Details for: CCDC88A
Associated with
Other Information
Genular Protein ID: 1371372229
Symbol: GRDN_HUMAN
Name: Girdin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16139227
Title: Akt/PKB regulates actin organization and cell motility via Girdin/APE.
PubMed ID: 16139227
PubMed ID: 15882442
Title: A novel hook-related protein family and the characterization of hook-related protein 1.
PubMed ID: 15882442
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15749703
Title: Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles.
PubMed ID: 15749703
PubMed ID: 17185515
Title: Girdin, a novel actin-binding protein, and its family of proteins possess versatile functions in the Akt and Wnt signaling pathways.
PubMed ID: 17185515
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19211784
Title: GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling.
PubMed ID: 19211784
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20462955
Title: A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate.
PubMed ID: 20462955
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21954290
Title: Tyrosine phosphorylation of the Galpha-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration.
PubMed ID: 21954290
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23509302
Title: Protein kinase C-theta (PKCtheta) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin.
PubMed ID: 23509302
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25187647
Title: Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.
PubMed ID: 25187647
PubMed ID: 27864364
Title: Membrane recruitment of the non-receptor protein GIV/Girdin (Galpha-interacting, Vesicle-associated Protein/Girdin) is sufficient for activating heterotrimeric G protein signaling.
PubMed ID: 27864364
PubMed ID: 27621449
Title: GIV/Girdin activates Galphai and inhibits Galphas via the same motif.
PubMed ID: 27621449
PubMed ID: 26917597
Title: CCDC88A mutations cause PEHO-like syndrome in humans and mouse.
PubMed ID: 26917597
DOI: 10.1093/brain/aww014
PubMed ID: 27623382
Title: A Conserved role for girdin in basal body positioning and ciliogenesis.
PubMed ID: 27623382
PubMed ID: 30194280
Title: A biochemical and genetic discovery pipeline identifies PLCdelta4b as a nonreceptor activator of heterotrimeric G-proteins.
PubMed ID: 30194280
PubMed ID: 31363053
Title: Structural basis for GPCR-independent activation of heterotrimeric Gi proteins.
PubMed ID: 31363053
PubMed ID: 31570568
Sequence Information:
- Length: 1871
- Mass: 216042
- Checksum: 9DD2E06F2A235AA5
- Sequence:
MENEIFTPLL EQFMTSPLVT WVKTFGPLAA GNGTNLDEYV ALVDGVFLNQ VMLQINPKLE SQRVNKKVNN DASLRMHNLS ILVRQIKFYY QETLQQLIMM SLPNVLIIGK NPFSEQGTEE VKKLLLLLLG CAVQCQKKEE FIERIQGLDF DTKAAVAAHI QEVTHNQENV FDLQWMEVTD MSQEDIEPLL KNMALHLKRL IDERDEHSET IIELSEERDG LHFLPHASSS AQSPCGSPGM KRTESRQHLS VELADAKAKI RRLRQELEEK TEQLLDCKQE LEQMEIELKR LQQENMNLLS DARSARMYRD ELDALREKAV RVDKLESEVS RYKERLHDIE FYKARVEELK EDNQVLLETK TMLEDQLEGT RARSDKLHEL EKENLQLKAK LHDMEMERDM DRKKIEELME ENMTLEMAQK QSMDESLHLG WELEQISRTS ELSEAPQKSL GHEVNELTSS RLLKLEMENQ SLTKTVEELR TTVDSVEGNA SKILKMEKEN QRLSKKVEIL ENEIVQEKQS LQNCQNLSKD LMKEKAQLEK TIETLRENSE RQIKILEQEN EHLNQTVSSL RQRSQISAEA RVKDIEKENK ILHESIKETS SKLSKIEFEK RQIKKELEHY KEKGERAEEL ENELHHLEKE NELLQKKITN LKITCEKIEA LEQENSELER ENRKLKKTLD SFKNLTFQLE SLEKENSQLD EENLELRRNV ESLKCASMKM AQLQLENKEL ESEKEQLKKG LELLKASFKK TERLEVSYQG LDIENQRLQK TLENSNKKIQ QLESELQDLE MENQTLQKNL EELKISSKRL EQLEKENKSL EQETSQLEKD KKQLEKENKR LRQQAEIKDT TLEENNVKIG NLEKENKTLS KEIGIYKESC VRLKELEKEN KELVKRATID IKTLVTLRED LVSEKLKTQQ MNNDLEKLTH ELEKIGLNKE RLLHDEQSTD DSRYKLLESK LESTLKKSLE IKEEKIAALE ARLEESTNYN QQLRQELKTV KKNYEALKQR QDEERMVQSS PPISGEDNKW ERESQETTRE LLKVKDRLIE VERNNATLQA EKQALKTQLK QLETQNNNLQ AQILALQRQT VSLQEQNTTL QTQNAKLQVE NSTLNSQSTS LMNQNAQLLI QQSSLENENE SVIKEREDLK SLYDSLIKDH EKLELLHERQ ASEYESLISK HGTLKSAHKN LEVEHRDLED RYNQLLKQKG QLEDLEKMLK VEQEKMLLEN KNHETVAAEY KKLCGENDRL NHTYSQLLKE TEVLQTDHKN LKSLLNNSKL EQTRLEAEFS KLKEQYQQLD ITSTKLNNQC ELLSQLKGNL EEENRHLLDQ IQTLMLQNRT LLEQNMESKD LFHVEQRQYI DKLNELRRQK EKLEEKIMDQ YKFYDPSPPR RRGNWITLKM RKLIKSKKDI NRERQKSLTL TPTRSDSSEG FLQLPHQDSQ DSSSVGSNSL EDGQTLGTKK SSMVALKRLP FLRNRPKDKD KMKACYRRSM SMNDLVQSMV LAGQWTGSTE NLEVPDDIST GKRRKELGAM AFSTTAINFS TVNSSAGFRS KQLVNNKDTT SFEDISPQGV SDDSSTGSRV HASRPASLDS GRTSTSNSNN NASLHEVKAG AVNNQSRPQS HSSGEFSLLH DHEAWSSSGS SPIQYLKRQT RSSPVLQHKI SETLESRHHK IKTGSPGSEV VTLQQFLEES NKLTSVQIKS SSQENLLDEV MKSLSVSSDF LGKDKPVSCG LARSVSGKTP GDFYDRRTTK PEFLRPGPRK TEDTYFISSA GKPTPGTQGK IKLVKESSLS RQSKDSNPYA TLPRASSVIS TAEGTTRRTS IHDFLTKDSR LPISVDSPPA AADSNTTAAS NVDKVQESRN SKSRSREQQS S
Genular Protein ID: 2574791322
Symbol: O14997_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 709
- Mass: 83454
- Checksum: E55CD5E7C740DA7C
- Sequence:
MHNLSILVRQ IKFYYQETLQ QLIMMSLPNV LIIGKNPFSE QGTEEVKKLL LLLLGCAVQC QKKEEFIERI QGLDFDTKAA VAAHIQEVTH NQENVFDLQW MEVTDMSQED IEPLLKNMAL HLKRLIDERD EHSETIIELS EERDGLHFLP HASSSAQSPC GSPGMKRTES RQHLSVELAD AKAKIRRLRQ ELEEKTEQLL DCKQELEQME IELKRLQQEN MNLLSDARSA RMYRDELDAL REKAVRVDKL ESEVSRYKER LHDIEFYKAR VEELKEDNQV LLETKTMLED QLEGTRARSD KLHELEKENL QLKAKLHDME MERDMDRKKI EELMEENMTL EMAQKQSMDE SLHLGWELEQ ISRTSELSEA PQKSLGHEVN ELTSSRLLKL EMENQSLTKT VEELRTTVDS VEGNASKILK MEKENQRLSK KVEILENEIV QEKQSLQNCQ NLSKDLMKEK AQLEKTIETL RENSERQIKI LEQENEHLNQ TVSSLRQRSQ ISAEARVKDI EKENKILHES IKETSSKLSK IEFEKRQIKK ELEHYKEKGE RAEELENELH HLEKENELLQ KKITNLKITC EKIEALEQEN SELERENRKL KKTLDSFKNL TFQLESLEKE NSQLDEENLE LRRNVESLKC ASMKMAQLQL ENKELESEKE QLKKGLELLK ASFKKTERLE VSYQGLDIEN QRLQKTLENS NKKKKRPRI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.