Details for: FEM1A

Gene ID: 55527

Symbol: FEM1A

Ensembl ID: ENSG00000141965

Description: fem-1 homolog A

Associated with

Other Information

Genular Protein ID: 2836177363

Symbol: FEM1A_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BSK4 B2RDI3 Q711P8 Q9NPN7 Q9NPW8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16424369

Title: A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling.

PubMed ID: 16424369

DOI: 10.1161/01.res.0000204451.88147.96

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16254458

Title: The Fem1a gene is downregulated in Rhabdomyosarcoma.

PubMed ID: 16254458

DOI: 10.1159/000089261

PubMed ID: 19406122

Title: Fem1a is a mitochondrial protein up-regulated upon ischemia-reperfusion injury.

PubMed ID: 19406122

DOI: 10.1016/j.febslet.2009.04.035

PubMed ID: 28118078

Title: FEM1 proteins are ancient regulators of SLBP degradation.

PubMed ID: 28118078

DOI: 10.1080/15384101.2017.1284715

PubMed ID: 29779948

Title: The eukaryotic proteome is shaped by E3 ubiquitin ligases targeting C-terminal degrons.

PubMed ID: 29779948

DOI: 10.1016/j.cell.2018.04.028

PubMed ID: 33398168

Title: Molecular basis for arginine C-terminal degron recognition by Cul2FEM1 E3 ligase.

PubMed ID: 33398168

DOI: 10.1038/s41589-020-00704-3

PubMed ID: 33398170

Title: Molecular basis for ubiquitin ligase CRL2FEM1C-mediated recognition of C-degron.

PubMed ID: 33398170

DOI: 10.1038/s41589-020-00703-4

PubMed ID: 16390781

Title: FEM1A is a candidate gene for polycystic ovary syndrome.

PubMed ID: 16390781

DOI: 10.1080/09513590500431458

Sequence Information:

  • Length: 669
  • Mass: 73639
  • Checksum: FF0010DE5207D48F
  • Sequence:
    • MDLRTAVYNA ARDGKLQLLQ KLLSGRSREE LDELTGEVAG GGTPLLIAAR YGHLDVVEYL 
VDRCGASVEA GGSVHFDGET IEGAPPLWAA SAAGHLDVVR SLLRRGASVN RTTRTNSTPL 
RAACFDGHLE VVRYLVGEHQ ADLEVANRHG HTCLMISCYK GHREIARYLL EQGAQVNRRS 
AKGNTALHDC AESGSLEILQ LLLGCKARME RDGYGMTPLL AASVTGHTNI VEYLIQEQPG 
QEQVAGGEAQ PGLPQEDPST SQGCAQPQGA PCCSSSPEEP LNGESYESCC PTSREAAVEA 
LELLGATYVD KKRDLLGALK HWRRAMELRH QGGEYLPKPE PPQLVLAYDY SREVNTTEEL 
EALITDPDEM RMQALLIRER ILGPSHPDTS YYIRYRGAVY ADSGNFERCI RLWKYALDMQ 
QSNLEPLSPM TASSFLSFAE LFSYVLQDRA AKGSLGTQIG FADLMGVLTK GVREVERALQ 
LPREPGDSAQ FTKALAIILH LLYLLEKVEC TPSQEHLKHQ TVYRLLKCAP RGKNGFTPLH 
MAVDKDTTNV GRYPVGRFPS LHVVKVLLDC GADPDSRDFD NNTPLHIAAQ NNCPAIMNAL 
IEAGAHMDAT NAFKKTAYEL LDEKLLARGT MQPFNYVTLQ CLAARALDKN KIPYKGFIPE 
DLEAFIELH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.