Details for: TRPV6

Gene ID: 55503

Symbol: TRPV6

Ensembl ID: ENSG00000165125

Description: transient receptor potential cation channel subfamily V member 6

Associated with

Other Information

Genular Protein ID: 71319634

Symbol: TRPV6_HUMAN

Name: Transient receptor potential cation channel subfamily V member 6

UniProtKB Accession Codes:

Q9H1D0 A4D2I8 Q8TDL3 Q8WXR8 Q96LC5 Q9H1D1 Q9H296

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 3 EMBL 10 EMDB 19 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 27 PDBsum 19 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11097838

Title: Human calcium transport protein CaT1.

PubMed ID: 11097838

DOI: 10.1006/bbrc.2000.3716

PubMed ID: 11545681

Title: 1,25-dihydroxyvitamin D3 increases the expression of the CaT1 epithelial calcium channel in the Caco-2 human intestinal cell line.

PubMed ID: 11545681

DOI: 10.1186/1472-6793-1-11

PubMed ID: 11549322

Title: Structural conservation of the genes encoding CaT1, CaT2, and related cation channels.

PubMed ID: 11549322

DOI: 10.1006/geno.2001.6606

PubMed ID: 11278579

Title: Expression of CaT-like, a novel calcium selective channel, correlates with the malignancy of prostate cancer.

PubMed ID: 11278579

DOI: 10.1074/jbc.m009895200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 11248124

Title: Competitive regulation of CaT-like-mediated Ca2+ entry by protein kinase C and calmodulin.

PubMed ID: 11248124

DOI: 10.1073/pnas.051511398

PubMed ID: 15184369

Title: Ca2+ dependence of the Ca2+-selective TRPV6 channel.

PubMed ID: 15184369

DOI: 10.1074/jbc.m404679200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23612980

Title: The in vivo TRPV6 protein starts at a non-AUG triplet, decoded as methionine, upstream of canonical initiation at AUG.

PubMed ID: 23612980

DOI: 10.1074/jbc.m113.469726

PubMed ID: 25559186

Title: TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity.

PubMed ID: 25559186

DOI: 10.1083/jcb.201402076

PubMed ID: 29258289

Title: Opening of the human epithelial calcium channel TRPV6.

PubMed ID: 29258289

DOI: 10.1038/nature25182

PubMed ID: 29861107

Title: TRPV6 Variants Interfere with Maternal-Fetal Calcium Transport through the Placenta and Cause Transient Neonatal Hyperparathyroidism.

PubMed ID: 29861107

DOI: 10.1016/j.ajhg.2018.04.006

PubMed ID: 30820485

Title: TRPV6 gene mutation in a dizygous twin with transient neonatal hyperparathyroidism.

PubMed ID: 30820485

DOI: 10.1210/js.2018-00374

Sequence Information:

  • Length: 765
  • Mass: 87286
  • Checksum: 626D515E12112546
  • Sequence:
    • MGPLQGDGGP ALGGADVAPR LSPVRVWPRP QAPKEPALHP MGLSLPKEKG LILCLWSKFC 
RWFQRRESWA QSRDEQNLLQ QKRIWESPLL LAAKDNDVQA LNKLLKYEDC KVHQRGAMGE 
TALHIAALYD NLEAAMVLME AAPELVFEPM TSELYEGQTA LHIAVVNQNM NLVRALLARR 
ASVSARATGT AFRRSPCNLI YFGEHPLSFA ACVNSEEIVR LLIEHGADIR AQDSLGNTVL 
HILILQPNKT FACQMYNLLL SYDRHGDHLQ PLDLVPNHQG LTPFKLAGVE GNTVMFQHLM 
QKRKHTQWTY GPLTSTLYDL TEIDSSGDEQ SLLELIITTK KREARQILDQ TPVKELVSLK 
WKRYGRPYFC MLGAIYLLYI ICFTMCCIYR PLKPRTNNRT SPRDNTLLQQ KLLQEAYMTP 
KDDIRLVGEL VTVIGAIIIL LVEVPDIFRM GVTRFFGQTI LGGPFHVLII TYAFMVLVTM 
VMRLISASGE VVPMSFALVL GWCNVMYFAR GFQMLGPFTI MIQKMIFGDL MRFCWLMAVV 
ILGFASAFYI IFQTEDPEEL GHFYDYPMAL FSTFELFLTI IDGPANYNVD LPFMYSITYA 
AFAIIATLLM LNLLIAMMGD THWRVAHERD ELWRAQIVAT TVMLERKLPR CLWPRSGICG 
REYGLGDRWF LRVEDRQDLN RQRIQRYAQA FHTRGSEDLD KDSVEKLELG CPFSPHLSLP 
MPSVSRSTSR SSANWERLRQ GTLRRDLRGI INRGLEDGES WEYQI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.