PARL | ENSG00000175193 | NCBI 55486

Details for: PARL

Gene ID: 55486

Symbol: PARL

Ensembl ID: ENSG00000175193

Description: presenilin associated rhomboid like

Associated with

Mitochondrial calcium ion transport
(R-HSA-8949215)
Processing of smdt1
(R-HSA-8949664)
Transport of small molecules
(R-HSA-382551)
Endopeptidase activity
(GO:0004175)
Membrane protein proteolysis
(GO:0033619)
Mitochondrial fusion
(GO:0008053)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrion
(GO:0005739)
Negative regulation of intrinsic apoptotic signaling pathway
(GO:2001243)
Negative regulation of release of cytochrome c from mitochondria
(GO:0090201)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein processing
(GO:0016485)
Proteolysis
(GO:0006508)
Regulation of mitochondrion organization
(GO:0010821)
Regulation of mitophagy
(GO:1901524)
Regulation of protein targeting to mitochondrion
(GO:1903214)
Regulation of proteolysis
(GO:0030162)
Regulation of reactive oxygen species metabolic process
(GO:2000377)
Serine-type endopeptidase activity
(GO:0004252)
Signal peptide processing
(GO:0006465)

Other Information

Proteins

Presenilin-associated rhomboid-like protein, mitochondrial
C9JNP8_HUMAN

Genular Protein ID: 2585374708

Symbol: PARL_HUMAN

Name: Presenilin-associated rhomboid-like protein, mitochondrial

UniProtKB Accession Codes:

Q9H300 Q96CQ4 Q9BTJ6 Q9P1E3

Database IDs:

Citations:

PubMed ID: 12214059

Title: PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of presenilin-1 and -2.

PubMed ID: 12214059

DOI: 10.3233/jad-2001-3203

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14732705

Title: Self-regulated cleavage of the mitochondrial intramembrane-cleaving protease PARL yields Pbeta, a nuclear-targeted peptide.

PubMed ID: 14732705

DOI: 10.1074/jbc.m313756200

PubMed ID: 17116872

Title: Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology.

PubMed ID: 17116872

DOI: 10.1073/pnas.0604983103

PubMed ID: 22354088

Title: Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment.

PubMed ID: 22354088

DOI: 10.1038/embor.2012.14

PubMed ID: 22915595

Title: Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.

PubMed ID: 22915595

DOI: 10.1074/jbc.m112.357509

PubMed ID: 28288130

Title: PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis.

PubMed ID: 28288130

DOI: 10.1038/ncb3488

PubMed ID: 32573439

Title: Skd3 (human ClpB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations.

PubMed ID: 32573439

DOI: 10.7554/elife.55279

Sequence Information:

Length: 379
Mass: 42190
Checksum: 2B07EF04C7130B0B
Sequence:

MAWRGWAQRG WGCGQAWGAS VGGRSCEELT AVLTPPQLLG RRFNFFIQQK CGFRKAPRKV 
EPRRSDPGTS GEAYKRSALI PPVEETVFYP SPYPIRSLIK PLFFTVGFTG CAFGSAAIWQ 
YESLKSRVQS YFDGIKADWL DSIRPQKEGD FRKEINKWWN NLSDGQRTVT GIIAANVLVF 
CLWRVPSLQR TMIRYFTSNP ASKVLCSPML LSTFSHFSLF HMAANMYVLW SFSSSIVNIL 
GQEQFMAVYL SAGVISNFVS YVGKVATGRY GPSLGASGAI MTVLAAVCTK IPEGRLAIIF 
LPMFTFTAGN ALKAIIAMDT AGMILGWKFF DHAAHLGGAL FGIWYVTYGH ELIWKNREPL 
VKIWHEIRTN GPKKGGGSK

Genular Protein ID: 1945481326

Symbol: C9JNP8_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9JNP8

Database IDs:

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

Length: 295
Mass: 33052
Checksum: 5D677632AB3095A6
Sequence:

MAWRGWAQRG WGCGQAWGAS VGGRSCEELT AVLTPPQLLG RRFNFFIQQK CGFRKAPRKV 
EPRRSDPGTS GEAYKRSALI PPVEETVFYP SPYPIRSLIK PLFFTVGFTG CAFGSAAIWQ 
YESLKSRVQS YFDGIKADWL DSIRPQKEGD FRKEINKWWN NLSDGQRTVT GIIAANVLVF 
CLWRVPSLQR TMIRYFTSNP ASSVISNFVS YVGKVATGRY GPSLGAALKA IIAMDTAGMI 
LGWKFFDHAA HLGGALFGIW YVTYGHELIW KNREPLVKIW HEIRTNGPKK GGGSK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PARL

Associated with

Other Information

PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of presenilin-1 and -2. PubMed ID: 12214059

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Self-regulated cleavage of the mitochondrial intramembrane-cleaving protease PARL yields Pbeta, a nuclear-targeted peptide. PubMed ID: 14732705

Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology. PubMed ID: 17116872

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment. PubMed ID: 22354088

Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5. PubMed ID: 22915595

PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis. PubMed ID: 28288130

Skd3 (human ClpB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations. PubMed ID: 32573439

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712