Details for: INAVA

Gene ID: 55765

Symbol: INAVA

Ensembl ID: ENSG00000163362

Description: innate immunity activator

Associated with

  • Adherens junction maintenance
    (GO:0034334)
  • Cytoplasm
    (GO:0005737)
  • Innate immune response
    (GO:0045087)
  • Intestinal epithelial structure maintenance
    (GO:0060729)
  • Nuclear body
    (GO:0016604)
  • Nucleoplasm
    (GO:0005654)
  • Nucleotide-binding oligomerization domain containing 2 signaling pathway
    (GO:0070431)
  • Nucleus
    (GO:0005634)
  • Pattern recognition receptor signaling pathway
    (GO:0002221)
  • Positive regulation of canonical nf-kappab signal transduction
    (GO:0043123)
  • Positive regulation of cytokine production involved in immune response
    (GO:0002720)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-10 production
    (GO:0032733)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of protein ubiquitination
    (GO:0031398)
  • Positive regulation of stress-activated mapk cascade
    (GO:0032874)
  • Protein binding
    (GO:0005515)
  • Reactive oxygen species biosynthetic process
    (GO:1903409)
  • Response to muramyl dipeptide
    (GO:0032495)
  • Response to peptidoglycan
    (GO:0032494)

Other Information

Genular Protein ID: 3085904050

Symbol: INAVA_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q3KP66 B4E1K9 E9PFY0 Q9NV65 Q9NVI0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 20 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 4 SAM 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21983784

Title: Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.

PubMed ID: 21983784

DOI: 10.1038/ng.952

PubMed ID: 28436939

Title: An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes.

PubMed ID: 28436939

DOI: 10.1172/jci86282

PubMed ID: 29420262

Title: C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.

PubMed ID: 29420262

DOI: 10.1126/science.aan0814

Sequence Information:

  • Length: 663
  • Mass: 72914
  • Checksum: 77EB3D76DC55EF8A
  • Sequence:
    • MLQMPKLNEI PPGRAGRREA RGEGRWPGQT GPEAARLEWR AQGQAGGARA PWDSWGSSRL 
PTQPGPGWSR CPPSLLCALS FQKSTMESKD EVSDTDSGII LQSGPDSPVS PMKELTHAVH 
KQQRALEARL EACLEELRRL CLREAELTGT LPAEYPLKPG EKAPKVRRRI GAAYKLDDWA 
LHREDPLSSL ERQLALQLQI TEAARRLCLE ENLSRQARRQ RKHSMLQEEK KLQELQRCLV 
ERRRNSEPPP AAALPLGREL SASDDSSLSD GLLLEEEESQ VPKPPPESPA PPSRPLPPQT 
LEGLQPTGPE AGSPERAPVQ NSPWKETSLD HPYEKPRKSS EPWSESSSPA TTPQDGPSAS 
SLWLLEPASY HVVPIRGVPG QWQGRTSAPA TPEIQGRRGQ SQSLRVDSFR AGPEGRGRSA 
FPRRRPTHYT VTVPDSCFPA TKPPLPHAAC HSCSEDSGSD VSSISHPTSP GSSSPDISFL 
QPLSPPKTHR HRGAWVPAGS RELVAHHPKL LLPPGYFPAG RYVVVAESPL PPGEWELRRA 
APGPAYEEEG TPLRYQRLVP SRSRIVRTPS LKDSPAGRGL SKAAVSEELK WWHERARLRS 
TRPHSLDRQG AFRVRSLPLG REGFGRALGP RAQVPTVCVL RRSPDGAPVQ VFVPEKGEII 
SQV

Genular Protein ID: 3521538629

Symbol: A0A8V8N8P9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8N8P9

Database IDs:

CTD 1 EMBL 1 EPD 1 Ensembl 2 GO 1 GeneTree 1 HGNC 1 InterPro 2 KEGG 1 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 Pfam 2 Proteomes 2 RefSeq 1 SAM 1 SMR 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 677
  • Mass: 74319
  • Checksum: 61279690CD7E9481
  • Sequence:
    • MPQGTDVLGS LTFGMLQMPK LNEIPPGRAG RREARGEGRW PGQTGPEAAR LEWRAQGQAG 
GARAPWDSWG SSRLPTQPGP GWSRCPPSLL CALSFQKSTM ESKDEVSDTD SGIILQSGPD 
SPVSPMKELT HAVHKQQRAL EARLEACLEE LRRLCLREAE LTGTLPAEYP LKPGEKAPKV 
RRRIGAAYKL DDWALHREDP LSSLERQLAL QLQITEAARR LCLEENLSRQ ARRQRKHSML 
QEEKKLQELQ RCLVERRRNS EPPPAAALPL GRELSASDDS SLSDGLLLEE EESQVPKPPP 
ESPAPPSRPL PPQTLEGLQP TGPEAGSPER APVQNSPWKE TSLDHPYEKP RKSSEPWSES 
SSPATTPQDG PSASSLWLLE PASYHVVPIR GVPGQWQGRT SAPATPEIQG RRGQSQSLRV 
DSFRAGPEGR GRSAFPRRRP THYTVTVPDS CFPATKPPLP HAACHSCSED SGSDVSSISH 
PTSPGSSSPD ISFLQPLSPP KTHRHRGAWV PAGSRELVAH HPKLLLPPGY FPAGRYVVVA 
ESPLPPGEWE LRRAAPGPAY EEEGTPLRYQ RLVPSRSRIV RTPSLKDSPA GRGLSKAAVS 
EELKWWHERA RLRSTRPHSL DRQGAFRVRS LPLGREGFGR ALGPRAQVPT VCVLRRSPDG 
APVQVFVPEK GEIISQV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.