Details for: NGLY1
Associated with
Other Information
Genular Protein ID: 2113716294
Symbol: NGLY1_HUMAN
Name: Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10831608
Title: PNG1, a yeast gene encoding a highly conserved peptide:N-glycanase.
PubMed ID: 10831608
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15362974
Title: A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs.
PubMed ID: 15362974
DOI: 10.1042/bj20041498
PubMed ID: 14749736
Title: A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised.
PubMed ID: 14749736
PubMed ID: 15358861
Title: A complex between peptide:N-glycanase and two proteasome-linked proteins suggests a mechanism for the degradation of misfolded glycoproteins.
PubMed ID: 15358861
PubMed ID: 15610852
Title: Using a small molecule inhibitor of peptide: N-glycanase to probe its role in glycoprotein turnover.
PubMed ID: 15610852
PubMed ID: 16055502
Title: The retrotranslocation protein derlin-1 binds peptide:N-glycanase to the endoplasmic reticulum.
PubMed ID: 16055502
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 22581936
Title: Clinical application of exome sequencing in undiagnosed genetic conditions.
PubMed ID: 22581936
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24651605
Title: Mutations in NGLY1 cause an inherited disorder of the endoplasmic reticulum-associated degradation pathway.
PubMed ID: 24651605
DOI: 10.1038/gim.2014.22
PubMed ID: 16807242
Title: The PUB domain functions as a p97 binding module in human peptide N-glycanase.
PubMed ID: 16807242
Sequence Information:
- Length: 654
- Mass: 74390
- Checksum: 94BD44316EA66AF6
- Sequence:
MAAAALGSSS GSASPAVAEL CQNTPETFLE ASKLLLTYAD NILRNPNDEK YRSIRIGNTA FSTRLLPVRG AVECLFEMGF EEGETHLIFP KKASVEQLQK IRDLIAIERS SRLDGSNKSH KVKSSQQPAA STQLPTTPSS NPSGLNQHTR NRQGQSSDPP SASTVAADSA ILEVLQSNIQ HVLVYENPAL QEKALACIPV QELKRKSQEK LSRARKLDKG INISDEDFLL LELLHWFKEE FFHWVNNVLC SKCGGQTRSR DRSLLPSDDE LKWGAKEVED HYCDACQFSN RFPRYNNPEK LLETRCGRCG EWANCFTLCC RAVGFEARYV WDYTDHVWTE VYSPSQQRWL HCDACEDVCD KPLLYEIGWG KKLSYVIAFS KDEVVDVTWR YSCKHEEVIA RRTKVKEALL RDTINGLNKQ RQLFLSENRR KELLQRIIVE LVEFISPKTP KPGELGGRIS GSVAWRVARG EMGLQRKETL FIPCENEKIS KQLHLCYNIV KDRYVRVSNN NQTISGWENG VWKMESIFRK VETDWHMVYL ARKEGSSFAY ISWKFECGSV GLKVDSISIR TSSQTFQTGT VEWKLRSDTA QVELTGDNSL HSYADFSGAT EVILEAELSR GDGDVAWQHT QLFRQSLNDH EENCLEIIIK FSDL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.