Details for: AXL

Gene ID: 558

Symbol: AXL

Ensembl ID: ENSG00000167601

Description: AXL receptor tyrosine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 213.2499
    Cell Significance Index: -33.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 131.3261
    Cell Significance Index: -33.3100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 66.9741
    Cell Significance Index: -31.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.8947
    Cell Significance Index: -33.1600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.8276
    Cell Significance Index: -19.3200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.4287
    Cell Significance Index: -33.2600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 6.2180
    Cell Significance Index: 42.1300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 5.0775
    Cell Significance Index: 42.6500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.6023
    Cell Significance Index: 14.1900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.5227
    Cell Significance Index: 72.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.0547
    Cell Significance Index: 55.0600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.8576
    Cell Significance Index: 28.7400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.5842
    Cell Significance Index: 30.9200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.3604
    Cell Significance Index: 68.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.0789
    Cell Significance Index: 34.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0706
    Cell Significance Index: 137.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0475
    Cell Significance Index: 143.8500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8097
    Cell Significance Index: 22.0400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5996
    Cell Significance Index: 12.5500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.5572
    Cell Significance Index: 7.8200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.5188
    Cell Significance Index: 7.4500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.5057
    Cell Significance Index: 2.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3308
    Cell Significance Index: 62.9600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2649
    Cell Significance Index: 168.2300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2499
    Cell Significance Index: 6.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2120
    Cell Significance Index: 9.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1617
    Cell Significance Index: 18.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1234
    Cell Significance Index: 111.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0996
    Cell Significance Index: 187.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0853
    Cell Significance Index: 131.3100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0790
    Cell Significance Index: 34.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0764
    Cell Significance Index: 140.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0466
    Cell Significance Index: 0.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0224
    Cell Significance Index: 10.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0049
    Cell Significance Index: 2.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0069
    Cell Significance Index: -1.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0094
    Cell Significance Index: -1.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0106
    Cell Significance Index: -1.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0146
    Cell Significance Index: -1.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0186
    Cell Significance Index: -3.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0193
    Cell Significance Index: -26.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0322
    Cell Significance Index: -1.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0340
    Cell Significance Index: -23.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0386
    Cell Significance Index: -28.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0417
    Cell Significance Index: -31.6000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0441
    Cell Significance Index: -0.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0480
    Cell Significance Index: -17.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0493
    Cell Significance Index: -36.5500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0568
    Cell Significance Index: -1.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0631
    Cell Significance Index: -35.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0658
    Cell Significance Index: -41.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0687
    Cell Significance Index: -1.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0894
    Cell Significance Index: -25.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0912
    Cell Significance Index: -9.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1002
    Cell Significance Index: -19.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1083
    Cell Significance Index: -6.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1131
    Cell Significance Index: -22.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1161
    Cell Significance Index: -12.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1293
    Cell Significance Index: -6.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1400
    Cell Significance Index: -3.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1752
    Cell Significance Index: -36.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2013
    Cell Significance Index: -15.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2074
    Cell Significance Index: -26.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2085
    Cell Significance Index: -35.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2269
    Cell Significance Index: -13.9100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2348
    Cell Significance Index: -4.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2364
    Cell Significance Index: -16.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2547
    Cell Significance Index: -26.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2783
    Cell Significance Index: -32.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2913
    Cell Significance Index: -17.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3063
    Cell Significance Index: -21.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3119
    Cell Significance Index: -35.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3273
    Cell Significance Index: -7.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3292
    Cell Significance Index: -25.2700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3759
    Cell Significance Index: -29.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4167
    Cell Significance Index: -25.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4897
    Cell Significance Index: -31.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4942
    Cell Significance Index: -33.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4998
    Cell Significance Index: -25.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5164
    Cell Significance Index: -26.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5312
    Cell Significance Index: -18.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5589
    Cell Significance Index: -35.2300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5825
    Cell Significance Index: -4.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6260
    Cell Significance Index: -32.8700
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.6305
    Cell Significance Index: -5.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6681
    Cell Significance Index: -17.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7046
    Cell Significance Index: -19.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.7074
    Cell Significance Index: -32.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7438
    Cell Significance Index: -32.9000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.7490
    Cell Significance Index: -12.9500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8518
    Cell Significance Index: -31.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8683
    Cell Significance Index: -32.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8769
    Cell Significance Index: -30.7200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.9077
    Cell Significance Index: -18.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.9119
    Cell Significance Index: -24.3500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.9291
    Cell Significance Index: -40.4000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.9396
    Cell Significance Index: -20.0900
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.9464
    Cell Significance Index: -5.5600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9545
    Cell Significance Index: -28.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9632
    Cell Significance Index: -24.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AXL is a receptor tyrosine kinase that belongs to the TAM (Tyro3, AXL, and Mer) family of receptors. It is characterized by its ability to bind to its ligand, growth arrest-specific 6 (Gas6), which triggers a signaling cascade that regulates various cellular processes. AXL is also known for its high expression levels in cancer cells, where it contributes to tumor progression, metastasis, and resistance to therapy. The gene's product, UFO (Tyrosine-protein kinase receptor UFO), is a transmembrane receptor protein tyrosine kinase that undergoes dimerization and autophosphorylation upon Gas6 binding. **Pathways and Functions:** AXL's signaling pathway is complex and involves multiple downstream targets, including PI3K/AKT, MAPK/ERK, and JNK. This pathway regulates various cellular processes, including: 1. **Immune regulation:** AXL modulates cytokine production, dendritic cell differentiation, and natural killer cell activation, highlighting its importance in immune response and tolerance. 2. **Cell migration and proliferation:** AXL promotes cell migration, invasion, and proliferation, which are essential for tumor progression and metastasis. 3. **Apoptosis regulation:** AXL negatively regulates apoptosis, contributing to tumor cell survival and resistance to therapy. 4. **Extracellular matrix remodeling:** AXL interacts with the extracellular matrix, regulating cell adhesion, migration, and invasion. **Clinical Significance:** AXL's involvement in cancer progression and metastasis makes it a promising therapeutic target. Recent studies have explored the use of AXL inhibitors in cancer therapy, which have shown promising results in preclinical models. Additionally, AXL's role in immune regulation highlights its potential as a target for immunotherapy. Furthermore, AXL's involvement in vascular remodeling and angiogenesis suggests its potential as a target for cardiovascular disease treatment. In conclusion, AXL is a complex receptor tyrosine kinase that plays a multifaceted role in immune regulation, cell migration, proliferation, and survival. Its involvement in cancer progression and metastasis makes it a promising therapeutic target, while its role in immune regulation highlights its potential as a target for immunotherapy. Further research is needed to fully elucidate the mechanisms of AXL and its clinical significance. **Significantly expressed cells:** * CD14-positive, CD16-negative classical monocyte * Skeletal muscle fibroblast * Contractile cell * Kupffer cell * Fibroblast of connective tissue of glandular part of prostate * Inflammatory cell * Decidual cell * Fibroblast of mammary gland * Fibroblast of connective tissue of prostate * Mature alpha-beta T cell **Proteins:** * UFO_HUMAN (Tyrosine-protein kinase receptor UFO) * M0R0W6_HUMAN

Genular Protein ID: 3788044498

Symbol: UFO_HUMAN

Name: Tyrosine-protein kinase receptor UFO

UniProtKB Accession Codes:

P30530 Q8N5L2 Q9UD27

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 4 CORUM 1 CPTAC 2 CPTC 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 55 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2247464

Title: Putative tyrosine kinases expressed in K-562 human leukemia cells.

PubMed ID: 2247464

DOI: 10.1073/pnas.87.22.8913

PubMed ID: 1656220

Title: AXL, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase.

PubMed ID: 1656220

DOI: 10.1128/mcb.11.10.5016-5031.1991

PubMed ID: 1834974

Title: A novel putative tyrosine kinase receptor with oncogenic potential.

PubMed ID: 1834974

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8247543

Title: A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.

PubMed ID: 8247543

PubMed ID: 7896447

Title: Receptor tyrosine kinases expressed in metastatic colon cancer.

PubMed ID: 7896447

DOI: 10.1002/ijc.2910600611

PubMed ID: 7854420

Title: Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6.

PubMed ID: 7854420

DOI: 10.1038/373623a0

PubMed ID: 8621659

Title: Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl.

PubMed ID: 8621659

DOI: 10.1074/jbc.271.16.9785

PubMed ID: 9178760

Title: Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.

PubMed ID: 9178760

DOI: 10.1038/sj.onc.1201123

PubMed ID: 10403904

Title: A receptor tyrosine kinase, UFO/Axl, and other genes isolated by a modified differential display PCR are overexpressed in metastatic prostatic carcinoma cell line DU145.

PubMed ID: 10403904

DOI: 10.1046/j.1525-1500.1999.99034.x

PubMed ID: 11484958

Title: Estrogen dependent expression of the receptor tyrosine kinase axl in normal and malignant human breast.

PubMed ID: 11484958

DOI: 10.1023/a:1011126330233

PubMed ID: 12470648

Title: Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin.

PubMed ID: 12470648

DOI: 10.1016/s0006-291x(02)02718-3

PubMed ID: 12364394

Title: Acidification prevents endothelial cell apoptosis by Axl activation.

PubMed ID: 12364394

DOI: 10.1161/01.res.0000036753.50601.e9

PubMed ID: 12490074

Title: Expression of receptor-type tyrosine kinase, Axl, and its ligand, Gas6, in pediatric thyroid carcinomas around Chernobyl.

PubMed ID: 12490074

DOI: 10.1089/105072502320908303

PubMed ID: 15958209

Title: Effects of Gas6 and hydrogen peroxide in Axl ubiquitination and downregulation.

PubMed ID: 15958209

DOI: 10.1016/j.bbrc.2005.05.086

PubMed ID: 15507525

Title: Inhibition of vascular endothelial growth factor receptor 2-mediated endothelial cell activation by Axl tyrosine kinase receptor.

PubMed ID: 15507525

DOI: 10.1182/blood-2004-04-1469

PubMed ID: 15733062

Title: Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses.

PubMed ID: 15733062

DOI: 10.1111/j.1538-7836.2005.01186.x

PubMed ID: 17005688

Title: Tyro3 family-mediated cell entry of Ebola and Marburg viruses.

PubMed ID: 17005688

DOI: 10.1128/jvi.01157-06

PubMed ID: 18346204

Title: In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation.

PubMed ID: 18346204

DOI: 10.1111/j.1471-4159.2008.05343.x

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18840707

Title: The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development.

PubMed ID: 18840707

DOI: 10.1182/blood-2008-05-157073

PubMed ID: 19815557

Title: Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling.

PubMed ID: 19815557

DOI: 10.1074/jbc.m109.072660

PubMed ID: 21501828

Title: The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry.

PubMed ID: 21501828

DOI: 10.1016/j.chom.2011.03.012

PubMed ID: 22156524

Title: Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry.

PubMed ID: 22156524

DOI: 10.1128/jvi.06451-11

PubMed ID: 22673088

Title: Cell surface molecules involved in infection mediated by lymphocytic choriomeningitis virus glycoprotein.

PubMed ID: 22673088

DOI: 10.1292/jvms.12-0176

PubMed ID: 25277499

Title: Phosphatidylserine receptors: enhancers of enveloped virus entry and infection.

PubMed ID: 25277499

DOI: 10.1016/j.virol.2014.09.009

PubMed ID: 28076778

Title: Axl Mediates ZIKA Virus Entry in Human Glial Cells and Modulates Innate Immune Responses.

PubMed ID: 28076778

DOI: 10.1016/j.celrep.2016.12.045

PubMed ID: 29507355

Title: Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-beta receptor.

PubMed ID: 29507355

DOI: 10.1038/s41590-018-0063-9

PubMed ID: 29379210

Title: AXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling.

PubMed ID: 29379210

DOI: 10.1038/s41564-017-0092-4

PubMed ID: 31311882

Title: Axl Promotes Zika Virus Entry and Modulates the Antiviral State of Human Sertoli Cells.

PubMed ID: 31311882

DOI: 10.1128/mbio.01372-19

PubMed ID: 16362042

Title: Structural basis for Gas6-Axl signalling.

PubMed ID: 16362042

DOI: 10.1038/sj.emboj.7600912

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 894
  • Mass: 98337
  • Checksum: 262D3659218E3202
  • Sequence:
    • MAWRCPRMGR VPLAWCLALC GWACMAPRGT QAEESPFVGN PGNITGARGL TGTLRCQLQV 
QGEPPEVHWL RDGQILELAD STQTQVPLGE DEQDDWIVVS QLRITSLQLS DTGQYQCLVF 
LGHQTFVSQP GYVGLEGLPY FLEEPEDRTV AANTPFNLSC QAQGPPEPVD LLWLQDAVPL 
ATAPGHGPQR SLHVPGLNKT SSFSCEAHNA KGVTTSRTAT ITVLPQQPRN LHLVSRQPTE 
LEVAWTPGLS GIYPLTHCTL QAVLSDDGMG IQAGEPDPPE EPLTSQASVP PHQLRLGSLH 
PHTPYHIRVA CTSSQGPSSW THWLPVETPE GVPLGPPENI SATRNGSQAF VHWQEPRAPL 
QGTLLGYRLA YQGQDTPEVL MDIGLRQEVT LELQGDGSVS NLTVCVAAYT AAGDGPWSLP 
VPLEAWRPGQ AQPVHQLVKE PSTPAFSWPW WYVLLGAVVA AACVLILALF LVHRRKKETR 
YGEVFEPTVE RGELVVRYRV RKSYSRRTTE ATLNSLGISE ELKEKLRDVM VDRHKVALGK 
TLGEGEFGAV MEGQLNQDDS ILKVAVKTMK IAICTRSELE DFLSEAVCMK EFDHPNVMRL 
IGVCFQGSER ESFPAPVVIL PFMKHGDLHS FLLYSRLGDQ PVYLPTQMLV KFMADIASGM 
EYLSTKRFIH RDLAARNCML NENMSVCVAD FGLSKKIYNG DYYRQGRIAK MPVKWIAIES 
LADRVYTSKS DVWSFGVTMW EIATRGQTPY PGVENSEIYD YLRQGNRLKQ PADCLDGLYA 
LMSRCWELNP QDRPSFTELR EDLENTLKAL PPAQEPDEIL YVNMDEGGGY PEPPGAAGGA 
DPPTQPDPKD SCSCLTAAEV HPAGRYVLCP STTPSPAQPA DRGSPAAPGQ EDGA

Genular Protein ID: 3229020786

Symbol: M0R0W6_HUMAN

Name: N/A

UniProtKB Accession Codes:

M0R0W6

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 6 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 10 MINT 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 3 SAM 2 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

Sequence Information:

  • Length: 626
  • Mass: 69231
  • Checksum: 66372173936B138F
  • Sequence:
    • MGIQAGEPDP PEEPLTSQAS VPPHQLRLGS LHPHTPYHIR VACTSSQGPS SWTHWLPVET 
PEGVPLGPPE NISATRNGSQ AFVHWQEPRA PLQGTLLGYR LAYQGQDTPE VLMDIGLRQE 
VTLELQGDGS VSNLTVCVAA YTAAGDGPWS LPVPLEAWRP GQAQPVHQLV KEPSTPAFSW 
PWWYVLLGAV VAAACVLILA LFLVHRRKKE TRYGEVFEPT VERGELVVRY RVRKSYSRRT 
TEATLNSLGI SEELKEKLRD VMVDRHKVAL GKTLGEGEFG AVMEGQLNQD DSILKVAVKT 
MKIAICTRSE LEDFLSEAVC MKEFDHPNVM RLIGVCFQGS ERESFPAPVV ILPFMKHGDL 
HSFLLYSRLG DQPVYLPTQM LVKFMADIAS GMEYLSTKRF IHRDLAARNC MLNENMSVCV 
ADFGLSKKIY NGDYYRQGRI AKMPVKWIAI ESLADRVYTS KSDVWSFGVT MWEIATRGQT 
PYPGVENSEI YDYLRQGNRL KQPADCLDGL YALMSRCWEL NPQDRPSFTE LREDLENTLK 
ALPPAQEPDE ILYVNMDEGG GYPEPPGAAG GADPPTQPDP KDSCSCLTAA EVHPAGRYVL 
CPSTTPSPAQ PADRGSPAAP GQEDGA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.