Details for: OTUB1

Gene ID: 55611

Symbol: OTUB1

Ensembl ID: ENSG00000167770

Description: OTU deubiquitinase, ubiquitin aldehyde binding 1

Associated with

Other Information

Genular Protein ID: 666024928

Symbol: OTUB1_HUMAN

Name: Ubiquitin thioesterase OTUB1

UniProtKB Accession Codes:

Q96FW1 Q32Q78 Q96II3 Q9NXQ4 Q9P0B8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 7 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12704427

Title: Otubains: a new family of cysteine proteases in the ubiquitin pathway.

PubMed ID: 12704427

DOI: 10.1038/sj.embor.embor824

PubMed ID: 14661020

Title: Two isoforms of otubain 1 regulate T cell anergy via GRAIL.

PubMed ID: 14661020

DOI: 10.1038/ni1017

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12401499

Title: Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family.

PubMed ID: 12401499

DOI: 10.1016/s1074-5521(02)00248-x

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19383985

Title: OTU Domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) deubiquitinates estrogen receptor (ER) alpha and affects ERalpha transcriptional activity.

PubMed ID: 19383985

DOI: 10.1074/jbc.m109.007484

PubMed ID: 19211026

Title: Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1.

PubMed ID: 19211026

DOI: 10.1016/j.jmb.2008.12.085

PubMed ID: 20725033

Title: Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1.

PubMed ID: 20725033

DOI: 10.1038/nature09297

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23827681

Title: OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.

PubMed ID: 23827681

DOI: 10.1016/j.cell.2013.05.046

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29382726

Title: OTUB1 protein suppresses mTOR complex 1 (mTORC1) activity by deubiquitinating the mTORC1 inhibitor DEPTOR.

PubMed ID: 29382726

DOI: 10.1074/jbc.m117.809533

PubMed ID: 35927303

Title: Phosphorylation of OTUB1 at Tyr 26 stabilizes the mTORC1 component, Raptor.

PubMed ID: 35927303

DOI: 10.1038/s41418-022-01047-3

PubMed ID: 18954305

Title: Structural basis and specificity of human otubain 1-mediated deubiquitination.

PubMed ID: 18954305

DOI: 10.1042/bj20081318

PubMed ID: 22325355

Title: OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function.

PubMed ID: 22325355

DOI: 10.1016/j.molcel.2012.01.011

PubMed ID: 22367539

Title: The mechanism of OTUB1-mediated inhibition of ubiquitination.

PubMed ID: 22367539

DOI: 10.1038/nature10911

Sequence Information:

  • Length: 271
  • Mass: 31284
  • Checksum: 63188EE1DC5FD66F
  • Sequence:
    • MAAEEPQQQK QEPLGSDSEG VNCLAYDEAI MAQQDRIQQE IAVQNPLVSE RLELSVLYKE 
YAEDDNIYQQ KIKDLHKKYS YIRKTRPDGN CFYRAFGFSH LEALLDDSKE LQRFKAVSAK 
SKEDLVSQGF TEFTIEDFHN TFMDLIEQVE KQTSVADLLA SFNDQSTSDY LVVYLRLLTS 
GYLQRESKFF EHFIEGGRTV KEFCQQEVEP MCKESDHIHI IALAQALSVS IQVEYMDRGE 
GGTTNPHIFP EGSEPKVYLL YRPGHYDILY K

Genular Protein ID: 913161019

Symbol: B3KUV5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KUV5

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EC 1 EMBL 2 GO 2 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 5 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 315
  • Mass: 35313
  • Checksum: 1967EB8F1B28868E
  • Sequence:
    • MMKPSWLSRT EFSKRLLCRT LWCQSGWSSR SYTRSMLKMT TSINRRSRTS TKSTRTSARP 
GLTATVSIGL SDSPTWRHCW MTARSCSGEK GGHWAPRQVG VYLLPGRVGC VSSRVSPSFP 
GDGLDSGLAR RGSAVSALAS GLVEEPMLGP PFHPTPRFKA VSAKSKEDLV SQGFTEFTIE 
DFHNTFMDLI EQVEKQTSVA DLLASFNDQS TSDYLVVYLR LLTSGYLQRE SKFFEHFIEG 
GRTVKEFCQQ EVEPMCKESD HIHIIALAQV LSVSIQVEYM DRGEGGTTNP HIFPEGSEPK 
VYLLYRPGHY DILYK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.