OTUD5 | ENSG00000068308 | NCBI 55593

Details for: OTUD5

Gene ID: 55593

Symbol: OTUD5

Ensembl ID: ENSG00000068308

Description: OTU deubiquitinase 5

Associated with

Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-HSA-168928)
Deubiquitination
(R-HSA-5688426)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Metabolism of proteins
(R-HSA-392499)
Negative regulators of ddx58/ifih1 signaling
(R-HSA-936440)
Ovarian tumor domain proteases
(R-HSA-5689896)
Post-translational protein modification
(R-HSA-597592)
Cysteine-type deubiquitinase activity
(GO:0004843)
Cytosol
(GO:0005829)
Deubiquitinase activity
(GO:0101005)
K48-linked deubiquitinase activity
(GO:1990380)
K63-linked deubiquitinase activity
(GO:0061578)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of type i interferon production
(GO:0032480)
Neural crest cell differentiation
(GO:0014033)
Nucleus
(GO:0005634)
Positive regulation of torc1 signaling
(GO:1904263)
Positive regulation of torc2 signaling
(GO:1904515)
Protein deubiquitination
(GO:0016579)
Protein k48-linked deubiquitination
(GO:0071108)
Protein k63-linked deubiquitination
(GO:0070536)
Proteolysis
(GO:0006508)
Response to lipopolysaccharide
(GO:0032496)

Other Information

Proteins

Deubiquitinating enzyme A

Genular Protein ID: 2189812671

Symbol: OTUD5_HUMAN

Name: Deubiquitinating enzyme A

UniProtKB Accession Codes:

Q96G74 B4DGG7 G5E9D7 Q4KMN9 Q8N6T5 Q9H650 Q9H9U0 Q9NT65

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17991829

Title: DUBA: a deubiquitinase that regulates type I interferon production.

PubMed ID: 17991829

DOI: 10.1126/science.1145918

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23827681

Title: OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.

PubMed ID: 23827681

DOI: 10.1016/j.cell.2013.05.046

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 33110214

Title: Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways.

PubMed ID: 33110214

DOI: 10.1038/s41418-020-00649-z

PubMed ID: 33523931

Title: Linkage-specific deubiquitylation by OTUD5 defines an embryonic pathway intolerant to genomic variation.

PubMed ID: 33523931

DOI: 10.1126/sciadv.abe2116

PubMed ID: 22245969

Title: Phosphorylation-dependent activity of the deubiquitinase DUBA.

PubMed ID: 22245969

DOI: 10.1038/nsmb.2206

Sequence Information:

Length: 571
Mass: 60626
Checksum: F4B2B385B84ABC46
Sequence:

MTILPKKKPP PPDADPANEP PPPGPMPPAP RRGGGVGVGG GGTGVGGGDR DRDSGVVGAR 
PRASPPPQGP LPGPPGALHR WALAVPPGAV AGPRPQQASP PPCGGPGGPG GGPGDALGAA 
AAGVGAAGVV VGVGGAVGVG GCCSGPGHSK RRRQAPGVGA VGGGSPEREE VGAGYNSEDE 
YEAAAARIEA MDPATVEQQE HWFEKALRDK KGFIIKQMKE DGACLFRAVA DQVYGDQDMH 
EVVRKHCMDY LMKNADYFSN YVTEDFTTYI NRKRKNNCHG NHIEMQAMAE MYNRPVEVYQ 
YSTGTSAVEP INTFHGIHQN EDEPIRVSYH RNIHYNSVVN PNKATIGVGL GLPSFKPGFA 
EQSLMKNAIK TSEESWIEQQ MLEDKKRATD WEATNEAIEE QVARESYLQW LRDQEKQARQ 
VRGPSQPRKA SATCSSATAA ASSGLEEWTS RSPRQRSSAS SPEHPELHAE LGMKPPSPGT 
VLALAKPPSP CAPGTSSQFS AGADRATSPL VSLYPALECR ALIQQMSPSA FGLNDWDDDE 
ILASVLAVSQ QEYLDSMKKN KVHRDPPPDK S

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: OTUD5

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of the human X chromosome. PubMed ID: 15772651

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

DUBA: a deubiquitinase that regulates type I interferon production. PubMed ID: 17991829

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. PubMed ID: 23827681

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways. PubMed ID: 33110214

Linkage-specific deubiquitylation by OTUD5 defines an embryonic pathway intolerant to genomic variation. PubMed ID: 33523931

Phosphorylation-dependent activity of the deubiquitinase DUBA. PubMed ID: 22245969