CHRNA9 | ENSG00000174343 | NCBI 55584

Details for: CHRNA9

Gene ID: 55584

Symbol: CHRNA9

Ensembl ID: ENSG00000174343

Description: cholinergic receptor nicotinic alpha 9 subunit

Associated with

Acetylcholine binding and downstream events
(R-HSA-181431)
Acetylcholine inhibits contraction of outer hair cells
(R-HSA-9667769)
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
(R-HSA-629594)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Postsynaptic nicotinic acetylcholine receptors
(R-HSA-622327)
Sensory perception
(R-HSA-9709957)
Sensory processing of sound
(R-HSA-9659379)
Sensory processing of sound by outer hair cells of the cochlea
(R-HSA-9662361)
Transmission across chemical synapses
(R-HSA-112315)
Acetylcholine-gated channel complex
(GO:0005892)
Acetylcholine-gated monoatomic cation-selective channel activity
(GO:0022848)
Calcium channel activity
(GO:0005262)
Calcium ion transmembrane transport
(GO:0070588)
Chemical synaptic transmission
(GO:0007268)
Detection of mechanical stimulus involved in sensory perception of sound
(GO:0050910)
Excitatory postsynaptic potential
(GO:0060079)
Inner ear morphogenesis
(GO:0042472)
Membrane depolarization
(GO:0051899)
Monoatomic ion transmembrane transport
(GO:0034220)
Nervous system process
(GO:0050877)
Neuron projection
(GO:0043005)
Plasma membrane
(GO:0005886)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Postsynaptic membrane
(GO:0045211)
Protein binding
(GO:0005515)
Regulation of membrane potential
(GO:0042391)
Response to auditory stimulus
(GO:0010996)
Synapse
(GO:0045202)
Transmembrane signaling receptor activity
(GO:0004888)
Transmembrane transporter complex
(GO:1902495)

Other Information

Proteins

Neuronal acetylcholine receptor subunit alpha-9

Genular Protein ID: 3615952997

Symbol: ACHA9_HUMAN

Name: Neuronal acetylcholine receptor subunit alpha-9

UniProtKB Accession Codes:

Q9UGM1 Q14CY7 Q4W5A2 Q9NYV2

Database IDs:

Citations:

PubMed ID: 11752216

Title: A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit.

PubMed ID: 11752216

DOI: 10.1124/mol.61.1.150

PubMed ID: 12697997

Title: Chromosome location and characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) gene.

PubMed ID: 12697997

DOI: 10.1159/000069804

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11021840

Title: Novel human alpha9 acetylcholine receptor regulating keratinocyte adhesion is targeted by Pemphigus vulgaris autoimmunity.

PubMed ID: 11021840

DOI: 10.1016/s0002-9440(10)64651-2

PubMed ID: 15531379

Title: Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes.

PubMed ID: 15531379

DOI: 10.1016/j.lfs.2004.05.031

PubMed ID: 22774872

Title: Molecular basis for the differential sensitivity of rat and human alpha9alpha10 nAChRs to alpha-conotoxin RgIA.

PubMed ID: 22774872

DOI: 10.1111/j.1471-4159.2012.07867.x

PubMed ID: 25282151

Title: Crystal structures of free and antagonist-bound states of human alpha9 nicotinic receptor extracellular domain.

PubMed ID: 25282151

DOI: 10.1038/nsmb.2900

Sequence Information:

Length: 479
Mass: 54807
Checksum: AA6B46B559D6111D
Sequence:

MNWSHSCISF CWIYFAASRL RAAETADGKY AQKLFNDLFE DYSNALRPVE DTDKVLNVTL 
QITLSQIKDM DERNQILTAY LWIRQIWHDA YLTWDRDQYD GLDSIRIPSD LVWRPDIVLY 
NKADDESSEP VNTNVVLRYD GLITWDAPAI TKSSCVVDVT YFPFDNQQCN LTFGSWTYNG 
NQVDIFNALD SGDLSDFIED VEWEVHGMPA VKNVISYGCC SEPYPDVTFT LLLKRRSSFY 
IVNLLIPCVL ISFLAPLSFY LPAASGEKVS LGVTILLAMT VFQLMVAEIM PASENVPLIG 
KYYIATMALI TASTALTIMV MNIHFCGAEA RPVPHWARVV ILKYMSRVLF VYDVGESCLS 
PHHSRERDHL TKVYSKLPES NLKAARNKDL SRKKDMNKRL KNDLGCQGKN PQEAESYCAQ 
YKVLTRNIEY IAKCLKDHKA TNSKGSEWKK VAKVIDRFFM WIFFIMVFVM TILIIARAD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CHRNA9

Associated with

Other Information

A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit. PubMed ID: 11752216

Chromosome location and characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) gene. PubMed ID: 12697997

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Novel human alpha9 acetylcholine receptor regulating keratinocyte adhesion is targeted by Pemphigus vulgaris autoimmunity. PubMed ID: 11021840

Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes. PubMed ID: 15531379

Molecular basis for the differential sensitivity of rat and human alpha9alpha10 nAChRs to alpha-conotoxin RgIA. PubMed ID: 22774872

Crystal structures of free and antagonist-bound states of human alpha9 nicotinic receptor extracellular domain. PubMed ID: 25282151