TASP1 | ENSG00000089123 | NCBI 55617

Details for: TASP1

Gene ID: 55617

Symbol: TASP1

Ensembl ID: ENSG00000089123

Description: taspase 1

Associated with

Formation of wdr5-containing histone-modifying complexes
(R-HSA-9772755)
Gene expression (transcription)
(R-HSA-74160)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Epigenetic regulation of gene expression
(GO:0040029)
Identical protein binding
(GO:0042802)
Positive regulation of dna-templated transcription
(GO:0045893)
Protein maturation
(GO:0051604)
Proteolysis
(GO:0006508)
Threonine-type endopeptidase activity
(GO:0004298)

Other Information

Proteins

Threonine aspartase 1

Genular Protein ID: 3173489836

Symbol: TASP1_HUMAN

Name: Threonine aspartase 1

UniProtKB Accession Codes:

Q9H6P5 B7Z690 B7Z963 Q5TDU9 Q9BQN0 Q9NQ08 Q9NTS6 Q9NXJ2

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14636557

Title: Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression.

PubMed ID: 14636557

DOI: 10.1016/s0092-8674(03)00816-x

PubMed ID: 31209944

Title: Homozygous loss-of-function variants of TASP1, a gene encoding an activator of the histone methyltransferases KMT2A and KMT2D, cause a syndrome of developmental delay, happy demeanor, distinctive facial features, and congenital anomalies.

PubMed ID: 31209944

DOI: 10.1002/humu.23844

PubMed ID: 16216576

Title: Crystal structure of human Taspase1, a crucial protease regulating the function of MLL.

PubMed ID: 16216576

DOI: 10.1016/j.str.2005.07.006

Sequence Information:

Length: 420
Mass: 44455
Checksum: D0C1020E708B0FCF
Sequence:

MTMEKGMSSG EGLPSRSSQV SAGKITAKEL ETKQSYKEKR GGFVLVHAGA GYHSESKAKE 
YKHVCKRACQ KAIEKLQAGA LATDAVTAAL VELEDSPFTN AGMGSNLNLL GEIECDASIM 
DGKSLNFGAV GALSGIKNPV SVANRLLCEG QKGKLSAGRI PPCFLVGEGA YRWAVDHGIP 
SCPPNIMTTR FSLAAFKRNK RKLELAERVD TDFMQLKKRR QSSEKENDSG TLDTVGAVVV 
DHEGNVAAAV SSGGLALKHP GRVGQAALYG CGCWAENTGA HNPYSTAVST SGCGEHLVRT 
ILARECSHAL QAEDAHQALL ETMQNKFISS PFLASEDGVL GGVIVLRSCR CSAEPDSSQN 
KQTLLVEFLW SHTTESMCVG YMSAQDGKAK THISRLPPGA VAGQSVAIEG GVCRLESPVN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TASP1

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression. PubMed ID: 14636557

Homozygous loss-of-function variants of TASP1, a gene encoding an activator of the histone methyltransferases KMT2A and KMT2D, cause a syndrome of developmental delay, happy demeanor, distinctive facial features, and congenital anomalies. PubMed ID: 31209944