PI4K2B | ENSG00000038210 | NCBI 55300

Details for: PI4K2B

Gene ID: 55300

Symbol: PI4K2B

Ensembl ID: ENSG00000038210

Description: phosphatidylinositol 4-kinase type 2 beta

Associated with

Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Phospholipid metabolism
(R-HSA-1483257)
Pi metabolism
(R-HSA-1483255)
Synthesis of pips at the early endosome membrane
(R-HSA-1660516)
Synthesis of pips at the er membrane
(R-HSA-1483248)
Synthesis of pips at the golgi membrane
(R-HSA-1660514)
Synthesis of pips at the plasma membrane
(R-HSA-1660499)
1-phosphatidylinositol 4-kinase activity
(GO:0004430)
Atp binding
(GO:0005524)
Cytosol
(GO:0005829)
Early endosome membrane
(GO:0031901)
Endoplasmic reticulum membrane
(GO:0005789)
Endosome
(GO:0005768)
Endosome organization
(GO:0007032)
Golgi membrane
(GO:0000139)
Golgi organization
(GO:0007030)
Membrane
(GO:0016020)
Phosphatidylinositol biosynthetic process
(GO:0006661)
Phosphatidylinositol phosphate biosynthetic process
(GO:0046854)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Trans-golgi network
(GO:0005802)

Other Information

Proteins

Phosphatidylinositol 4-kinase type 2-beta
G5E9Z4_HUMAN

Genular Protein ID: 400964706

Symbol: P4K2B_HUMAN

Name: Phosphatidylinositol 4-kinase type 2-beta

UniProtKB Accession Codes:

Q8TCG2 Q9NUW2

Database IDs:

Citations:

PubMed ID: 11923287

Title: Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments.

PubMed ID: 11923287

DOI: 10.1074/jbc.m111807200

PubMed ID: 12324459

Title: Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP.

PubMed ID: 12324459

DOI: 10.1074/jbc.m206860200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26143926

Title: The high-resolution crystal structure of phosphatidylinositol 4-kinase IIbeta and the crystal structure of phosphatidylinositol 4-kinase IIalpha containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design.

PubMed ID: 26143926

DOI: 10.1107/s1399004715009505

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

Sequence Information:

Length: 481
Mass: 54744
Checksum: B4E16257E0AEC026
Sequence:

MEDPSEPDRL ASADGGSPEE EEDGEREPLL PRIAWAHPRR GAPGSAVRLL DAAGEEGEAG 
DEELPLPPGD VGVSRSSSAE LDRSRPAVSV TIGTSEMNAF LDDPEFADIM LRAEQAIEVG 
IFPERISQGS SGSYFVKDPK RKIIGVFKPK SEEPYGQLNP KWTKYVHKVC CPCCFGRGCL 
IPNQGYLSEA GAYLVDNKLH LSIVPKTKVV WLVSETFNYN AIDRAKSRGK KYALEKVPKV 
GRKFHRIGLP PKIGSFQLFV EGYKEAEYWL RKFEADPLPE NIRKQFQSQF ERLVILDYII 
RNTDRGNDNW LVRYEKQKCE KEIDHKESKW IDDEEFLIKI AAIDNGLAFP FKHPDEWRAY 
PFHWAWLPQA KVPFSEEIRN LILPYISDMN FVQDLCEDLY ELFKTDKGFD KATFESQMSV 
MRGQILNLTQ ALRDGKSPFQ LVQIPCVIVE RSQGGSQGRI VHLSNSFTQT VNCRKPFFSS 
W

Genular Protein ID: 1488221157

Symbol: G5E9Z4_HUMAN

Name: N/A

UniProtKB Accession Codes:

G5E9Z4

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

Length: 385
Mass: 44761
Checksum: 96A60797ABD0A504
Sequence:

MNAFLDDPEF ADIMLRAEQA IEVGIFPERI SQGSSGSYFV KDPKRKIIGV FKPKSEEPYG 
QLNPKWTKYV HKVCCPCCFG RGCLIPNQGY LSEAGAYLVD NKLHLSIVPK TKVVWLVSET 
FNYNAIDRAK SRGKKYALEK VPKVGRKFHR IGLPPKIGSF QLFVEGYKEA EYWLRKFEAD 
PLPENIRKQF QSQFERLVIL DYIIRNTDRG NDNWLVRYEK QKCEKEIDHK ESKWIDDEEF 
LIKIAAIDNG LAFPFKHPDE WRAYPFHWAW LPQAKVPFSE EIRNLILPYI SDMNFVQDLC 
EDLYELFKTD KGFDKATFES QMSVMRGQIL NLTQALRDGK SPFQLVQIPC VIVERSQGGS 
QGRIVHLSNS FTQTVNCRKP FFSSW

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PI4K2B

Associated with

Other Information

Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments. PubMed ID: 11923287

Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP. PubMed ID: 12324459

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

The high-resolution crystal structure of phosphatidylinositol 4-kinase IIbeta and the crystal structure of phosphatidylinositol 4-kinase IIalpha containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design. PubMed ID: 26143926

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

The sequence of the human genome. PubMed ID: 11181995

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621