SMPD3 | ENSG00000103056 | NCBI 55512

Details for: SMPD3

Gene ID: 55512

Symbol: SMPD3

Ensembl ID: ENSG00000103056

Description: sphingomyelin phosphodiesterase 3

Associated with

Death receptor signaling
(R-HSA-73887)
Glycosphingolipid catabolism
(R-HSA-9840310)
Glycosphingolipid metabolism
(R-HSA-1660662)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Signal transduction
(R-HSA-162582)
Sphingolipid metabolism
(R-HSA-428157)
Tnfr1-mediated ceramide production
(R-HSA-5626978)
Tnf signaling
(R-HSA-75893)
Bmp signaling pathway
(GO:0030509)
Bone growth
(GO:0098868)
Bone mineralization
(GO:0030282)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to magnesium ion
(GO:0071286)
Cellular response to oxidised low-density lipoprotein particle stimulus
(GO:0140052)
Cellular response to peptide
(GO:1901653)
Cellular response to redox state
(GO:0071461)
Cellular response to tumor necrosis factor
(GO:0071356)
Ceramide metabolic process
(GO:0006672)
Chondrocyte development involved in endochondral bone morphogenesis
(GO:0003433)
Collagen metabolic process
(GO:0032963)
Cytoplasm
(GO:0005737)
Dentinogenesis
(GO:0097187)
Dna biosynthetic process
(GO:0071897)
Endochondral ossification
(GO:0001958)
Extracellular matrix assembly
(GO:0085029)
Extracellular region
(GO:0005576)
G1 to g0 transition
(GO:0070314)
Golgi cis cisterna
(GO:0000137)
Golgi membrane
(GO:0000139)
Hematopoietic progenitor cell differentiation
(GO:0002244)
Identical protein binding
(GO:0042802)
Lung alveolus development
(GO:0048286)
Metal ion binding
(GO:0046872)
Mitotic nuclear division
(GO:0140014)
Multicellular organism growth
(GO:0035264)
Negative regulation of hyaluronan biosynthetic process
(GO:1900126)
Neutral sphingomyelin phosphodiesterase activity
(GO:0061751)
Peptide hormone secretion
(GO:0030072)
Phosphatidic acid binding
(GO:0070300)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Phosphatidylserine binding
(GO:0001786)
Phosphoric diester hydrolase activity
(GO:0008081)
Plasma membrane
(GO:0005886)
Platelet-derived growth factor receptor signaling pathway
(GO:0048008)
Polysaccharide transport
(GO:0015774)
Positive regulation of exosomal secretion
(GO:1903543)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Protein binding
(GO:0005515)
Regulation of cartilage development
(GO:0061035)
Regulation of leukocyte migration
(GO:0002685)
Regulation of protein phosphorylation
(GO:0001932)
Sphingolipid mediated signaling pathway
(GO:0090520)
Sphingomyelin catabolic process
(GO:0006685)
Sphingomyelin metabolic process
(GO:0006684)
Sphingomyelin phosphodiesterase activity
(GO:0004767)

Other Information

Proteins

Neutral sphingomyelinase 2
A8K0T6_HUMAN

Genular Protein ID: 2749391199

Symbol: NSMA2_HUMAN

Name: Neutral sphingomyelinase 2

UniProtKB Accession Codes:

Q9NY59 B7ZL82 Q2M1S8

Database IDs:

Citations:

PubMed ID: 10823942

Title: Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase.

PubMed ID: 10823942

DOI: 10.1073/pnas.97.11.5895

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14741383

Title: Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases.

PubMed ID: 14741383

DOI: 10.1016/s0014-5793(03)01523-0

PubMed ID: 15051724

Title: Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells.

PubMed ID: 15051724

DOI: 10.1074/jbc.m313662200

PubMed ID: 17349629

Title: Analysis of membrane topology of neutral sphingomyelinase 2.

PubMed ID: 17349629

DOI: 10.1016/j.febslet.2007.02.046

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 655
Mass: 71081
Checksum: C06401571633C48E
Sequence:

MVLYTTPFPN SCLSALHCVS WALIFPCYWL VDRLAASFIP TTYEKRQRAD DPCCLQLLCT 
ALFTPIYLAL LVASLPFAFL GFLFWSPLQS ARRPYIYSRL EDKGLAGGAA LLSEWKGTGP 
GKSFCFATAN VCLLPDSLAR VNNLFNTQAR AKEIGQRIRN GAARPQIKIY IDSPTNTSIS 
AASFSSLVSP QGGDGVARAV PGSIKRTASV EYKGDGGRHP GDEAANGPAS GDPVDSSSPE 
DACIVRIGGE EGGRPPEADD PVPGGQARNG AGGGPRGQTP NHNQQDGDSG SLGSPSASRE 
SLVKGRAGPD TSASGEPGAN SKLLYKASVV KKAAARRRRH PDEAFDHEVS AFFPANLDFL 
CLQEVFDKRA ATKLKEQLHG YFEYILYDVG VYGCQGCCSF KCLNSGLLFA SRYPIMDVAY 
HCYPNKCNDD ALASKGALFL KVQVGSTPQD QRIVGYIACT HLHAPQEDSA IRCGQLDLLQ 
DWLADFRKST SSSSAANPEE LVAFDVVCGD FNFDNCSSDD KLEQQHSLFT HYRDPCRLGP 
GEEKPWAIGT LLDTNGLYDE DVCTPDNLQK VLESEEGRRE YLAFPTSKSS GQKGRKELLK 
GNGRRIDYML HAEEGLCPDW KAEVEEFSFI TQLSGLTDHL PVAMRLMVSS GEEEA

Genular Protein ID: 1112265422

Symbol: A8K0T6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K0T6

Database IDs:

Sequence Information:

Length: 655
Mass: 71111
Checksum: CBFAC309DFF3C1CA
Sequence:

MVLYTTPFPN SCLSALHCVS WALIFPCYWL VDRLAASFIP TTYEKRQRAD DPCCLQLLCT 
ALFTPIYLAL LVASLPFAFL GFLFWSPLQS ARRPYIYSRL EDKGLAGGAA LLSEWKGTGP 
GKSFCFATAN VCLLPDSLAR VNNLFNTQAR AKEIGQRIRN GAARPQIKIY IDSPTNTSIS 
AASFSSLVSP QGGDGVARAV PGSIKRTASV EYKGDGGRHP GDEAANGPAS GDPVDSSSPE 
DACIVRIGGE EGGRPPEADD PVPGGQARNG AGGGPRSQTP NHNQQDGDSG SLGSPSASRE 
SLVKGRAGPD TSASGEPGAN SKLLYKASVV KKAAARRRRH PDEAFDHEVS AFFPANLDFL 
CLQEVFDKRA ATKLKEQLHG YFEYILYDVG VYGCQGCCSF KCLNSGLLFA SRYPIMDVAY 
HCYPNKCNDD ALASKGALFL KVQVGSTPQD QRIVGYIACT HLHAPQEDSA IRCGQLDLLQ 
DWLADFRKST SSSSAANPEE LVAFDVVCGD FNFDNCSSDD KLEQQHSLFT HYRDPCRLGP 
GEEKPWAIGT LLDTNGLYDE DVCTPDNLQK VLESEEGRRE YLAFPTSKSS GQKGRKELLK 
GNGRRIDYML HAEEGLCPDW KAEVEEFSFI TQLSGLTDHL PVAMRLMVSS GEEEA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SMPD3

Associated with

Other Information

Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase. PubMed ID: 10823942

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases. PubMed ID: 14741383

Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells. PubMed ID: 15051724

Analysis of membrane topology of neutral sphingomyelinase 2. PubMed ID: 17349629

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569