Details for: SLC39A4

Gene ID: 55630

Symbol: SLC39A4

Ensembl ID: ENSG00000147804

Description: solute carrier family 39 member 4

Associated with

Other Information

Genular Protein ID: 2388307555

Symbol: S39A4_HUMAN

Name: Zinc transporter ZIP4

UniProtKB Accession Codes:

Q6P5W5 Q7L5S5 Q9H6T8 Q9NXC4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 2 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 15 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 Rhea 1 SAM 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12068297

Title: Identification of SLC39A4, a gene involved in acrodermatitis enteropathica.

PubMed ID: 12068297

DOI: 10.1038/ng913

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12032886

Title: A novel member of a zinc transporter family is defective in acrodermatitis enteropathica.

PubMed ID: 12032886

DOI: 10.1086/341125

PubMed ID: 14612438

Title: Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane.

PubMed ID: 14612438

DOI: 10.1074/jbc.m310799200

PubMed ID: 12787121

Title: Novel SLC39A4 mutations in acrodermatitis enteropathica.

PubMed ID: 12787121

DOI: 10.1046/j.1523-1747.2003.12243.x

PubMed ID: 17202136

Title: A histidine-rich cluster mediates the ubiquitination and degradation of the human zinc transporter, hZIP4, and protects against zinc cytotoxicity.

PubMed ID: 17202136

DOI: 10.1074/jbc.m610552200

PubMed ID: 22242765

Title: The human ZIP4 transporter has two distinct binding affinities and mediates transport of multiple transition metals.

PubMed ID: 22242765

DOI: 10.1021/bi201553p

PubMed ID: 27321477

Title: Structural insights of ZIP4 extracellular domain critical for optimal zinc transport.

PubMed ID: 27321477

DOI: 10.1038/ncomms11979

PubMed ID: 28875161

Title: Crystal structures of a ZIP zinc transporter reveal a binuclear metal center in the transport pathway.

PubMed ID: 28875161

DOI: 10.1126/sciadv.1700344

PubMed ID: 30874431

Title: Quantifying the Oligomeric State of hZIP4 on the Surface of Cells.

PubMed ID: 30874431

DOI: 10.1021/acs.biochem.9b00131

PubMed ID: 31164399

Title: The histidine-rich loop in the extracellular domain of ZIP4 binds zinc and plays a role in zinc transport.

PubMed ID: 31164399

DOI: 10.1042/bcj20190108

PubMed ID: 31914589

Title: Asymmetric functions of a binuclear metal center within the transport pathway of a human zinc transporter ZIP4.

PubMed ID: 31914589

DOI: 10.1096/fj.201902043r

PubMed ID: 32348750

Title: Molecular Basis of Zinc-Dependent Endocytosis of Human ZIP4 Transceptor.

PubMed ID: 32348750

DOI: 10.1016/j.celrep.2020.107582

PubMed ID: 31979155

Title: Elucidating the H+ Coupled Zn2+ Transport Mechanism of ZIP4; Implications in Acrodermatitis Enteropathica.

PubMed ID: 31979155

DOI: 10.3390/ijms21030734

PubMed ID: 33837739

Title: Zinc transporter mutations linked to acrodermatitis enteropathica disrupt function and cause mistrafficking.

PubMed ID: 33837739

DOI: 10.1016/j.jbc.2021.100269

PubMed ID: 36473915

Title: The transmembrane domains mediate oligomerization of the human ZIP4 transporter in vivo.

PubMed ID: 36473915

DOI: 10.1038/s41598-022-24782-6

Sequence Information:

  • Length: 647
  • Mass: 68408
  • Checksum: AB84735F4BEF434F
  • Sequence:
    • MASLVSLELG LLLAVLVVTA TASPPAGLLS LLTSGQGALD QEALGGLLNT LADRVHCANG 
PCGKCLSVED ALGLGEPEGS GLPPGPVLEA RYVARLSAAA VLYLSNPEGT CEDARAGLWA 
SHADHLLALL ESPKALTPGL SWLLQRMQAR AAGQTPKMAC VDIPQLLEEA VGAGAPGSAG 
GVLAALLDHV RSGSCFHALP SPQYFVDFVF QQHSSEVPMT LAELSALMQR LGVGREAHSD 
HSHRHRGASS RDPVPLISSS NSSSVWDTVC LSARDVMAAY GLSEQAGVTP EAWAQLSPAL 
LQQQLSGACT SQSRPPVQDQ LSQSERYLYG SLATLLICLC AVFGLLLLTC TGCRGVTHYI 
LQTFLSLAVG AVTGDAVLHL TPKVLGLHTH SEEGLSPQPT WRLLAMLAGL YAFFLFENLF 
NLLLPRDPED LEDGPCGHSS HSHGGHSHGV SLQLAPSELR QPKPPHEGSR ADLVAEESPE 
LLNPEPRRLS PELRLLPYMI TLGDAVHNFA DGLAVGAAFA SSWKTGLATS LAVFCHELPH 
ELGDFAALLH AGLSVRQALL LNLASALTAF AGLYVALAVG VSEESEAWIL AVATGLFLYV 
ALCDMLPAML KVRDPRPWLL FLLHNVGLLG GWTVLLLLSL YEDDITF

Genular Protein ID: 1821377883

Symbol: Q9NX22_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NX22

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 GenomeRNAi 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 149
  • Mass: 15867
  • Checksum: 3F07ADD0E9EAF0F0
  • Sequence:
    • MITLGDAVHN FADGLAVGAA FASSWKTGLA TSLAVFCHEL PHELGDFAAL LHAGLSVRQA 
LLLNLASALT AFAGLYVALA VGVSEESEAW ILAVATGLFL YVALCDMLPA MLKVRDPRPW 
LLFLLHNVGL LGGWTVLLLL SLYEDDITF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.