MCM10 | ENSG00000065328 | NCBI 55388

Details for: MCM10

Gene ID: 55388

Symbol: MCM10

Ensembl ID: ENSG00000065328

Description: minichromosome maintenance 10 replication initiation factor

Associated with

Activation of atr in response to replication stress
(R-HSA-176187)
Activation of the pre-replicative complex
(R-HSA-68962)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
G1/s transition
(R-HSA-69206)
G2/m checkpoints
(R-HSA-69481)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Cell population proliferation
(GO:0008283)
Dna damage response
(GO:0006974)
Dna replication initiation
(GO:0006270)
Dna replication origin binding
(GO:0003688)
Enzyme binding
(GO:0019899)
Identical protein binding
(GO:0042802)
Metal ion binding
(GO:0046872)
Nuclear replication fork
(GO:0043596)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Single-stranded dna binding
(GO:0003697)

Other Information

Proteins

Protein MCM10 homolog

Genular Protein ID: 1682938417

Symbol: MCM10_HUMAN

Name: Protein MCM10 homolog

UniProtKB Accession Codes:

Q7L590 A8K9I6 B7ZKZ8 Q3MIR3 Q7LD55 Q96GX4 Q96NB6 Q9H0D7 Q9H3P9 Q9P177

Database IDs:

Citations:

PubMed ID: 11095689

Title: The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase.

PubMed ID: 11095689

DOI: 10.1093/nar/28.23.4769

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11602595

Title: Cell cycle-dependent proteolysis and phosphorylation of human Mcm10.

PubMed ID: 11602595

DOI: 10.1074/jbc.m107190200

PubMed ID: 15136575

Title: Localization of human Mcm10 is spatially and temporally regulated during the S phase.

PubMed ID: 15136575

DOI: 10.1074/jbc.m314017200

PubMed ID: 17761813

Title: Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication.

PubMed ID: 17761813

DOI: 10.1101/gad.1585607

PubMed ID: 17699597

Title: Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication.

PubMed ID: 17699597

DOI: 10.1091/mbc.e06-12-1148

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19696745

Title: MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication.

PubMed ID: 19696745

DOI: 10.1038/emboj.2009.235

PubMed ID: 19608746

Title: Physical interactions between Mcm10, DNA, and DNA polymerase alpha.

PubMed ID: 19608746

DOI: 10.1074/jbc.m109.020438

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 24726359

Title: The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability.

PubMed ID: 24726359

DOI: 10.1016/j.celrep.2014.03.030

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 32865517

Title: Human NK cell deficiency as a result of biallelic mutations in MCM10.

PubMed ID: 32865517

DOI: 10.1172/jci134966

Sequence Information:

Length: 875
Mass: 98183
Checksum: DD87191FFF3729D4
Sequence:

MDEEEDNLSL LTALLEENES ALDCNSEENN FLTRENGEPD AFDELFDADG DGESYTEEAD 
DGETGETRDE KENLATLFGD MEDLTDEEEV PASQSTENRV LPAPAPRREK TNEELQEELR 
NLQEQMKALQ EQLKVTTIKQ TASPARLQKS PVEKSPRPPL KERRVQRIQE STCFSAELDV 
PALPRTKRVA RTPKASPPDP KSSSSRMTSA PSQPLQTISR NKPSGITRGQ IVGTPGSSGE 
TTQPICVEAF SGLRLRRPRV SSTEMNKKMT GRKLIRLSQI KEKMAREKLE EIDWVTFGVI 
LKKVTPQSVN SGKTFSIWKL NDLRDLTQCV SLFLFGEVHK ALWKTEQGTV VGILNANPMK 
PKDGSEEVCL SIDHPQKVLI MGEALDLGTC KAKKKNGEPC TQTVNLRDCE YCQYHVQAQY 
KKLSAKRADL QSTFSGGRIP KKFARRGTSL KERLCQDGFY YGGVSSASYA ASIAAAVAPK 
KKIQTTLSNL VVKGTNLIIQ ETRQKLGIPQ KSLSCSEEFK ELMDLPTCGA RNLKQHLAKA 
TASGIMGSPK PAIKSISASA LLKQQKQRML EMRRRKSEEI QKRFLQSSSE VESPAVPSSS 
RQPPAQPPRT GSEFPRLEGA PATMTPKLGR GVLEGDDVLF YDESPPPRPK LSALAEAKKL 
AAITKLRAKG QVLTKTNPNS IKKKQKDPQD ILEVKERVEK NTMFSSQAED ELEPARKKRR 
EQLAYLESEE FQKILKAKSK HTGILKEAEA EMQERYFEPL VKKEQMEEKM RNIREVKCRV 
VTCKTCAYTH FKLLETCVSE QHEYHWHDGV KRFFKCPCGN RSISLDRLPN KHCSNCGLYK 
WERDGMLKEK TGPKIGGETL LPRGEEHAKF LNSLK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MCM10

Associated with

Other Information

The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. PubMed ID: 11095689

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cell cycle-dependent proteolysis and phosphorylation of human Mcm10. PubMed ID: 11602595

Localization of human Mcm10 is spatially and temporally regulated during the S phase. PubMed ID: 15136575

Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication. PubMed ID: 17761813

Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication. PubMed ID: 17699597

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication. PubMed ID: 19696745

Physical interactions between Mcm10, DNA, and DNA polymerase alpha. PubMed ID: 19608746

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability. PubMed ID: 24726359

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Human NK cell deficiency as a result of biallelic mutations in MCM10. PubMed ID: 32865517