PACS1 | ENSG00000175115 | NCBI 55690

Details for: PACS1

Gene ID: 55690

Symbol: PACS1

Ensembl ID: ENSG00000175115

Description: phosphofurin acidic cluster sorting protein 1

Associated with

Disease
(R-HSA-1643685)
Hiv infection
(R-HSA-162906)
Host interactions of hiv factors
(R-HSA-162909)
Infectious disease
(R-HSA-5663205)
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
(R-HSA-164938)
Nef mediated downregulation of mhc class i complex cell surface expression
(R-HSA-164940)
The role of nef in hiv-1 replication and disease pathogenesis
(R-HSA-164952)
Viral infection pathways
(R-HSA-9824446)
Copi-coated vesicle
(GO:0030137)
Cytosol
(GO:0005829)
Golgi apparatus
(GO:0005794)
Lymphocyte homeostasis
(GO:0002260)
Protein binding
(GO:0005515)
Protein localization to golgi apparatus
(GO:0034067)
Protein localization to plasma membrane
(GO:0072659)
Transmembrane transporter binding
(GO:0044325)

Other Information

Proteins

Phosphofurin acidic cluster sorting protein 1

Genular Protein ID: 641212176

Symbol: PACS1_HUMAN

Name: Phosphofurin acidic cluster sorting protein 1

UniProtKB Accession Codes:

Q6VY07 Q6PJY6 Q6PKB6 Q7Z590 Q7Z5W4 Q8N8K6 Q96MW0 Q9NW92 Q9ULP5

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10574461

Title: Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.

PubMed ID: 10574461

DOI: 10.1093/dnares/6.5.329

PubMed ID: 11331585

Title: PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic.

PubMed ID: 11331585

DOI: 10.1093/emboj/20.9.2191

PubMed ID: 10707087

Title: HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes.

PubMed ID: 10707087

DOI: 10.1038/35004038

PubMed ID: 12526811

Title: HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway.

PubMed ID: 12526811

DOI: 10.1016/s0092-8674(02)01162-5

PubMed ID: 15692563

Title: Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation.

PubMed ID: 15692563

DOI: 10.1038/sj.emboj.7600566

PubMed ID: 16308564

Title: Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia.

PubMed ID: 16308564

DOI: 10.1038/sj.emboj.7600885

PubMed ID: 17855360

Title: SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1.

PubMed ID: 17855360

DOI: 10.1074/jbc.m705073200

PubMed ID: 17646382

Title: Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA.

PubMed ID: 17646382

DOI: 10.1128/mcb.00815-07

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18296443

Title: HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice.

PubMed ID: 18296443

DOI: 10.1074/jbc.m707572200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22740416

Title: Characterization and intracellular trafficking of Epstein-Barr virus BBLF1, a protein involved in virion maturation.

PubMed ID: 22740416

DOI: 10.1128/jvi.01126-12

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 34642815

Title: WDR37 syndrome: identification of a distinct new cluster of disease-associated variants and functional analyses of mutant proteins.

PubMed ID: 34642815

DOI: 10.1007/s00439-021-02384-y

PubMed ID: 23159249

Title: Recurrent de novo mutations in PACS1 cause defective cranial-neural-crest migration and define a recognizable intellectual-disability syndrome.

PubMed ID: 23159249

DOI: 10.1016/j.ajhg.2012.10.013

Sequence Information:

Length: 963
Mass: 104898
Checksum: 0F6B2CA24F7CD567
Sequence:

MAERGGAGGG PGGAGGGSGQ RGSGVAQSPQ QPPPQQQQQQ PPQQPTPPKL AQATSSSSST 
SAAAASSSSS STSTSMAVAV ASGSAPPGGP GPGRTPAPVQ MNLYATWEVD RSSSSCVPRL 
FSLTLKKLVM LKEMDKDLNS VVIAVKLQGS KRILRSNEIV LPASGLVETE LQLTFSLQYP 
HFLKRDANKL QIMLQRRKRY KNRTILGYKT LAVGLINMAE VMQHPNEGAL VLGLHSNVKD 
VSVPVAEIKI YSLSSQPIDH EGIKSKLSDR SPDIDNYSEE EEESFSSEQE GSDDPLHGQD 
LFYEDEDLRK VKKTRRKLTS TSAITRQPNI KQKFVALLKR FKVSDEVGFG LEHVSREQIR 
EVEEDLDELY DSLEMYNPSD SGPEMEETES ILSTPKPKLK PFFEGMSQSS SQTEIGSLNS 
KGSLGKDTTS PMELAALEKI KSTWIKNQDD SLTETDTLEI TDQDMFGDAS TSLVVPEKVK 
TPMKSSKTDL QGSASPSKVE GVHTPRQKRS TPLKERQLSK PLSERTNSSD SERSPDLGHS 
TQIPRKVVYD QLNQILVSDA ALPENVILVN TTDWQGQYVA ELLQDQRKPV VCTCSTVEVQ 
AVLSALLTRI QRYCNCNSSM PRPVKVAAVG GQSYLSSILR FFVKSLANKT SDWLGYMRFL 
IIPLGSHPVA KYLGSVDSKY SSSFLDSGWR DLFSRSEPPV SEQLDVAGRV MQYVNGAATT 
HQLPVAEAML TCRHKFPDED SYQKFIPFIG VVKVGLVEDS PSTAGDGDDS PVVSLTVPST 
SPPSSSGLSR DATATPPSSP SMSSALAIVG SPNSPYGDVI GLQVDYWLGH PGERRREGDK 
RDASSKNTLK SVFRSVQVSR LPHSGEAQLS GTMAMTVVTK EKNKKVPTIF LSKKPREKEV 
DSKSQVIEGI SRLICSAKQQ QTMLRVSIDG VEWSDIKFFQ LAAQWPTHVK HFPVGLFSGS 
KAT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PACS1

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. PubMed ID: 10574461

PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic. PubMed ID: 11331585

HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes. PubMed ID: 10707087

HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway. PubMed ID: 12526811

Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. PubMed ID: 15692563

Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia. PubMed ID: 16308564

SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1. PubMed ID: 17855360

Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA. PubMed ID: 17646382

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice. PubMed ID: 18296443

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Characterization and intracellular trafficking of Epstein-Barr virus BBLF1, a protein involved in virion maturation. PubMed ID: 22740416

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

WDR37 syndrome: identification of a distinct new cluster of disease-associated variants and functional analyses of mutant proteins. PubMed ID: 34642815

Recurrent de novo mutations in PACS1 cause defective cranial-neural-crest migration and define a recognizable intellectual-disability syndrome. PubMed ID: 23159249