SCN3B | ENSG00000166257 | NCBI 55800

Details for: SCN3B

Gene ID: 55800

Symbol: SCN3B

Ensembl ID: ENSG00000166257

Description: sodium voltage-gated channel beta subunit 3

Associated with

Axon guidance
(R-HSA-422475)
Cardiac conduction
(R-HSA-5576891)
Developmental biology
(R-HSA-1266738)
Interaction between l1 and ankyrins
(R-HSA-445095)
L1cam interactions
(R-HSA-373760)
Muscle contraction
(R-HSA-397014)
Phase 0 - rapid depolarisation
(R-HSA-5576892)
Atrial cardiac muscle cell action potential
(GO:0086014)
Cardiac muscle cell action potential involved in contraction
(GO:0086002)
Cardiac muscle contraction
(GO:0060048)
Membrane
(GO:0016020)
Membrane depolarization
(GO:0051899)
Membrane depolarization during action potential
(GO:0086010)
Membrane depolarization during cardiac muscle cell action potential
(GO:0086012)
Nervous system development
(GO:0007399)
Plasma membrane
(GO:0005886)
Positive regulation of heart rate
(GO:0010460)
Positive regulation of sodium ion transport
(GO:0010765)
Protein binding
(GO:0005515)
Protein localization to plasma membrane
(GO:0072659)
Regulation of atrial cardiac muscle cell membrane depolarization
(GO:0060371)
Regulation of heart rate by cardiac conduction
(GO:0086091)
Regulation of sodium ion transmembrane transporter activity
(GO:2000649)
Regulation of ventricular cardiac muscle cell membrane depolarization
(GO:0060373)
Sa node cell action potential
(GO:0086015)
Sodium channel inhibitor activity
(GO:0019871)
Sodium channel regulator activity
(GO:0017080)
Sodium ion transmembrane transport
(GO:0035725)
Sodium ion transport
(GO:0006814)
Transmembrane transporter binding
(GO:0044325)
Ventricular cardiac muscle cell action potential
(GO:0086005)
Voltage-gated sodium channel activity involved in cardiac muscle cell action potential
(GO:0086006)
Voltage-gated sodium channel complex
(GO:0001518)
Z disc
(GO:0030018)

Other Information

Proteins

Sodium channel subunit beta-3

Genular Protein ID: 2230856086

Symbol: SCN3B_HUMAN

Name: Sodium channel subunit beta-3

UniProtKB Accession Codes:

Q9NY72 A5H1I5 Q17RL3 Q9ULR2

Database IDs:

Citations:

PubMed ID: 10688874

Title: Beta3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics.

PubMed ID: 10688874

DOI: 10.1073/pnas.030362197

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 10574461

Title: Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.

PubMed ID: 10574461

DOI: 10.1093/dnares/6.5.329

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 20031595

Title: A mutation in the beta-3 subunit of the cardiac sodium channel associated with Brugada ECG phenotype.

PubMed ID: 20031595

DOI: 10.1161/circgenetics.108.829192

PubMed ID: 20558140

Title: Functional dominant-negative mutation of sodium channel subunit gene SCN3B associated with atrial fibrillation in a Chinese GeneID population.

PubMed ID: 20558140

DOI: 10.1016/j.bbrc.2010.06.042

PubMed ID: 20042427

Title: Loss-of-function mutation of the SCN3B-encoded sodium channel {beta}3 subunit associated with a case of idiopathic ventricular fibrillation.

PubMed ID: 20042427

DOI: 10.1093/cvr/cvp417

PubMed ID: 21051419

Title: Mutations in sodium channel beta-subunit SCN3B are associated with early-onset lone atrial fibrillation.

PubMed ID: 21051419

DOI: 10.1093/cvr/cvq348

Sequence Information:

Length: 215
Mass: 24702
Checksum: 70F6C604E9E26662
Sequence:

MPAFNRLFPL ASLVLIYWVS VCFPVCVEVP SETEAVQGNP MKLRCISCMK REEVEATTVV 
EWFYRPEGGK DFLIYEYRNG HQEVESPFQG RLQWNGSKDL QDVSITVLNV TLNDSGLYTC 
NVSREFEFEA HRPFVKTTRL IPLRVTEEAG EDFTSVVSEI MMYILLVFLT LWLLIEMIYC 
YRKVSKAEEA AQENASDYLA IPSENKENSA VPVEE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SCN3B

Associated with

Other Information

Beta3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics. PubMed ID: 10688874

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. PubMed ID: 10574461

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

A mutation in the beta-3 subunit of the cardiac sodium channel associated with Brugada ECG phenotype. PubMed ID: 20031595

Functional dominant-negative mutation of sodium channel subunit gene SCN3B associated with atrial fibrillation in a Chinese GeneID population. PubMed ID: 20558140

Loss-of-function mutation of the SCN3B-encoded sodium channel {beta}3 subunit associated with a case of idiopathic ventricular fibrillation. PubMed ID: 20042427

Mutations in sodium channel beta-subunit SCN3B are associated with early-onset lone atrial fibrillation. PubMed ID: 21051419