DCP1A | ENSG00000272886 | NCBI 55802

Details for: DCP1A

Gene ID: 55802

Symbol: DCP1A

Ensembl ID: ENSG00000272886

Description: decapping mRNA 1A

Associated with

Butyrate response factor 1 (brf1) binds and destabilizes mrna
(R-HSA-450385)
Deadenylation-dependent mrna decay
(R-HSA-429914)
Metabolism of rna
(R-HSA-8953854)
Mrna decay by 5' to 3' exoribonuclease
(R-HSA-430039)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Tristetraprolin (ttp, zfp36) binds and destabilizes mrna
(R-HSA-450513)
5'-(n(7)-methylguanosine 5'-triphospho)-[mrna] hydrolase activity
(GO:0140933)
Cytoplasm
(GO:0005737)
Cytoplasmic ribonucleoprotein granule
(GO:0036464)
Cytosol
(GO:0005829)
Deadenylation-dependent decapping of nuclear-transcribed mrna
(GO:0000290)
Deadenylation-independent decapping of nuclear-transcribed mrna
(GO:0031087)
Enzyme activator activity
(GO:0008047)
Identical protein binding
(GO:0042802)
Kinesin binding
(GO:0019894)
Membrane
(GO:0016020)
Methylguanosine-cap decapping
(GO:0110156)
Mrna binding
(GO:0003729)
Nuclear-transcribed mrna catabolic process, nonsense-mediated decay
(GO:0000184)
Nucleus
(GO:0005634)
P-body
(GO:0000932)
Protein binding
(GO:0005515)
Protein localization to cytoplasmic stress granule
(GO:1903608)

Other Information

Proteins

mRNA-decapping enzyme 1A

Genular Protein ID: 2790827260

Symbol: DCP1A_HUMAN

Name: mRNA-decapping enzyme 1A

UniProtKB Accession Codes:

Q9NPI6 B4DHN9 U3KQM8

Database IDs:

Citations:

PubMed ID: 12417715

Title: Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay.

PubMed ID: 12417715

DOI: 10.1128/mcb.22.23.8114-8121.2002

PubMed ID: 11836524

Title: SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling.

PubMed ID: 11836524

DOI: 10.1038/ncb753

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12515382

Title: The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.

PubMed ID: 12515382

PubMed ID: 15687258

Title: Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1.

PubMed ID: 15687258

DOI: 10.1101/gad.1282305

PubMed ID: 16364915

Title: Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping.

PubMed ID: 16364915

DOI: 10.1016/j.molcel.2005.10.031

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19150429

Title: Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex.

PubMed ID: 19150429

DOI: 10.1016/j.molcel.2008.11.022

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21876179

Title: Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation.

PubMed ID: 21876179

DOI: 10.1073/pnas.1101676108

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25220460

Title: The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex.

PubMed ID: 25220460

DOI: 10.1016/j.celrep.2014.08.020

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 27918561

Title: A human microprotein that interacts with the mRNA decapping complex.

PubMed ID: 27918561

DOI: 10.1038/nchembio.2249

PubMed ID: 30258011

Title: Rotavirus Induces Formation of Remodeled Stress Granules and P Bodies and Their Sequestration in Viroplasms To Promote Progeny Virus Production.

PubMed ID: 30258011

DOI: 10.1128/jvi.01363-18

PubMed ID: 33813271

Title: mRNA decapping factor Dcp1a is essential for embryonic growth in mice.

PubMed ID: 33813271

DOI: 10.1016/j.bbrc.2021.03.117

Sequence Information:

Length: 582
Mass: 63278
Checksum: 26480D0B10CE7C72
Sequence:

MEALSRAGQE MSLAALKQHD PYITSIADLT GQVALYTFCP KANQWEKTDI EGTLFVYRRS 
ASPYHGFTIV NRLNMHNLVE PVNKDLEFQL HEPFLLYRNA SLSIYSIWFY DKNDCHRIAK 
LMADVVEEET RRSQQAARDK QSPSQANGCS DHRPIDILEM LSRAKDEYER NQMGDSNISS 
PGLQPSTQLS NLGSTETLEE MPSGSQDKSA PSGHKHLTVE ELFGTSLPKE QPAVVGLDSE 
EMERLPGDAS QKEPNSFLPF PFEQLGGAPQ SETLGVPSAA HHSVQPEITT PVLITPASIT 
QSNEKHAPTY TIPLSPVLSP TLPAEAPTAQ VPPSLPRNST MMQAVKTTPR QRSPLLNQPV 
PELSHASLIA NQSPFRAPLN VTNTAGTSLP SVDLLQKLRL TPQHDQIQTQ PLGKGAMVAS 
FSPAAGQLAT PESFIEPPSK TAAARVAASA SLSNMVLAPL QSMQQNQDPE VFVQPKVLSS 
AIPVAGAPLV TATTTAVSSV LLAPSVFQQT VTRSSDLERK ASSPSPLTIG TPESQRKPSI 
ILSKSQLQDT LIHLIKNDSS FLSTLHEVYL QVLTKNKDNH NL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: DCP1A

Associated with

Other Information

Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. PubMed ID: 12417715

SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling. PubMed ID: 11836524

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. PubMed ID: 12515382

Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1. PubMed ID: 15687258

Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. PubMed ID: 16364915

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex. PubMed ID: 19150429

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation. PubMed ID: 21876179

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex. PubMed ID: 25220460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

A human microprotein that interacts with the mRNA decapping complex. PubMed ID: 27918561

Rotavirus Induces Formation of Remodeled Stress Granules and P Bodies and Their Sequestration in Viroplasms To Promote Progeny Virus Production. PubMed ID: 30258011

mRNA decapping factor Dcp1a is essential for embryonic growth in mice. PubMed ID: 33813271