PRKAR1A | ENSG00000108946 | NCBI 5573

Details for: PRKAR1A

Gene ID: 5573

Symbol: PRKAR1A

Ensembl ID: ENSG00000108946

Description: protein kinase cAMP-dependent type I regulatory subunit alpha

Associated with

Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Adora2b mediated anti-inflammatory cytokines production
(R-HSA-9660821)
Alk mutants bind tkis
(R-HSA-9700645)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Aquaporin-mediated transport
(R-HSA-445717)
Ca-dependent events
(R-HSA-111996)
Calmodulin induced events
(R-HSA-111933)
Cam pathway
(R-HSA-111997)
Creb1 phosphorylation through the activation of adenylate cyclase
(R-HSA-442720)
Dag and ip3 signaling
(R-HSA-1489509)
Darpp-32 events
(R-HSA-180024)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
G-protein mediated events
(R-HSA-112040)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (s) signalling events
(R-HSA-418555)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-HSA-381676)
Glucagon signaling in metabolic regulation
(R-HSA-163359)
Gpcr downstream signalling
(R-HSA-388396)
Gper1 signaling
(R-HSA-9634597)
Hedgehog 'off' state
(R-HSA-5610787)
Hemostasis
(R-HSA-109582)
Infectious disease
(R-HSA-5663205)
Integration of energy metabolism
(R-HSA-163685)
Intracellular signaling by second messengers
(R-HSA-9006925)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Metabolism
(R-HSA-1430728)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Opioid signalling
(R-HSA-111885)
Parasitic infection pathways
(R-HSA-9824443)
Pka-mediated phosphorylation of creb
(R-HSA-111931)
Pka activation
(R-HSA-163615)
Pka activation in glucagon signalling
(R-HSA-164378)
Plc beta mediated events
(R-HSA-112043)
Post nmda receptor activation events
(R-HSA-438064)
Regulation of insulin secretion
(R-HSA-422356)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by gpcr
(R-HSA-372790)
Signaling by hedgehog
(R-HSA-5358351)
Signal transduction
(R-HSA-162582)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Vasopressin regulates renal water homeostasis via aquaporins
(R-HSA-432040)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Axoneme
(GO:0005930)
Camp-dependent protein kinase complex
(GO:0005952)
Camp-dependent protein kinase inhibitor activity
(GO:0004862)
Camp-dependent protein kinase regulator activity
(GO:0008603)
Camp binding
(GO:0030552)
Cardiac muscle cell proliferation
(GO:0060038)
Cellular response to glucagon stimulus
(GO:0071377)
Centrosome
(GO:0005813)
Ciliary base
(GO:0097546)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Glutamatergic synapse
(GO:0098978)
Immunological synapse
(GO:0001772)
Intracellular signal transduction
(GO:0035556)
Membrane
(GO:0016020)
Mesoderm formation
(GO:0001707)
Multivesicular body
(GO:0005771)
Negative regulation of activated t cell proliferation
(GO:0046007)
Negative regulation of camp-dependent protein kinase activity
(GO:2000480)
Negative regulation of gene expression
(GO:0010629)
Neuromuscular junction
(GO:0031594)
Nucleotide-activated protein kinase complex
(GO:0031588)
Plasma membrane raft
(GO:0044853)
Positive regulation of insulin secretion
(GO:0032024)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase a catalytic subunit binding
(GO:0034236)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Sarcomere organization
(GO:0045214)
Sperm connecting piece
(GO:0097224)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

cAMP-dependent protein kinase type I-alpha regulatory subunit

Genular Protein ID: 110432363

Symbol: KAP0_HUMAN

Name: cAMP-dependent protein kinase type I-alpha regulatory subunit

UniProtKB Accession Codes:

P10644 K7ER48 Q567S7

Database IDs:

Citations:

PubMed ID: 3426618

Title: Molecular cloning, cDNA structure and deduced amino acid sequence for a type I regulatory subunit of cAMP-dependent protein kinase from human testis.

PubMed ID: 3426618

DOI: 10.1016/0006-291x(87)90499-2

PubMed ID: 2310396

Title: The two mRNA forms for the type I alpha regulatory subunit of cAMP-dependent protein kinase from human testis are due to the use of different polyadenylation site signals.

PubMed ID: 2310396

DOI: 10.1016/0006-291x(90)91768-n

PubMed ID: 1889088

Title: Subtractive hybridization cloning of a tissue-specific extinguisher: TSE1 encodes a regulatory subunit of protein kinase A.

PubMed ID: 1889088

DOI: 10.1016/0092-8674(91)90433-y

PubMed ID: 8977401

Title: The human gene for the regulatory subunit RI alpha of cyclic adenosine 3', 5'-monophosphate-dependent protein kinase: two distinct promoters provide differential regulation of alternately spliced messenger ribonucleic acids.

PubMed ID: 8977401

DOI: 10.1210/endo.138.1.4864

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 12213893

Title: Mutations of the PRKAR1A gene in Cushing's syndrome due to sporadic primary pigmented nodular adrenocortical disease.

PubMed ID: 12213893

DOI: 10.1210/jc.2002-020592

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15655353

Title: The second subunit of the replication factor C complex (RFC40) and the regulatory subunit (RIalpha) of protein kinase A form a protein complex promoting cell survival.

PubMed ID: 15655353

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16491121

Title: Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation.

PubMed ID: 16491121

DOI: 10.1038/sj.onc.1209436

PubMed ID: 16387847

Title: PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells.

PubMed ID: 16387847

DOI: 10.1073/pnas.0509969103

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20215566

Title: Activity of retinoic acid receptor-alpha is directly regulated at its protein kinase A sites in response to follicle-stimulating hormone signaling.

PubMed ID: 20215566

DOI: 10.1210/en.2009-1338

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21651393

Title: Recurrent PRKAR1A mutation in acrodysostosis with hormone resistance.

PubMed ID: 21651393

DOI: 10.1056/nejmoa1012717

PubMed ID: 21423175

Title: Control of PKA stability and signalling by the RING ligase praja2.

PubMed ID: 21423175

DOI: 10.1038/ncb2209

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22785148

Title: An unusual presentation of Carney complex with diffuse primary pigmented nodular adrenocortical disease on one adrenal gland and a nonpigmented adrenocortical adenoma and focal primary pigmented nodular adrenocortical disease on the other.

PubMed ID: 22785148

DOI: 10.1507/endocrj.ej12-0040

PubMed ID: 23115245

Title: A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane.

PubMed ID: 23115245

DOI: 10.1074/jbc.m112.395970

PubMed ID: 23323113

Title: Novel Mutation in PRKAR1A in Carney Complex.

PubMed ID: 23323113

DOI: 10.4132/koreanjpathol.2012.46.6.595

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 33058759

Title: Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome.

PubMed ID: 33058759

DOI: 10.1016/j.ajhg.2020.09.005

PubMed ID: 15371594

Title: Comparative PRKAR1A genotype-phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice.

PubMed ID: 15371594

DOI: 10.1073/pnas.0405535101

PubMed ID: 18241045

Title: In vitro functional studies of naturally occurring pathogenic PRKAR1A mutations that are not subject to nonsense mRNA decay.

PubMed ID: 18241045

DOI: 10.1002/humu.20688

PubMed ID: 22464250

Title: Exome sequencing identifies PDE4D mutations as another cause of acrodysostosis.

PubMed ID: 22464250

DOI: 10.1016/j.ajhg.2012.03.003

PubMed ID: 22464252

Title: Exome sequencing identifies PDE4D mutations in acrodysostosis.

PubMed ID: 22464252

DOI: 10.1016/j.ajhg.2012.03.004

PubMed ID: 23043190

Title: PRKAR1A and PDE4D mutations cause acrodysostosis but two distinct syndromes with or without GPCR-signaling hormone resistance.

PubMed ID: 23043190

DOI: 10.1210/jc.2012-2326

PubMed ID: 22723333

Title: PRKAR1A mutation affecting cAMP-mediated G protein-coupled receptor signaling in a patient with acrodysostosis and hormone resistance.

PubMed ID: 22723333

DOI: 10.1210/jc.2012-1369

PubMed ID: 23425300

Title: Novel mutations of the PRKAR1A gene in patients with acrodysostosis.

PubMed ID: 23425300

DOI: 10.1111/cge.12106

PubMed ID: 26405036

Title: Functional characterization of PRKAR1A mutations reveals a unique molecular mechanism causing acrodysostosis but multiple mechanisms causing carney complex.

PubMed ID: 26405036

DOI: 10.1074/jbc.m115.656553

Sequence Information:

Length: 381
Mass: 42982
Checksum: 2D04F08CE8857A6D
Sequence:

MESGSTAASE EARSLRECEL YVQKHNIQAL LKDSIVQLCT ARPERPMAFL REYFERLEKE 
EAKQIQNLQK AGTRTDSRED EISPPPPNPV VKGRRRRGAI SAEVYTEEDA ASYVRKVIPK 
DYKTMAALAK AIEKNVLFSH LDDNERSDIF DAMFSVSFIA GETVIQQGDE GDNFYVIDQG 
ETDVYVNNEW ATSVGEGGSF GELALIYGTP RAATVKAKTN VKLWGIDRDS YRRILMGSTL 
RKRKMYEEFL SKVSILESLD KWERLTVADA LEPVQFEDGQ KIVVQGEPGD EFFIILEGSA 
AVLQRRSENE EFVEVGRLGP SDYFGEIALL MNRPRAATVV ARGPLKCVKL DRPRFERVLG 
PCSDILKRNI QQYNSFVSLS V

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PRKAR1A

Associated with

Other Information

Molecular cloning, cDNA structure and deduced amino acid sequence for a type I regulatory subunit of cAMP-dependent protein kinase from human testis. PubMed ID: 3426618

The two mRNA forms for the type I alpha regulatory subunit of cAMP-dependent protein kinase from human testis are due to the use of different polyadenylation site signals. PubMed ID: 2310396

Subtractive hybridization cloning of a tissue-specific extinguisher: TSE1 encodes a regulatory subunit of protein kinase A. PubMed ID: 1889088

The human gene for the regulatory subunit RI alpha of cyclic adenosine 3', 5'-monophosphate-dependent protein kinase: two distinct promoters provide differential regulation of alternately spliced messenger ribonucleic acids. PubMed ID: 8977401

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

Mutations of the PRKAR1A gene in Cushing's syndrome due to sporadic primary pigmented nodular adrenocortical disease. PubMed ID: 12213893

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

The second subunit of the replication factor C complex (RFC40) and the regulatory subunit (RIalpha) of protein kinase A form a protein complex promoting cell survival. PubMed ID: 15655353

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation. PubMed ID: 16491121

PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells. PubMed ID: 16387847

Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment. PubMed ID: 19367720

Phosphoproteome of resting human platelets. PubMed ID: 18088087

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. PubMed ID: 18318008

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Activity of retinoic acid receptor-alpha is directly regulated at its protein kinase A sites in response to follicle-stimulating hormone signaling. PubMed ID: 20215566

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Recurrent PRKAR1A mutation in acrodysostosis with hormone resistance. PubMed ID: 21651393

Control of PKA stability and signalling by the RING ligase praja2. PubMed ID: 21423175

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

An unusual presentation of Carney complex with diffuse primary pigmented nodular adrenocortical disease on one adrenal gland and a nonpigmented adrenocortical adenoma and focal primary pigmented nodular adrenocortical disease on the other. PubMed ID: 22785148

A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane. PubMed ID: 23115245

Novel Mutation in PRKAR1A in Carney Complex. PubMed ID: 23323113

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome. PubMed ID: 33058759

Comparative PRKAR1A genotype-phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice. PubMed ID: 15371594

In vitro functional studies of naturally occurring pathogenic PRKAR1A mutations that are not subject to nonsense mRNA decay. PubMed ID: 18241045

Exome sequencing identifies PDE4D mutations as another cause of acrodysostosis. PubMed ID: 22464250

Exome sequencing identifies PDE4D mutations in acrodysostosis. PubMed ID: 22464252

PRKAR1A and PDE4D mutations cause acrodysostosis but two distinct syndromes with or without GPCR-signaling hormone resistance. PubMed ID: 23043190

PRKAR1A mutation affecting cAMP-mediated G protein-coupled receptor signaling in a patient with acrodysostosis and hormone resistance. PubMed ID: 22723333

Novel mutations of the PRKAR1A gene in patients with acrodysostosis. PubMed ID: 23425300

Functional characterization of PRKAR1A mutations reveals a unique molecular mechanism causing acrodysostosis but multiple mechanisms causing carney complex. PubMed ID: 26405036