Details for: LAPTM4B

Gene ID: 55353

Symbol: LAPTM4B

Ensembl ID: ENSG00000104341

Description: lysosomal protein transmembrane 4 beta

Associated with

Other Information

Genular Protein ID: 2268788809

Symbol: LAP4B_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86VI4 Q3ZCV5 Q7L909 Q86VH8 Q9H060

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 19 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SAM 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12902989

Title: Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma.

PubMed ID: 12902989

DOI: 10.1038/sj.onc.1206832

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 21224396

Title: LAPTMs regulate lysosomal function and interact with mucolipin 1: new clues for understanding mucolipidosis type IV.

PubMed ID: 21224396

DOI: 10.1242/jcs.076240

PubMed ID: 22096579

Title: A role for the ubiquitin ligase Nedd4 in membrane sorting of LAPTM4 proteins.

PubMed ID: 22096579

DOI: 10.1371/journal.pone.0027478

PubMed ID: 25588945

Title: LAPTM4B is a PtdIns(4,5)P2 effector that regulates EGFR signaling, lysosomal sorting, and degradation.

PubMed ID: 25588945

DOI: 10.15252/embj.201489425

PubMed ID: 26126825

Title: Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor beta1 (TGF-beta1) Production in Human Regulatory T Cells.

PubMed ID: 26126825

DOI: 10.1074/jbc.m115.655340

PubMed ID: 26280656

Title: LAPTM4B facilitates late endosomal ceramide export to control cell death pathways.

PubMed ID: 26280656

DOI: 10.1038/nchembio.1889

PubMed ID: 25998567

Title: LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation.

PubMed ID: 25998567

DOI: 10.1038/ncomms8250

PubMed ID: 28479384

Title: Beclin1 antagonizes LAPTM4B-mediated EGFR overactivation in gastric cancer cells.

PubMed ID: 28479384

DOI: 10.1016/j.gene.2017.05.006

Sequence Information:

  • Length: 317
  • Mass: 35123
  • Checksum: 4E93093E066BE948
  • Sequence:
    • MTSRTRVTWP SPPRPLPVPA AAAVAFGAKG TDPAEARSSR GIEEAGPRAH GRAGREPERR 
RSRQQRRGGL QARRSTLLKT CARARATAPG AMKMVAPWTR FYSNSCCLCC HVRTGTILLG 
VWYLIINAVV LLILLSALAD PDQYNFSSSE LGGDFEFMDD ANMCIAIAIS LLMILICAMA 
TYGAYKQRAA WIIPFFCYQI FDFALNMLVA ITVLIYPNSI QEYIRQLPPN FPYRDDVMSV 
NPTCLVLIIL LFISIILTFK GYLISCVWNC YRYINGRNSS DVLVYVTSND TTVLLPPYDD 
ATVNGAAKEP PPPYVSA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.