MACROH2A2 | ENSG00000099284 | NCBI 55506

Details for: MACROH2A2

Gene ID: 55506

Symbol: MACROH2A2

Ensembl ID: ENSG00000099284

Description: macroH2A.2 histone

Associated with

Barr body
(GO:0001740)
Brain development
(GO:0007420)
Chromatin
(GO:0000785)
Chromatin dna binding
(GO:0031490)
Chromosome, telomeric region
(GO:0000781)
Establishment of protein localization to chromatin
(GO:0071169)
Extracellular exosome
(GO:0070062)
Heterochromatin organization
(GO:0070828)
Negative regulation of gene expression, epigenetic
(GO:0045814)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of transcription of nucleolar large rrna by rna polymerase i
(GO:1901837)
Nucleoplasm
(GO:0005654)
Nucleosomal dna binding
(GO:0031492)
Nucleosome
(GO:0000786)
Nucleosome assembly
(GO:0006334)
Nucleus
(GO:0005634)
Positive regulation of keratinocyte differentiation
(GO:0045618)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sex-chromosome dosage compensation
(GO:0007549)
Structural constituent of chromatin
(GO:0030527)
Transcription cis-regulatory region binding
(GO:0000976)

Other Information

Proteins

Core histone macro-H2A.2

Genular Protein ID: 1472850249

Symbol: H2AW_HUMAN

Name: Core histone macro-H2A.2

UniProtKB Accession Codes:

Q9P0M6 Q5SQT2

Database IDs:

Citations:

PubMed ID: 11331621

Title: Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant.

PubMed ID: 11331621

DOI: 10.1093/hmg/10.10.1101

PubMed ID: 11262398

Title: MACROH2A2, a new member of the MACROH2A core histone family.

PubMed ID: 11262398

DOI: 10.1074/jbc.m010919200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15621527

Title: Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA.

PubMed ID: 15621527

DOI: 10.1016/j.devcel.2004.10.019

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

Length: 372
Mass: 40058
Checksum: C4B35CD156031AF1
Sequence:

MSGRSGKKKM SKLSRSARAG VIFPVGRLMR YLKKGTFKYR ISVGAPVYMA AVIEYLAAEI 
LELAGNAARD NKKARIAPRH ILLAVANDEE LNQLLKGVTI ASGGVLPRIH PELLAKKRGT 
KGKSETILSP PPEKRGRKAT SGKKGGKKSK AAKPRTSKKS KPKDSDKEGT SNSTSEDGPG 
DGFTILSSKS LVLGQKLSLT QSDISHIGSM RVEGIVHPTT AEIDLKEDIG KALEKAGGKE 
FLETVKELRK SQGPLEVAEA AVSQSSGLAA KFVIHCHIPQ WGSDKCEEQL EETIKNCLSA 
AEDKKLKSVA FPPFPSGRNC FPKQTAAQVT LKAISAHFDD SSASSLKNVY FLLFDSESIG 
IYVQEMAKLD AK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MACROH2A2

Associated with

Other Information

Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant. PubMed ID: 11331621

MACROH2A2, a new member of the MACROH2A core histone family. PubMed ID: 11262398

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. PubMed ID: 15621527

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. PubMed ID: 25755297

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733