EDEM2 | ENSG00000088298 | NCBI 55741

Details for: EDEM2

Gene ID: 55741

Symbol: EDEM2

Ensembl ID: ENSG00000088298

Description: ER degradation enhancing alpha-mannosidase like protein 2

Associated with

Asparagine n-linked glycosylation
(R-HSA-446203)
Calnexin/calreticulin cycle
(R-HSA-901042)
Disease
(R-HSA-1643685)
Er quality control compartment (erqc)
(R-HSA-901032)
Infectious disease
(R-HSA-5663205)
Late sars-cov-2 infection events
(R-HSA-9772573)
Maturation of spike protein
(R-HSA-9694548)
Metabolism of proteins
(R-HSA-392499)
N-glycan trimming in the er and calnexin/calreticulin cycle
(R-HSA-532668)
Post-translational protein modification
(R-HSA-597592)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov infections
(R-HSA-9679506)
Translation of structural proteins
(R-HSA-9694635)
Viral infection pathways
(R-HSA-9824446)
Calcium ion binding
(GO:0005509)
Carbohydrate metabolic process
(GO:0005975)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum lumen
(GO:0005788)
Endoplasmic reticulum mannose trimming
(GO:1904380)
Endoplasmic reticulum quality control compartment
(GO:0044322)
Erad pathway
(GO:0036503)
Mannoprotein catabolic process
(GO:0006058)
Mannose trimming involved in glycoprotein erad pathway
(GO:1904382)
Mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
(GO:0004571)
Membrane
(GO:0016020)
Positive regulation of retrograde protein transport, er to cytosol
(GO:1904154)
Response to unfolded protein
(GO:0006986)
Viral protein processing
(GO:0019082)

Other Information

Proteins

ER degradation-enhancing alpha-mannosidase-like protein 2

Genular Protein ID: 1597308668

Symbol: EDEM2_HUMAN

Name: ER degradation-enhancing alpha-mannosidase-like protein 2

UniProtKB Accession Codes:

Q9BV94 B4DTG9 Q6GU33 Q6IA89 Q6UWZ4 Q9H4U0 Q9H886 Q9NTL9 Q9NVE6

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15537790

Title: Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins.

PubMed ID: 15537790

DOI: 10.1093/glycob/cwi014

PubMed ID: 25092655

Title: EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step.

PubMed ID: 25092655

DOI: 10.1083/jcb.201404075

Sequence Information:

Length: 578
Mass: 64753
Checksum: EEEADA069C159759
Sequence:

MPFRLLIPLG LLCALLPQHH GAPGPDGSAP DPAHYRERVK AMFYHAYDSY LENAFPFDEL 
RPLTCDGHDT WGSFSLTLID ALDTLLILGN VSEFQRVVEV LQDSVDFDID VNASVFETNI 
RVVGGLLSAH LLSKKAGVEV EAGWPCSGPL LRMAEEAARK LLPAFQTPTG MPYGTVNLLH 
GVNPGETPVT CTAGIGTFIV EFATLSSLTG DPVFEDVARV ALMRLWESRS DIGLVGNHID 
VLTGKWVAQD AGIGAGVDSY FEYLVKGAIL LQDKKLMAMF LEYNKAIRNY TRFDDWYLWV 
QMYKGTVSMP VFQSLEAYWP GLQSLIGDID NAMRTFLNYY TVWKQFGGLP EFYNIPQGYT 
VEKREGYPLR PELIESAMYL YRATGDPTLL ELGRDAVESI EKISKVECGF ATIKDLRDHK 
LDNRMESFFL AETVKYLYLL FDPTNFIHNN GSTFDAVITP YGECILGAGG YIFNTEAHPI 
DPAALHCCQR LKEEQWEVED LMREFYSLKR SRSKFQKNTV SSGPWEPPAR PGTLFSPENH 
DQARERKPAK QKVPLLSCPS QPFTSKLALL GQVFLDSS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: EDEM2

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins. PubMed ID: 15537790