PRIM1 | ENSG00000198056 | NCBI 5557

Details for: PRIM1

Gene ID: 5557

Symbol: PRIM1

Ensembl ID: ENSG00000198056

Description: DNA primase subunit 1

Associated with

Activation of the pre-replicative complex
(R-HSA-68962)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Chromosome maintenance
(R-HSA-73886)
Defective pyroptosis
(R-HSA-9710421)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Dna strand elongation
(R-HSA-69190)
E2f mediated regulation of dna replication
(R-HSA-113510)
Extension of telomeres
(R-HSA-180786)
G1/s transition
(R-HSA-69206)
Inhibition of replication initiation of damaged dna by rb1/e2f1
(R-HSA-113501)
Lagging strand synthesis
(R-HSA-69186)
Leading strand synthesis
(R-HSA-69109)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Polymerase switching
(R-HSA-69091)
Polymerase switching on the c-strand of the telomere
(R-HSA-174411)
Processive synthesis on the lagging strand
(R-HSA-69183)
Removal of the flap intermediate
(R-HSA-69166)
S phase
(R-HSA-69242)
Synthesis of dna
(R-HSA-69239)
Telomere c-strand (lagging strand) synthesis
(R-HSA-174417)
Telomere c-strand synthesis initiation
(R-HSA-174430)
Telomere maintenance
(R-HSA-157579)
Alpha dna polymerase:primase complex
(GO:0005658)
Dna primase activity
(GO:0003896)
Dna replication, synthesis of rna primer
(GO:0006269)
Dna replication initiation
(GO:0006270)
Magnesium ion binding
(GO:0000287)
Membrane
(GO:0016020)
Nucleoplasm
(GO:0005654)
Protein binding
(GO:0005515)
Ribonucleotide binding
(GO:0032553)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

DNA primase small subunit

Genular Protein ID: 3240350368

Symbol: PRI1_HUMAN

Name: DNA primase small subunit

UniProtKB Accession Codes:

P49642

Database IDs:

Citations:

PubMed ID: 8026492

Title: DNA replication in vitro by recombinant DNA-polymerase-alpha-primase.

PubMed ID: 8026492

DOI: 10.1111/j.1432-1033.1994.tb18925.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9268648

Title: Mapping of the human DNA primase 1 (PRIM1) to chromosome 12q13.

PubMed ID: 9268648

DOI: 10.1006/geno.1997.4833

PubMed ID: 9705292

Title: Primase activity of human DNA polymerase alpha-primase. Divalent cations stabilize the enzyme activity of the p48 subunit.

PubMed ID: 9705292

DOI: 10.1074/jbc.273.34.21608

PubMed ID: 17893144

Title: An iron-sulfur cluster in the C-terminal domain of the p58 subunit of human DNA primase.

PubMed ID: 17893144

DOI: 10.1074/jbc.m705826200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24043831

Title: Structures of human primase reveal design of nucleotide elongation site and mode of Pol alpha tethering.

PubMed ID: 24043831

DOI: 10.1073/pnas.1311185110

PubMed ID: 24239947

Title: Insights into eukaryotic primer synthesis from structures of the p48 subunit of human DNA primase.

PubMed ID: 24239947

DOI: 10.1016/j.jmb.2013.11.007

PubMed ID: 25550159

Title: Crystal structure of the human primase.

PubMed ID: 25550159

DOI: 10.1074/jbc.m114.624742

PubMed ID: 26975377

Title: Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome.

PubMed ID: 26975377

DOI: 10.1074/jbc.m116.717405

PubMed ID: 31479243

Title: Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.

PubMed ID: 31479243

DOI: 10.1021/acschembio.9b00367

PubMed ID: 33060134

Title: PRIM1 deficiency causes a distinctive primordial dwarfism syndrome.

PubMed ID: 33060134

DOI: 10.1101/gad.340190.120

Sequence Information:

Length: 420
Mass: 49902
Checksum: 9B5AC900E0C3CCE8
Sequence:

METFDPTELP ELLKLYYRRL FPYSQYYRWL NYGGVIKNYF QHREFSFTLK DDIYIRYQSF 
NNQSDLEKEM QKMNPYKIDI GAVYSHRPNQ HNTVKLGAFQ AQEKELVFDI DMTDYDDVRR 
CCSSADICPK CWTLMTMAIR IIDRALKEDF GFKHRLWVYS GRRGVHCWVC DESVRKLSSA 
VRSGIVEYLS LVKGGQDVKK KVHLSEKIHP FIRKSINIIK KYFEEYALVN QDILENKESW 
DKILALVPET IHDELQQSFQ KSHNSLQRWE HLKKVASRYQ NNIKNDKYGP WLEWEIMLQY 
CFPRLDINVS KGINHLLKSP FSVHPKTGRI SVPIDLQKVD QFDPFTVPTI SFICRELDAI 
STNEEEKEEN EAESDVKHRT RDYKKTSLAP YVKVFEHFLE NLDKSRKGEL LKKSDLQKDF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PRIM1

Associated with

Other Information

DNA replication in vitro by recombinant DNA-polymerase-alpha-primase. PubMed ID: 8026492

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mapping of the human DNA primase 1 (PRIM1) to chromosome 12q13. PubMed ID: 9268648

Primase activity of human DNA polymerase alpha-primase. Divalent cations stabilize the enzyme activity of the p48 subunit. PubMed ID: 9705292

An iron-sulfur cluster in the C-terminal domain of the p58 subunit of human DNA primase. PubMed ID: 17893144

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Structures of human primase reveal design of nucleotide elongation site and mode of Pol alpha tethering. PubMed ID: 24043831

Insights into eukaryotic primer synthesis from structures of the p48 subunit of human DNA primase. PubMed ID: 24239947

Crystal structure of the human primase. PubMed ID: 25550159

Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome. PubMed ID: 26975377

Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine. PubMed ID: 31479243

PRIM1 deficiency causes a distinctive primordial dwarfism syndrome. PubMed ID: 33060134