RNF126 | ENSG00000070423 | NCBI 55658

Details for: RNF126

Gene ID: 55658

Symbol: RNF126

Ensembl ID: ENSG00000070423

Description: ring finger protein 126

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Immune system
(R-HSA-168256)
Cytoplasm
(GO:0005737)
Cytoplasm protein quality control by the ubiquitin-proteasome system
(GO:0071629)
Cytosol
(GO:0005829)
Epidermal growth factor receptor binding
(GO:0005154)
Metal ion binding
(GO:0046872)
Negative regulation of epidermal growth factor receptor signaling pathway
(GO:0042059)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein k48-linked ubiquitination
(GO:0070936)
Protein k63-linked ubiquitination
(GO:0070534)
Protein monoubiquitination
(GO:0006513)
Protein ubiquitination
(GO:0016567)
Regulation of cell population proliferation
(GO:0042127)
Retrograde transport, endosome to golgi
(GO:0042147)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
(GO:0043162)
Ubiquitin protein ligase activity
(GO:0061630)

Other Information

Proteins

RN126_HUMAN
A8K0Q1_HUMAN

Genular Protein ID: 3194350838

Symbol: RN126_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BV68 Q9NWX1

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23026136

Title: E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation.

PubMed ID: 23026136

DOI: 10.1158/0008-5472.can-12-0562

PubMed ID: 23418353

Title: The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor.

PubMed ID: 23418353

DOI: 10.1242/jcs.116129

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23277564

Title: Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase.

PubMed ID: 23277564

DOI: 10.1073/pnas.1214538110

PubMed ID: 24275455

Title: The ubiquitin ligase RNF126 regulates the retrograde sorting of the cation-independent mannose 6-phosphate receptor.

PubMed ID: 24275455

DOI: 10.1016/j.yexcr.2013.11.013

PubMed ID: 24981174

Title: Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6.

PubMed ID: 24981174

DOI: 10.1016/j.molcel.2014.05.025

PubMed ID: 29042515

Title: Structural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC35.

PubMed ID: 29042515

DOI: 10.1073/pnas.1702940114

PubMed ID: 27193484

Title: Structural and functional insights into the E3 ligase, RNF126.

PubMed ID: 27193484

DOI: 10.1038/srep26433

Sequence Information:

Length: 311
Mass: 33861
Checksum: 0C748E78E6719C3E
Sequence:

MAEASPHPGR YFCHCCSVEI VPRLPDYICP RCESGFIEEL PEETRSTENG SAPSTAPTDQ 
SRPPLEHVDQ HLFTLPQGYG QFAFGIFDDS FEIPTFPPGA QADDGRDPES RRERDHPSRH 
RYGARQPRAR LTTRRATGRH EGVPTLEGII QQLVNGIITP ATIPSLGPWG VLHSNPMDYA 
WGANGLDAII TQLLNQFENT GPPPADKEKI QALPTVPVTE EHVGSGLECP VCKDDYALGE 
RVRQLPCNHL FHDGCIVPWL EQHDSCPVCR KSLTGQNTAT NPPGLTGVSF SSSSSSSSSS 
SPSNENATSN S

Genular Protein ID: 259830408

Symbol: A8K0Q1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K0Q1

Database IDs:

Sequence Information:

Length: 311
Mass: 33909
Checksum: 2B60B63B16DDD021
Sequence:

MAEASPHPGR YFCHCCSVEI VPRLPDYICP RCESDFIEEL PEETRSTENG SAPSTAPTDQ 
SRPPLEHVDQ HLFTLPQGYG QFAFGIFDDS FEIPTFPPGA QADDGRDPES RRERDHPSRH 
RYGARQPRAR LTTRRATGRH EGVPTLEGII QQLVNGIITP ATIPSLGPWG VLHSNPMDYA 
WGANGLDAII TQLLNQFENT GPPSADKEKI QALPTVPVTE EHVGSGLECP VCKDDYALGE 
RVRQLPCNHL FHDGCIVPWL EQHDSCPVCR KSLTGQNTAT NPPGLTGVSF SSSSSSSSSS 
SPSNENATSN S

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RNF126

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation. PubMed ID: 23026136

The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor. PubMed ID: 23418353

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase. PubMed ID: 23277564

The ubiquitin ligase RNF126 regulates the retrograde sorting of the cation-independent mannose 6-phosphate receptor. PubMed ID: 24275455

Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6. PubMed ID: 24981174

Structural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC35. PubMed ID: 29042515

Structural and functional insights into the E3 ligase, RNF126. PubMed ID: 27193484