to hypertension. 3. **Gastrointestinal Disorders:** The receptor's expression in colon goblet cells suggests its potential involvement in gastrointestinal disorders, such as diarrhea or constipation. 4. **Immunological Disorders:** AVPR1B's expression in T cells and microglial cells highlights its potential role in immunological disorders, such as autoimmune diseases or neuroinflammation. In conclusion, the AVPR1B gene plays a critical role in regulating various physiological processes, including water balance, blood pressure, and cell proliferation. Its dysregulation can lead to various clinical disorders, highlighting the importance of further research into the mechanisms of AVPR1B and its potential therapeutic applications.

Genular Protein ID: 75267635

Symbol: V1BR_HUMAN

Name: AVPR V1b

UniProtKB Accession Codes:

P47901 B0M0J6 Q5TZ00

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EMBL 8 Ensembl 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7929452

Title: Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor.

PubMed ID: 7929452

DOI: 10.1016/s0021-9258(18)47129-3

PubMed ID: 7805841

Title: Cloning and characterization of the human V3 pituitary vasopressin receptor.

PubMed ID: 7805841

DOI: 10.1016/0014-5793(94)01268-7

PubMed ID: 9357056

Title: Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma.

PubMed ID: 9357056

DOI: 10.1016/s0196-9781(97)00072-7

PubMed ID: 9581826

Title: Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide.

PubMed ID: 9581826

PubMed ID: 10607899

Title: Nucleotide sequence and structural organization of the human vasopressin pituitary receptor (V3) gene.

PubMed ID: 10607899

DOI: 10.1016/s0378-1119(99)00468-0

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 33713620

Title: Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system.

PubMed ID: 33713620

DOI: 10.1016/j.cell.2021.02.053

PubMed ID: 17909131

Title: Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders.

PubMed ID: 17909131

DOI: 10.1001/archpsyc.64.10.1189

Sequence Information:

  • Length: 424
  • Mass: 46971
  • Checksum: 35190281D3EDB6A7
  • Sequence:
    • MDSGPLWDAN PTPRGTLSAP NATTPWLGRD EELAKVEIGV LATVLVLATG GNLAVLLTLG 
QLGRKRSRMH LFVLHLALTD LAVALFQVLP QLLWDITYRF QGPDLLCRAV KYLQVLSMFA 
STYMLLAMTL DRYLAVCHPL RSLQQPGQST YLLIAAPWLL AAIFSLPQVF IFSLREVIQG 
SGVLDCWADF GFPWGPRAYL TWTTLAIFVL PVTMLTACYS LICHEICKNL KVKTQAWRVG 
GGGWRTWDRP SPSTLAATTR GLPSRVSSIN TISRAKIRTV KMTFVIVLAY IACWAPFFSV 
QMWSVWDKNA PDEDSTNVAF TISMLLGNLN SCCNPWIYMG FNSHLLPRPL RHLACCGGPQ 
PRMRRRLSDG SLSSRHTTLL TRSSCPATLS LSLSLTLSGR PRPEESPRDL ELADGEGTAE 
TIIF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.