ENAH | ENSG00000154380 | NCBI 55740

Details for: ENAH

Gene ID: 55740

Symbol: ENAH

Ensembl ID: ENSG00000154380

Description: ENAH actin regulator

Associated with

Adaptive immune system
(R-HSA-1280218)
Developmental biology
(R-HSA-1266738)
Generation of second messenger molecules
(R-HSA-202433)
Immune system
(R-HSA-168256)
Nervous system development
(R-HSA-9675108)
Signaling by robo receptors
(R-HSA-376176)
Tcr signaling
(R-HSA-202403)
Actin binding
(GO:0003779)
Actin polymerization-dependent cell motility
(GO:0070358)
Actin polymerization or depolymerization
(GO:0008154)
Axon guidance
(GO:0007411)
Cell junction
(GO:0030054)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Filopodium
(GO:0030175)
Focal adhesion
(GO:0005925)
Lamellipodium
(GO:0030027)
Plasma membrane
(GO:0005886)
Profilin binding
(GO:0005522)
Protein binding
(GO:0005515)
Sh3 domain binding
(GO:0017124)
Synapse
(GO:0045202)
Ww domain binding
(GO:0050699)

Other Information

Proteins

Protein enabled homolog
A0A4D6J698_HUMAN

Genular Protein ID: 357649801

Symbol: ENAH_HUMAN

Name: Protein enabled homolog

UniProtKB Accession Codes:

Q8N8S7 D0PQI2 Q502W5 Q5T5M7 Q5VTQ9 Q5VTR0 Q9NVF3 Q9UFB8

Database IDs:

Citations:

PubMed ID: 15027125

Title: Human Mena protein, a serex-defined antigen overexpressed in breast cancer eliciting both humoral and CD8+ T-cell immune response.

PubMed ID: 15027125

DOI: 10.1002/ijc.20094

PubMed ID: 23129656

Title: Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors.

PubMed ID: 23129656

DOI: 10.1073/pnas.1214394109

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11696321

Title: Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex.

PubMed ID: 11696321

DOI: 10.1016/s0960-9822(01)00506-1

PubMed ID: 9312002

Title: A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family.

PubMed ID: 9312002

DOI: 10.1093/emboj/16.17.5433

PubMed ID: 10801818

Title: Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins.

PubMed ID: 10801818

DOI: 10.1074/jbc.m001698200

PubMed ID: 12941633

Title: Robo4 is a vascular-specific receptor that inhibits endothelial migration.

PubMed ID: 12941633

DOI: 10.1016/s0012-1606(03)00258-6

PubMed ID: 15469846

Title: RIAM, an Ena/VASP and profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion.

PubMed ID: 15469846

DOI: 10.1016/j.devcel.2004.07.021

PubMed ID: 15469845

Title: Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics.

PubMed ID: 15469845

DOI: 10.1016/j.devcel.2004.07.024

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17686488

Title: Structural basis for polyproline recognition by the FE65 WW domain.

PubMed ID: 17686488

DOI: 10.1016/j.jmb.2007.06.064

PubMed ID: 18158903

Title: Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding.

PubMed ID: 18158903

DOI: 10.1016/j.molcel.2007.10.033

PubMed ID: 21278383

Title: Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A.

PubMed ID: 21278383

DOI: 10.1074/jbc.m110.171264

Sequence Information:

Length: 591
Mass: 66510
Checksum: BF3252F6FCD1988B
Sequence:

MSEQSICQAR AAVMVYDDAN KKWVPAGGST GFSRVHIYHH TGNNTFRVVG RKIQDHQVVI 
NCAIPKGLKY NQATQTFHQW RDARQVYGLN FGSKEDANVF ASAMMHALEV LNSQETGPTL 
PRQNSQLPAQ VQNGPSQEEL EIQRRQLQEQ QRQKELERER LERERMERER LERERLERER 
LERERLEQEQ LERERQERER QERLERQERL ERQERLERQE RLDRERQERQ ERERLERLER 
ERQERERQEQ LEREQLEWER ERRISSAAAP ASVETPLNSV LGDSSASEPG LQAASQPAET 
PSQQGIVLGP LAPPPPPPLP PGPAQASVAL PPPPGPPPPP PLPSTGPPPP PPPPPLPNQV 
PPPPPPPPAP PLPASGFFLA SMSEDNRPLT GLAAAIAGAK LRKVSRMEDT SFPSGGNAIG 
VNSASSKTDT GRGNGPLPLG GSGLMEEMSA LLARRRRIAE KGSTIETEQK EDKGEDSEPV 
TSKASSTSTP EPTRKPWERT NTMNGSKSPV ISRRDSPRKN QIVFDNRSYD SLHRPKSTPL 
SQPSANGVQT EGLDYDRLKQ DILDEMRKEL TKLKEELIDA IRQELSKSNT A

Genular Protein ID: 3399441358

Symbol: A0A4D6J698_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A4D6J698

Database IDs:

Sequence Information:

Length: 570
Mass: 63924
Checksum: 7BC390588F822497
Sequence:

MSEQSICQAR AAVMVYDDAN KKWVPAGGST GFSRVHIYHH TGNNTFRVVG RKIQDHQVVI 
NCAIPKGLKY NQATQTFHQW RDARQVYGLN FGSKEDANVF ASAMMHALEV LNSQETGPTL 
PRQNSQLPAQ VQNGPSQEEL EIQRRQLQEQ QRQKELERER LERERMERER LERERLERER 
LERERLEQEQ LERERQERER QERLERQERL ERQERLERQE RLDRERQERQ ERERLERLER 
ERQERERQEQ LEREQLEWER ERRISSAAAP ASVETPLNSV LGDSSASEPG LQAASQPAET 
PSQQGIVLGP LAPPPPPPLP PGPAQASVAL PPPPGPPPPP PLPSTGPPPP PPPPPLPNQV 
PPPPPPPPAP PLPASGFFLA SMSEDNRPLT GLAAAIAGAK LRKVSRMEDT SFPSGGNAIG 
VNSASSKTDT GRGNGPLPLG GSGLMEEMSA LLARRRRIAE KGSTIETEQK EDKGEDSEPV 
TSKASSTSTP EPTRKPWERT NTMNGSKSPV ISRPKSTPLS QPSANGVQTE GLDYDRLKQD 
ILDEMRKELT KLKEELIDAI RQELSKSNTA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ENAH

Associated with

Other Information

Human Mena protein, a serex-defined antigen overexpressed in breast cancer eliciting both humoral and CD8+ T-cell immune response. PubMed ID: 15027125

Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors. PubMed ID: 23129656

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex. PubMed ID: 11696321

A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family. PubMed ID: 9312002

Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins. PubMed ID: 10801818

Robo4 is a vascular-specific receptor that inhibits endothelial migration. PubMed ID: 12941633

RIAM, an Ena/VASP and profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. PubMed ID: 15469846

Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. PubMed ID: 15469845

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Structural basis for polyproline recognition by the FE65 WW domain. PubMed ID: 17686488

Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding. PubMed ID: 18158903

Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A. PubMed ID: 21278383