Details for: VPS35
Associated with
Other Information
Genular Protein ID: 3381680665
Symbol: VPS35_HUMAN
Name: Vacuolar protein sorting-associated protein 35
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11062004
Title: Human homologues of yeast vacuolar protein sorting 29 and 35.
PubMed ID: 11062004
PubMed ID: 11112353
Title: Cloning and characterization of human VPS35 and mouse Vps35 and mapping of VPS35 to human chromosome 16q13-q21.
PubMed ID: 11112353
PubMed ID: 11102511
Title: Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes.
PubMed ID: 11102511
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 11230166
Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
PubMed ID: 11230166
DOI: 10.1101/gr.gr1547r
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15078903
Title: Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor.
PubMed ID: 15078903
PubMed ID: 15247922
Title: The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor.
PubMed ID: 15247922
DOI: 10.1038/ncb1153
PubMed ID: 17868075
Title: EHD1 interacts with retromer to stabilize SNX1 tubules and facilitate endosome-to-Golgi retrieval.
PubMed ID: 17868075
PubMed ID: 19531583
Title: Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5.
PubMed ID: 19531583
DOI: 10.1242/jcs.048686
PubMed ID: 19553991
Title: GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer.
PubMed ID: 19553991
DOI: 10.1038/nature08109
PubMed ID: 20923837
Title: The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics.
PubMed ID: 20923837
DOI: 10.1242/jcs.071472
PubMed ID: 20164305
Title: Retromer-mediated direct sorting is required for proper endosomal recycling of the mammalian iron transporter DMT1.
PubMed ID: 20164305
DOI: 10.1242/jcs.060574
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21725319
Title: A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion.
PubMed ID: 21725319
DOI: 10.1038/ncb2281
PubMed ID: 22070227
Title: Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35.
PubMed ID: 22070227
DOI: 10.1042/bj20111761
PubMed ID: 22513087
Title: Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer.
PubMed ID: 22513087
PubMed ID: 23331060
Title: Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer.
PubMed ID: 23331060
PubMed ID: 23452853
Title: Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination.
PubMed ID: 23452853
PubMed ID: 23563491
Title: A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport.
PubMed ID: 23563491
DOI: 10.1038/ncb2721
PubMed ID: 23395371
Title: RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk.
PubMed ID: 23395371
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24344282
Title: A mechanism for retromer endosomal coat complex assembly with cargo.
PubMed ID: 24344282
PubMed ID: 24980502
Title: Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation.
PubMed ID: 24980502
PubMed ID: 24819384
Title: Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy.
PubMed ID: 24819384
DOI: 10.1038/ncomms4828
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 25693203
Title: Direct binding of retromer to human papillomavirus type 16 minor capsid protein L2 mediates endosome exit during viral infection.
PubMed ID: 25693203
PubMed ID: 28892079
Title: Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.
PubMed ID: 28892079
DOI: 10.1038/ncb3610
PubMed ID: 30122350
Title: Cell-Penetrating Peptide Mediates Intracellular Membrane Passage of Human Papillomavirus L2 Protein to Trigger Retrograde Trafficking.
PubMed ID: 30122350
PubMed ID: 30213940
Title: SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion.
PubMed ID: 30213940
PubMed ID: 17891154
Title: Functional architecture of the retromer cargo-recognition complex.
PubMed ID: 17891154
DOI: 10.1038/nature06216
PubMed ID: 21763482
PubMed ID: 21763483
Title: A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease.
PubMed ID: 21763483
PubMed ID: 22517097
Title: Identification of VPS35 mutations replicated in French families with Parkinson disease.
PubMed ID: 22517097
PubMed ID: 28397838
Title: Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families.
PubMed ID: 28397838
DOI: 10.1038/mp.2017.60
Sequence Information:
- Length: 796
- Mass: 91707
- Checksum: 28D2DD1C6B920A0A
- Sequence:
MPTTQQSPQD EQEKLLDEAI QAVKVQSFQM KRCLDKNKLM DALKHASNML GELRTSMLSP KSYYELYMAI SDELHYLEVY LTDEFAKGRK VADLYELVQY AGNIIPRLYL LITVGVVYVK SFPQSRKDIL KDLVEMCRGV QHPLRGLFLR NYLLQCTRNI LPDEGEPTDE ETTGDISDSM DFVLLNFAEM NKLWVRMQHQ GHSRDREKRE RERQELRILV GTNLVRLSQL EGVNVERYKQ IVLTGILEQV VNCRDALAQE YLMECIIQVF PDEFHLQTLN PFLRACAELH QNVNVKNIII ALIDRLALFA HREDGPGIPA DIKLFDIFSQ QVATVIQSRQ DMPSEDVVSL QVSLINLAMK CYPDRVDYVD KVLETTVEIF NKLNLEHIAT SSAVSKELTR LLKIPVDTYN NILTVLKLKH FHPLFEYFDY ESRKSMSCYV LSNVLDYNTE IVSQDQVDSI MNLVSTLIQD QPDQPVEDPD PEDFADEQSL VGRFIHLLRS EDPDQQYLIL NTARKHFGAG GNQRIRFTLP PLVFAAYQLA FRYKENSKVD DKWEKKCQKI FSFAHQTISA LIKAELAELP LRLFLQGALA AGEIGFENHE TVAYEFMSQA FSLYEDEISD SKAQLAAITL IIGTFERMKC FSEENHEPLR TQCALAASKL LKKPDQGRAV STCAHLFWSG RNTDKNGEEL HGGKRVMECL KKALKIANQC MDPSLQVQLF IEILNRYIYF YEKENDAVTI QVLNQLIQKI REDLPNLESS EETEQINKHF HNTLEHLRLR RESPESEGPI YEGLIL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.