Details for: HHAT

Gene ID: 55733

Symbol: HHAT

Ensembl ID: ENSG00000054392

Description: hedgehog acyltransferase

Associated with

Other Information

Genular Protein ID: 376857147

Symbol: HHAT_HUMAN

Name: Protein-cysteine N-palmitoyltransferase HHAT

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11160356

Title: Isolation of a new melanoma antigen, MART-2, containing a mutated epitope recognized by autologous tumor-infiltrating T lymphocytes.

PubMed ID: 11160356

DOI: 10.4049/jimmunol.166.4.2871

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11486055

Title: Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal.

PubMed ID: 11486055

DOI: 10.1126/science.1064437

PubMed ID: 18534984

Title: Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog.

PubMed ID: 18534984

DOI: 10.1074/jbc.m803901200

PubMed ID: 25488661

Title: Membrane topology of hedgehog acyltransferase.

PubMed ID: 25488661

DOI: 10.1074/jbc.m114.625764

PubMed ID: 25505265

Title: Topological analysis of Hedgehog acyltransferase, a multipalmitoylated transmembrane protein.

PubMed ID: 25505265

DOI: 10.1074/jbc.m114.614578

PubMed ID: 31875564

Title: Hedgehog Acyltransferase Promotes Uptake of Palmitoyl-CoA across the Endoplasmic Reticulum Membrane.

PubMed ID: 31875564

DOI: 10.1016/j.celrep.2019.11.110

PubMed ID: 24784881

Title: Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signaling.

PubMed ID: 24784881

DOI: 10.1371/journal.pgen.1004340

PubMed ID: 30912300

Title: Biallelic novel missense HHAT variant causes syndromic microcephaly and cerebellar-vermis hypoplasia.

PubMed ID: 30912300

DOI: 10.1002/ajmg.a.61133

Sequence Information:

  • Length: 493
  • Mass: 57313
  • Checksum: 5E962E2A61F2DE15
  • Sequence:
  • MLPRWELALY LLASLGFHFY SFYEVYKVSR EHEEELDQEF ELETDTLFGG LKKDATDFEW 
    SFWMEWGKQW LVWLLLGHMV VSQMATLLAR KHRPWILMLY GMWACWCVLG TPGVAMVLLH 
    TTISFCVAQF RSQLLTWLCS LLLLSTLRLQ GVEEVKRRWY KTENEYYLLQ FTLTVRCLYY 
    TSFSLELCWQ QLPAASTSYS FPWMLAYVFY YPVLHNGPIL SFSEFIKQMQ QQEHDSLKAS 
    LCVLALGLGR LLCWWWLAEL MAHLMYMHAI YSSIPLLETV SCWTLGGLAL AQVLFFYVKY 
    LVLFGVPALL MRLDGLTPPA LPRCVSTMFS FTGMWRYFDV GLHNFLIRYV YIPVGGSQHG 
    LLGTLFSTAM TFAFVSYWHG GYDYLWCWAA LNWLGVTVEN GVRRLVETPC IQDSLARYFS 
    PQARRRFHAA LASCSTSMLI LSNLVFLGGN EVGKTYWNRI FIQGWPWVTL SVLGFLYCYS 
    HVGIAWAQTY ATD

Genular Protein ID: 1668094498

Symbol: B7Z5N1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 430
  • Mass: 49611
  • Checksum: 64CA9B64F3E1ED46
  • Sequence:
  • MEWGKQWLVW LLLGHMVVSQ MATLLARKHR PWILMLYGMW ACWCVLGTPG VAMVLLHTTI 
    SFCVAQFRSQ LLTWLCSLPL LSTLRLQGVE EVKRRWYKTE NEYYLLQFTL TVRCLYYTSF 
    SLELCWQQLP AASTSYSFPW MLAYVFYYPV LHNGPILSFS EFIEQMQQQE HDSLKASLCV 
    LALGLGRLLC WWWLAELMAH LMYMHAIYSS IPLLETVSCW TLGGLALAQV LFFYVKYLVL 
    FGVPALLMRL DGLTPPALPR CVSTMFSFTG MWRYFDVGLH NFLIRYVYIP VGGSQHGLLG 
    TLFSTAMTFA FVSYWHGGYD YLWCWAALNW LGVTVENGVR RLVETPCIQD SLARYFSPQA 
    RRRFHAALAS CSTSMLILSN LVFLGGNEVG KTYWNRIFIQ GWPWVTLSVL GFLYCYSHVG 
    IAWAQTYATD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.