Details for: CHFR

Gene ID: 55743

Symbol: CHFR

Ensembl ID: ENSG00000072609

Description: checkpoint with forkhead and ring finger domains

Associated with

Other Information

Genular Protein ID: 3769301445

Symbol: CHFR_HUMAN

Name: E3 ubiquitin-protein ligase CHFR

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10935642

Title: Chfr defines a mitotic stress checkpoint that delays entry into metaphase.

PubMed ID: 10935642

DOI: 10.1038/35019108

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11807090

Title: The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition.

PubMed ID: 11807090

DOI: 10.1083/jcb.200108016

PubMed ID: 11912157

Title: Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity.

PubMed ID: 11912157

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 11948416

Title: Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers.

PubMed ID: 11948416

DOI: 10.1038/sj.onc.1205402

PubMed ID: 12538348

Title: Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer.

PubMed ID: 12538348

DOI: 10.1093/carcin/24.1.47

PubMed ID: 12810945

Title: Epigenetic inactivation of CHFR in human tumors.

PubMed ID: 12810945

DOI: 10.1073/pnas.1337066100

PubMed ID: 14695171

Title: Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer.

PubMed ID: 14695171

PubMed ID: 14638868

Title: Promotion of mitosis by activated protein kinase B after DNA damage involves polo-like kinase 1 and checkpoint protein CHFR.

PubMed ID: 14638868

PubMed ID: 14562038

Title: The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains.

PubMed ID: 14562038

DOI: 10.1038/sj.onc.1206831

PubMed ID: 14694445

Title: CHFR-associated early G2/M checkpoint defects in breast cancer cells.

PubMed ID: 14694445

DOI: 10.1002/mc.10161

PubMed ID: 15467728

Title: PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein.

PubMed ID: 15467728

DOI: 10.1038/nsmb837

PubMed ID: 18172500

Title: Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins.

PubMed ID: 18172500

DOI: 10.1038/nature06420

PubMed ID: 18335050

Title: The anti-proliferative effects of the CHFR depend on the forkhead associated domain, but not E3 ligase activity mediated by ring finger domain.

PubMed ID: 18335050

DOI: 10.1371/journal.pone.0001776

PubMed ID: 19182791

Title: Chfr is linked to tumour metastasis through the downregulation of HDAC1.

PubMed ID: 19182791

DOI: 10.1038/ncb1837

PubMed ID: 12121644

Title: Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate.

PubMed ID: 12121644

DOI: 10.1016/s0969-2126(02)00776-1

PubMed ID: 14612512

Title: Inactivating mutations targeting the chfr mitotic checkpoint gene in human lung cancer.

PubMed ID: 14612512

Sequence Information:

  • Length: 664
  • Mass: 73386
  • Checksum: 141A1E7FEFAE36A2
  • Sequence:
  • MERPEEGKQS PPPQPWGRLL RLGAEEGEPH VLLRKREWTI GRRRGCDLSF PSNKLVSGDH 
    CRIVVDEKSG QVTLEDTSTS GTVINKLKVV KKQTCPLQTG DVIYLVYRKN EPEHNVAYLY 
    ESLSEKQGMT QESFEANKEN VFHGTKDTSG AGAGRGADPR VPPSSPATQV CFEEPQPSTS 
    TSDLFPTASA SSTEPSPAGR ERSSSCGSGG GGISPKGSGP SVASDEVSSF ASALPDRKTA 
    SFSSLEPQDQ EDLEPVKKKM RGDGDLDLNG QLLVAQPRRN AQTVHEDVRA AAGKPDKMEE 
    TLTCIICQDL LHDCVSLQPC MHTFCAACYS GWMERSSLCP TCRCPVERIC KNHILNNLVE 
    AYLIQHPDKS RSEEDVQSMD ARNKITQDML QPKVRRSFSD EEGSSEDLLE LSDVDSESSD 
    ISQPYVVCRQ CPEYRRQAAQ PPHCPAPEGE PGAPQALGDA PSTSVSLTTA VQDYVCPLQG 
    SHALCTCCFQ PMPDRRAERE QDPRVAPQQC AVCLQPFCHL YWGCTRTGCY GCLAPFCELN 
    LGDKCLDGVL NNNSYESDIL KNYLATRGLT WKNMLTESLV ALQRGVFLLS DYRVTGDTVL 
    CYCCGLRSFR ELTYQYRQNI PASELPVAVT SRPDCYWGRN CRTQVKAHHA MKFNHICEQT 
    RFKN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.