Details for: CHFR
Associated with
Other Information
Genular Protein ID: 3769301445
Symbol: CHFR_HUMAN
Name: E3 ubiquitin-protein ligase CHFR
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10935642
Title: Chfr defines a mitotic stress checkpoint that delays entry into metaphase.
PubMed ID: 10935642
DOI: 10.1038/35019108
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 11807090
Title: The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition.
PubMed ID: 11807090
PubMed ID: 11912157
Title: Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity.
PubMed ID: 11912157
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 11948416
Title: Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers.
PubMed ID: 11948416
PubMed ID: 12538348
Title: Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer.
PubMed ID: 12538348
PubMed ID: 12810945
Title: Epigenetic inactivation of CHFR in human tumors.
PubMed ID: 12810945
PubMed ID: 14695171
Title: Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer.
PubMed ID: 14695171
PubMed ID: 14638868
Title: Promotion of mitosis by activated protein kinase B after DNA damage involves polo-like kinase 1 and checkpoint protein CHFR.
PubMed ID: 14638868
PubMed ID: 14562038
Title: The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains.
PubMed ID: 14562038
PubMed ID: 14694445
Title: CHFR-associated early G2/M checkpoint defects in breast cancer cells.
PubMed ID: 14694445
DOI: 10.1002/mc.10161
PubMed ID: 15467728
Title: PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein.
PubMed ID: 15467728
DOI: 10.1038/nsmb837
PubMed ID: 18172500
Title: Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins.
PubMed ID: 18172500
DOI: 10.1038/nature06420
PubMed ID: 18335050
Title: The anti-proliferative effects of the CHFR depend on the forkhead associated domain, but not E3 ligase activity mediated by ring finger domain.
PubMed ID: 18335050
PubMed ID: 19182791
Title: Chfr is linked to tumour metastasis through the downregulation of HDAC1.
PubMed ID: 19182791
DOI: 10.1038/ncb1837
PubMed ID: 12121644
Title: Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate.
PubMed ID: 12121644
PubMed ID: 14612512
Title: Inactivating mutations targeting the chfr mitotic checkpoint gene in human lung cancer.
PubMed ID: 14612512
Sequence Information:
- Length: 664
- Mass: 73386
- Checksum: 141A1E7FEFAE36A2
- Sequence:
MERPEEGKQS PPPQPWGRLL RLGAEEGEPH VLLRKREWTI GRRRGCDLSF PSNKLVSGDH CRIVVDEKSG QVTLEDTSTS GTVINKLKVV KKQTCPLQTG DVIYLVYRKN EPEHNVAYLY ESLSEKQGMT QESFEANKEN VFHGTKDTSG AGAGRGADPR VPPSSPATQV CFEEPQPSTS TSDLFPTASA SSTEPSPAGR ERSSSCGSGG GGISPKGSGP SVASDEVSSF ASALPDRKTA SFSSLEPQDQ EDLEPVKKKM RGDGDLDLNG QLLVAQPRRN AQTVHEDVRA AAGKPDKMEE TLTCIICQDL LHDCVSLQPC MHTFCAACYS GWMERSSLCP TCRCPVERIC KNHILNNLVE AYLIQHPDKS RSEEDVQSMD ARNKITQDML QPKVRRSFSD EEGSSEDLLE LSDVDSESSD ISQPYVVCRQ CPEYRRQAAQ PPHCPAPEGE PGAPQALGDA PSTSVSLTTA VQDYVCPLQG SHALCTCCFQ PMPDRRAERE QDPRVAPQQC AVCLQPFCHL YWGCTRTGCY GCLAPFCELN LGDKCLDGVL NNNSYESDIL KNYLATRGLT WKNMLTESLV ALQRGVFLLS DYRVTGDTVL CYCCGLRSFR ELTYQYRQNI PASELPVAVT SRPDCYWGRN CRTQVKAHHA MKFNHICEQT RFKN
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.