Details for: AVPR2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.5014
Cell Significance Index: 8.8600 - Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.2092
Cell Significance Index: 1.7700 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0642
Cell Significance Index: 0.7300 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0023
Cell Significance Index: -0.1000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0026
Cell Significance Index: -4.8700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0048
Cell Significance Index: -3.5100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0056
Cell Significance Index: -3.5600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0062
Cell Significance Index: -4.6200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0063
Cell Significance Index: -4.7600 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0083
Cell Significance Index: -4.5600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0132
Cell Significance Index: -5.9700 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0135
Cell Significance Index: -0.6800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0173
Cell Significance Index: -4.9900 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0175
Cell Significance Index: -0.7200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0189
Cell Significance Index: -3.4100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0228
Cell Significance Index: -3.9000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0229
Cell Significance Index: -4.5400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0237
Cell Significance Index: -4.7600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0258
Cell Significance Index: -3.0100 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0267
Cell Significance Index: -3.4200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0272
Cell Significance Index: -3.3500 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0312
Cell Significance Index: -4.0300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0335
Cell Significance Index: -3.4200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0356
Cell Significance Index: -4.0800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0413
Cell Significance Index: -5.6700 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.0457
Cell Significance Index: -0.6500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0535
Cell Significance Index: -3.9900 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: -0.0603
Cell Significance Index: -0.5500 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.0690
Cell Significance Index: -1.1800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0708
Cell Significance Index: -5.4300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0802
Cell Significance Index: -3.7700 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.0875
Cell Significance Index: -1.2000 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.0953
Cell Significance Index: -1.3700 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.1081
Cell Significance Index: -2.7000 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.1088
Cell Significance Index: -2.1700 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1158
Cell Significance Index: -3.4100 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1177
Cell Significance Index: -3.0000 - Cell Name: endocardial cell (CL0002350)
Fold Change: -0.1203
Cell Significance Index: -0.7100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1261
Cell Significance Index: -5.8800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1262
Cell Significance Index: -7.0800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1334
Cell Significance Index: -3.6300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1400
Cell Significance Index: -7.2700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1408
Cell Significance Index: -4.6100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1472
Cell Significance Index: -4.2200 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1491
Cell Significance Index: -4.7500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1494
Cell Significance Index: -4.1800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1503
Cell Significance Index: -4.0200 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.1508
Cell Significance Index: -2.1900 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1519
Cell Significance Index: -5.3200 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1613
Cell Significance Index: -2.3100 - Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: -0.1614
Cell Significance Index: -2.2100 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1637
Cell Significance Index: -3.9700 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.1639
Cell Significance Index: -2.6300 - Cell Name: endothelial cell (CL0000115)
Fold Change: -0.1668
Cell Significance Index: -2.0500 - Cell Name: precursor B cell (CL0000817)
Fold Change: -0.1673
Cell Significance Index: -2.1700 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1757
Cell Significance Index: -4.6200 - Cell Name: renal principal cell (CL0005009)
Fold Change: -0.1824
Cell Significance Index: -1.9300 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.1856
Cell Significance Index: -4.6300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1862
Cell Significance Index: -4.7900 - Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.1865
Cell Significance Index: -3.0200 - Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
Fold Change: -0.1918
Cell Significance Index: -1.4200 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.1920
Cell Significance Index: -2.4800 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1938
Cell Significance Index: -4.9500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1964
Cell Significance Index: -7.2100 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.2031
Cell Significance Index: -2.1200 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -0.2082
Cell Significance Index: -1.5000 - Cell Name: leukocyte (CL0000738)
Fold Change: -0.2102
Cell Significance Index: -3.5700 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.2116
Cell Significance Index: -2.8200 - Cell Name: microglial cell (CL0000129)
Fold Change: -0.2122
Cell Significance Index: -2.5000 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2238
Cell Significance Index: -4.7500 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.2249
Cell Significance Index: -3.8800 - Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.2319
Cell Significance Index: -2.6900 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.2321
Cell Significance Index: -4.5900 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2322
Cell Significance Index: -3.9800 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2327
Cell Significance Index: -4.3000 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.2328
Cell Significance Index: -5.0300 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.2349
Cell Significance Index: -4.7800 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.2368
Cell Significance Index: -2.8800 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.2371
Cell Significance Index: -4.7600 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2378
Cell Significance Index: -4.6500 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.2429
Cell Significance Index: -3.5900 - Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.2442
Cell Significance Index: -2.7700 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: -0.2454
Cell Significance Index: -3.3700 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.2463
Cell Significance Index: -3.4100 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.2480
Cell Significance Index: -4.8400 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.2584
Cell Significance Index: -3.7800 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.2602
Cell Significance Index: -3.0800 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.2629
Cell Significance Index: -2.8700 - Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.2738
Cell Significance Index: -3.1100 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.2759
Cell Significance Index: -4.7700 - Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: -0.2767
Cell Significance Index: -2.7100 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.2792
Cell Significance Index: -3.0400 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: -0.2838
Cell Significance Index: -3.0600 - Cell Name: granulocyte (CL0000094)
Fold Change: -0.2852
Cell Significance Index: -3.4400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.2914
Cell Significance Index: -7.7800 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: -0.2932
Cell Significance Index: -3.4100 - Cell Name: mesangial cell (CL0000650)
Fold Change: -0.2940
Cell Significance Index: -3.7200 - Cell Name: plasmablast (CL0000980)
Fold Change: -0.2947
Cell Significance Index: -2.7400 - Cell Name: endothelial cell of artery (CL1000413)
Fold Change: -0.2996
Cell Significance Index: -3.1600 - Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: -0.3001
Cell Significance Index: -3.2600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2455555879
Symbol: V2R_HUMAN
Name: Vasopressin V2 receptor
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1415251
Title: Structure and chromosomal localization of the human antidiuretic hormone receptor gene.
PubMed ID: 1415251
PubMed ID: 1534149
Title: Molecular cloning of the receptor for human antidiuretic hormone.
PubMed ID: 1534149
DOI: 10.1038/357333a0
PubMed ID: 7913579
Title: Heterogeneous AVPR2 gene mutations in congenital nephrogenic diabetes insipidus.
PubMed ID: 7913579
PubMed ID: 8735975
Title: Evidence for expression of vasopressin V2 receptor mRNA in human lung.
PubMed ID: 8735975
PubMed ID: 9581826
Title: Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide.
PubMed ID: 9581826
PubMed ID: 19440390
Title: Involvement of the V2 vasopressin receptor in adaptation to limited water supply.
PubMed ID: 19440390
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8882880
Title: Two novel mutations in the aquaporin-2 and the vasopressin V2 receptor genes in patients with congenital nephrogenic diabetes insipidus.
PubMed ID: 8882880
PubMed ID: 9224808
PubMed ID: 21056967
Title: Regulation of M(3) muscarinic receptor expression and function by transmembrane protein 147.
PubMed ID: 21056967
PubMed ID: 23236378
Title: Mammalian alpha arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with beta arrestins.
PubMed ID: 23236378
PubMed ID: 1356229
Title: Molecular identification of the gene responsible for congenital nephrogenic diabetes insipidus.
PubMed ID: 1356229
DOI: 10.1038/359233a0
PubMed ID: 1303271
Title: Mutations in the vasopressin type 2 receptor gene (AVPR2) associated with nephrogenic diabetes insipidus.
PubMed ID: 1303271
DOI: 10.1038/ng1092-99
PubMed ID: 1303257
Title: Mutations in the V2 vasopressin receptor gene are associated with X-linked nephrogenic diabetes insipidus.
PubMed ID: 1303257
DOI: 10.1038/ng1092-103
PubMed ID: 8267567
Title: Two novel mutations in the vasopressin V2 receptor gene in unrelated Japanese kindreds with nephrogenic diabetes insipidus.
PubMed ID: 8267567
PubMed ID: 8479490
Title: A molecular defect in the vasopressin V2-receptor gene causing nephrogenic diabetes insipidus.
PubMed ID: 8479490
PubMed ID: 8514744
Title: Nephrogenic diabetes insipidus. A V2 vasopressin receptor unable to stimulate adenylyl cyclase.
PubMed ID: 8514744
PubMed ID: 8037205
Title: Nature and recurrence of AVPR2 mutations in X-linked nephrogenic diabetes insipidus.
PubMed ID: 8037205
PubMed ID: 7999078
Title: Two novel mutations in the vasopressin V2 receptor gene in patients with congenital nephrogenic diabetes insipidus.
PubMed ID: 7999078
PubMed ID: 7987330
Title: Novel mutations in the V2 vasopressin receptor gene of patients with X-linked nephrogenic diabetes insipidus.
PubMed ID: 7987330
DOI: 10.1093/hmg/3.8.1429
PubMed ID: 7833930
Title: Mutations in the vasopressin V2-receptor gene in three families of Italian descent with nephrogenic diabetes insipidus.
PubMed ID: 7833930
DOI: 10.1093/hmg/3.9.1685
PubMed ID: 8045948
Title: Novel mutations in the V2 vasopressin receptor gene in two pedigrees with congenital nephrogenic diabetes insipidus.
PubMed ID: 8045948
PubMed ID: 7933835
Title: Inheritance of mutations in the V2 receptor gene in thirteen families with nephrogenic diabetes insipidus.
PubMed ID: 7933835
DOI: 10.1038/ki.1994.256
PubMed ID: 7984150
Title: An extracellular congenital nephrogenic diabetes insipidus mutation of the vasopressin receptor reduces cell surface expression, affinity for ligand, and coupling to the Gs/adenylyl cyclase system.
PubMed ID: 7984150
PubMed ID: 8078903
Title: Nephrogenic diabetes insipidus: an X chromosome-linked dominant inheritance pattern with a vasopressin type 2 receptor gene that is structurally normal.
PubMed ID: 8078903
PubMed ID: 7607658
Title: Clinical phenotype of nephrogenic diabetes insipidus in females heterozygous for a vasopressin type 2 receptor mutation.
PubMed ID: 7607658
DOI: 10.1007/bf00214189
PubMed ID: 7560098
Title: Binding-, intracellular transport-, and biosynthesis-defective mutants of vasopressin type 2 receptor in patients with X-linked nephrogenic diabetes insipidus.
PubMed ID: 7560098
DOI: 10.1172/jci118252
PubMed ID: 8929875
Title: Three novel AVPR2 mutations in three Japanese families with X-linked nephrogenic diabetes insipidus.
PubMed ID: 8929875
PubMed ID: 9402087
Title: Mutations in the vasopressin V2 receptor and aquaporin-2 genes in 12 families with congenital nephrogenic diabetes insipidus.
PubMed ID: 9402087
DOI: 10.1681/asn.v8121855
PubMed ID: 9369448
Title: Biochemical basis of partial nephrogenic diabetes insipidus phenotypes.
PubMed ID: 9369448
PubMed ID: 9127330
Title: Six novel mutations in the vasopressin V2 receptor gene causing nephrogenic diabetes insipidus.
PubMed ID: 9127330
DOI: 10.1159/000189581
PubMed ID: 9452109
Title: Mutational analyses of AVPR2 gene in three Japanese families with X-linked nephrogenic diabetes insipidus: two recurrent mutations, R137H and deltaV278, caused by the hypermutability at CpG dinucleotides.
PubMed ID: 9452109
PubMed ID: 10694923
Title: C112R, W323S, N317K mutations in the vasopressin V2 receptor gene in patients with nephrogenic diabetes insipidus.
PubMed ID: 10694923
PubMed ID: 9711877
Title: V2 vasopressin receptor dysfunction in nephrogenic diabetes insipidus caused by different molecular mechanisms.
PubMed ID: 9711877
DOI: 10.1002/(sici)1098-1004(1998)12:3<196::aid-humu7>3.0.co;2-f
PubMed ID: 9773787
Title: Functional studies of twelve mutant V2 vasopressin receptors related to nephrogenic diabetes insipidus: molecular basis of a mild clinical phenotype.
PubMed ID: 9773787
DOI: 10.1681/asn.v9101861
PubMed ID: 9853256
Title: AVPR2 variants and V2 vasopressin receptor function in nephrogenic diabetes insipidus.
PubMed ID: 9853256
PubMed ID: 10477431
Title: Molecular analyses of the vasopressin type 2 receptor and aquaporin-2 genes in Brazilian kindreds with nephrogenic diabetes insipidus.
PubMed ID: 10477431
DOI: 10.1002/(sici)1098-1004(1999)14:3<233::aid-humu6>3.0.co;2-o
PubMed ID: 10820167
Title: Nephrogenic diabetes insipidus: functional analysis of new AVPR2 mutations identified in Italian families.
PubMed ID: 10820167
DOI: 10.1681/asn.v1161033
PubMed ID: 10820168
Title: Report of 33 novel AVPR2 mutations and analysis of 117 families with X-linked nephrogenic diabetes insipidus.
PubMed ID: 10820168
DOI: 10.1681/asn.v1161044
PubMed ID: 10770218
Title: Functional characterization of the molecular defects causing nephrogenic diabetes insipidus in eight families.
PubMed ID: 10770218
PubMed ID: 11026555
Title: Misfolded vasopressin V2 receptors caused by extracellular point mutations entail congenital nephrogenic diabetes insipidus.
PubMed ID: 11026555
PubMed ID: 11232028
Title: The property of a novel V2 receptor mutant in a patient with nephrogenic diabetes insipidus.
PubMed ID: 11232028
PubMed ID: 11793119
Title: Molecular and cellular defects in nephrogenic diabetes insipidus.
PubMed ID: 11793119
PubMed ID: 11916004
Title: Identification of mutations in the arginine vasopressin receptor 2 gene causing nephrogenic diabetes insipidus in Chinese patients.
PubMed ID: 11916004
PubMed ID: 15872203
Title: Nephrogenic syndrome of inappropriate antidiuresis.
PubMed ID: 15872203
DOI: 10.1056/nejmoa042743
PubMed ID: 16845277
Title: Novel mutations underlying nephrogenic diabetes insipidus in Arab families.
PubMed ID: 16845277
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 371
- Mass: 40279
- Checksum: 1F87D20A3C0ECB0D
- Sequence:
MLMASTTSAV PGHPSLPSLP SNSSQERPLD TRDPLLARAE LALLSIVFVA VALSNGLVLA ALARRGRRGH WAPIHVFIGH LCLADLAVAL FQVLPQLAWK ATDRFRGPDA LCRAVKYLQM VGMYASSYMI LAMTLDRHRA ICRPMLAYRH GSGAHWNRPV LVAWAFSLLL SLPQLFIFAQ RNVEGGSGVT DCWACFAEPW GRRTYVTWIA LMVFVAPTLG IAACQVLIFR EIHASLVPGP SERPGGRRRG RRTGSPGEGA HVSAAVAKTV RMTLVIVVVY VLCWAPFFLV QLWAAWDPEA PLEGAPFVLL MLLASLNSCT NPWIYASFSS SVSSELRSLL CCARGRTPPS LGPQDESCTT ASSSLAKDTS S
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.