Details for: LGR4

Gene ID: 55366

Symbol: LGR4

Ensembl ID: ENSG00000205213

Description: leucine rich repeat containing G protein-coupled receptor 4

Associated with

  • Regulation of fzd by ubiquitination
    (R-HSA-4641263)
  • Signaling by wnt
    (R-HSA-195721)
  • Signal transduction
    (R-HSA-162582)
  • Tcf dependent signaling in response to wnt
    (R-HSA-201681)
  • Activation of adenylate cyclase activity
    (GO:0007190)
  • Adenylate cyclase-activating g protein-coupled receptor signaling pathway
    (GO:0007189)
  • Bone mineralization
    (GO:0030282)
  • Bone remodeling
    (GO:0046849)
  • Cell differentiation involved in metanephros development
    (GO:0072202)
  • Circadian regulation of gene expression
    (GO:0032922)
  • Digestive tract development
    (GO:0048565)
  • Epithelial cell proliferation involved in renal tubule morphogenesis
    (GO:2001013)
  • G protein-coupled peptide receptor activity
    (GO:0008528)
  • G protein-coupled receptor activity
    (GO:0004930)
  • Hair follicle development
    (GO:0001942)
  • Innate immune response
    (GO:0045087)
  • Intestinal stem cell homeostasis
    (GO:0036335)
  • Male genitalia development
    (GO:0030539)
  • Metanephric glomerulus development
    (GO:0072224)
  • Metanephric nephron tubule morphogenesis
    (GO:0072282)
  • Negative regulation of cold-induced thermogenesis
    (GO:0120163)
  • Negative regulation of cytokine production
    (GO:0001818)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of toll-like receptor signaling pathway
    (GO:0034122)
  • Osteoblast differentiation
    (GO:0001649)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of branching involved in ureteric bud morphogenesis
    (GO:0090190)
  • Positive regulation of canonical wnt signaling pathway
    (GO:0090263)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Protein-hormone receptor activity
    (GO:0016500)
  • Protein binding
    (GO:0005515)
  • Spermatogenesis
    (GO:0007283)
  • Transmembrane signaling receptor activity
    (GO:0004888)

Other Information

Genular Protein ID: 1625257171

Symbol: LGR4_HUMAN

Name: Leucine-rich repeat-containing G-protein coupled receptor 4

UniProtKB Accession Codes:

Q9BXB1 A6NCH3 G5E9B3 Q8N537 Q9NYD1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 28 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 6 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11401528

Title: Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor.

PubMed ID: 11401528

DOI: 10.1006/bbrc.2001.4625

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21909076

Title: LGR4 and LGR5 are R-spondin receptors mediating Wnt/beta-catenin and Wnt/PCP signalling.

PubMed ID: 21909076

DOI: 10.1038/embor.2011.175

PubMed ID: 21727895

Title: Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.

PubMed ID: 21727895

DOI: 10.1038/nature10337

PubMed ID: 21693646

Title: R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.

PubMed ID: 21693646

DOI: 10.1073/pnas.1106083108

PubMed ID: 22815884

Title: R-Spondin potentiates Wnt/beta-catenin signaling through orphan receptors LGR4 and LGR5.

PubMed ID: 22815884

DOI: 10.1371/journal.pone.0040976

PubMed ID: 23444378

Title: Multi-functional norrin is a ligand for the LGR4 receptor.

PubMed ID: 23444378

DOI: 10.1242/jcs.123471

PubMed ID: 23644456

Title: Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits.

PubMed ID: 23644456

DOI: 10.1038/nature12124

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 23756652

Title: Structural basis for R-spondin recognition by LGR4/5/6 receptors.

PubMed ID: 23756652

DOI: 10.1101/gad.219360.113

PubMed ID: 32493844

Title: LGR4 deficiency results in delayed puberty through impaired Wnt/beta-catenin signaling.

PubMed ID: 32493844

DOI: 10.1172/jci.insight.133434

Sequence Information:

  • Length: 951
  • Mass: 104475
  • Checksum: 42D48AE5F0BEB6B1
  • Sequence:
    • MPGPLGLLCF LALGLLGSAG PSGAAPPLCA APCSCDGDRR VDCSGKGLTA VPEGLSAFTQ 
ALDISMNNIT QLPEDAFKNF PFLEELQLAG NDLSFIHPKA LSGLKELKVL TLQNNQLKTV 
PSEAIRGLSA LQSLRLDANH ITSVPEDSFE GLVQLRHLWL DDNSLTEVPV HPLSNLPTLQ 
ALTLALNKIS SIPDFAFTNL SSLVVLHLHN NKIRSLSQHC FDGLDNLETL DLNYNNLGEF 
PQAIKALPSL KELGFHSNSI SVIPDGAFDG NPLLRTIHLY DNPLSFVGNS AFHNLSDLHS 
LVIRGASMVQ QFPNLTGTVH LESLTLTGTK ISSIPNNLCQ EQKMLRTLDL SYNNIRDLPS 
FNGCHALEEI SLQRNQIYQI KEGTFQGLIS LRILDLSRNL IHEIHSRAFA TLGPITNLDV 
SFNELTSFPT EGLNGLNQLK LVGNFKLKEA LAAKDFVNLR SLSVPYAYQC CAFWGCDSYA 
NLNTEDNSLQ DHSVAQEKGT ADAANVTSTL ENEEHSQIII HCTPSTGAFK PCEYLLGSWM 
IRLTVWFIFL VALFFNLLVI LTTFASCTSL PSSKLFIGLI SVSNLFMGIY TGILTFLDAV 
SWGRFAEFGI WWETGSGCKV AGFLAVFSSE SAIFLLMLAT VERSLSAKDI MKNGKSNHLK 
QFRVAALLAF LGATVAGCFP LFHRGEYSAS PLCLPFPTGE TPSLGFTVTL VLLNSLAFLL 
MAVIYTKLYC NLEKEDLSEN SQSSMIKHVA WLIFTNCIFF CPVAFFSFAP LITAISISPE 
IMKSVTLIFF PLPACLNPVL YVFFNPKFKE DWKLLKRRVT KKSGSVSVSI SSQGGCLEQD 
FYYDCGMYSH LQGNLTVCDC CESFLLTKPV SCKHLIKSHS CPALAVASCQ RPEGYWSDCG 
TQSAHSDYAD EEDSFVSDSS DQVQACGRAC FYQSRGFPLV RYAYNLPRVK D

Genular Protein ID: 1930190627

Symbol: Q59ER8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59ER8

Database IDs:

ARBA 14 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 2 SAM 1 SMART 4 SUPFAM 2

Sequence Information:

  • Length: 1032
  • Mass: 112564
  • Checksum: CE35C9546AF1C8FD
  • Sequence:
    • AAGGAGLPLR VHGAAGRAKL RSAASLRRCG GLLKGPSPRG PPRKRPPLQP AGRLPGGGGG 
HRRAAERAAP RERPAREAAA AMPGPLGLLC FLALGLLGSA GPSGAAPPLC AAPCSCDGDR 
RVDCSGKGLT AVPEGLSAFT QALDISMNNI TQLPEDAFKN FPFLEELQLA GNDLSFIHPK 
ALSGLKELKV LTLQNNQLKT VPSEAIRGLS ALQSLRLDAN HITSVPEDSF EGLVQLRHLW 
LDDNSLTEVP VHPLSNLPTL QALTLALNKI SSIPDFAFTN LSSLVVLHLH NNKIRSLSQH 
CFDGLDNLET LDLNYNNLGE FPQAIKALPS LKELGFHSNS ISVIPDGAFD GNPLLRTIHL 
YDNPLSFVGN SAFHNLSDLH SLVIRGASMV QQFPNLTGTV HLESLTLTGT KISSIPNNLC 
QEQKMLRTLD LSYNNIRDLP SFNGCHALEE ISLQRNQIYQ IKEGTFQGLI SLRILDLSRN 
LIHEIHSRAF ATLGPITNLD VSFNELTSFP TEGLNGLNQL KLVGNFKLKE ALAAKDFVNL 
RSLSVPYAYQ CCAFWGCDSY ANLNTEDNSL QDHSVAQEKG TADAANVTST LENEEHSQII 
IHCTPSTGAF KPCEYLLGSW MIRLTVWFIF LVALFFNLLV ILTTFASCTS LPSSKLFIGL 
ISVSNLFMGI YTGILTFLDA VSWGRFAEFG IWWETGSGCK VAGFLAVFSS ESAIFLLMLA 
TVERSLSAKD IMKNGKSNHL KQFRVAALLA FLGATVAGCF PLFHRGEYSA SPLCLPFPTG 
ETPSLGFTVT LVLLNSLAFL LMAVIYTKLY CNLEKEDLSE NSQSSMIKHV AWLIFTNCIF 
FCPVAFFSFA PLITAISISP EIMKSVTLIF FPLPACLNPV LYVFFNPKFK EDWKLLKRRV 
TKKSGSVSVS ISSQGGCLEQ DFYYDCGMYS HLQGNLTVCD CCESFLLTKP VSCKHLIKSH 
SCPALAVASC QRPEGYWSDC GTQSAHSDYA DEEDSFVSDS SDQVQACGRA CFYQSRGFPL 
VRYAYNLPRV KD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.