Details for: HR

Gene ID: 55806

Symbol: HR

Ensembl ID: ENSG00000168453

Description: HR lysine demethylase and nuclear receptor corepressor

Associated with

Other Information

Genular Protein ID: 2623880042

Symbol: HAIR_HUMAN

Name: Lysine-specific demethylase hairless

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9445480

Title: Alopecia universalis associated with a mutation in the human hairless gene.

PubMed ID: 9445480

DOI: 10.1126/science.279.5351.720

PubMed ID: 10051399

Title: Genomic organization of the human hairless gene (HR) and identification of a mutation underlying congenital atrichia in an Arab Palestinian family.

PubMed ID: 10051399

DOI: 10.1006/geno.1998.5699

PubMed ID: 9736769

Title: Cloning, genomic organization, alternative transcripts and mutational analysis of the gene responsible for autosomal recessive universal congenital alopecia.

PubMed ID: 9736769

DOI: 10.1093/hmg/7.11.1671

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19122663

Title: Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis.

PubMed ID: 19122663

DOI: 10.1038/ng.276

PubMed ID: 24334705

Title: Hairless is a histone H3K9 demethylase.

PubMed ID: 24334705

DOI: 10.1096/fj.13-237677

PubMed ID: 9758627

Title: A missense mutation in the zinc-finger domain of the human hairless gene underlies congenital atrichia in a family of Irish travellers.

PubMed ID: 9758627

DOI: 10.1086/302069

PubMed ID: 11410842

Title: Variant 1859G-->A (Arg620Gln) of the 'hairless' gene: absence of association with papular atrichia or androgenic alopecia.

PubMed ID: 11410842

DOI: 10.1086/321273

PubMed ID: 12406339

Title: A novel missense mutation affecting the human hairless thyroid receptor interacting domain 2 causes congenital atrichia.

PubMed ID: 12406339

DOI: 10.1046/j.1523-1747.2002.00268.x

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 24961381

Title: Identification of a novel U2HR mutation in a Korean woman with Marie Unna hereditary hypotrichosis.

PubMed ID: 24961381

DOI: 10.1111/ijd.12545

Sequence Information:

  • Length: 1189
  • Mass: 127495
  • Checksum: 67A4B95A01063387
  • Sequence:
  • MESTPSFLKG TPTWEKTAPE NGIVRQEPGS PPRDGLHHGP LCLGEPAPFW RGVLSTPDSW 
    LPPGFPQGPK DMLPLVEGEG PQNGERKVNW LGSKEGLRWK EAMLTHPLAF CGPACPPRCG 
    PLMPEHSGGH LKSDPVAFRP WHCPFLLETK ILERAPFWVP TCLPPYLVSG LPPEHPCDWP 
    LTPHPWVYSG GQPKVPSAFS LGSKGFYYKD PSIPRLAKEP LAAAEPGLFG LNSGGHLQRA 
    GEAERPSLHQ RDGEMGAGRQ QNPCPLFLGQ PDTVPWTSWP ACPPGLVHTL GNVWAGPGDG 
    NLGYQLGPPA TPRCPSPEPP VTQRGCCSSY PPTKGGGLGP CGKCQEGLEG GASGASEPSE 
    EVNKASGPRA CPPSHHTKLK KTWLTRHSEQ FECPRGCPEV EERPVARLRA LKRAGSPEVQ 
    GAMGSPAPKR PPDPFPGTAE QGAGGWQEVR DTSIGNKDVD SGQHDEQKGP QDGQASLQDP 
    GLQDIPCLAL PAKLAQCQSC AQAAGEGGGH ACHSQQVRRS PLGGELQQEE DTATNSSSEE 
    GPGSGPDSRL STGLAKHLLS GLGDRLCRLL RREREALAWA QREGQGPAVT EDSPGIPRCC 
    SRCHHGLFNT HWRCPRCSHR LCVACGRVAG TGRAREKAGF QEQSAEECTQ EAGHAACSLM 
    LTQFVSSQAL AELSTAMHQV WVKFDIRGHC PCQADARVWA PGDAGQQKES TQKTPPTPQP 
    SCNGDTHRTK SIKEETPDSA ETPAEDRAGR GPLPCPSLCE LLASTAVKLC LGHERIHMAF 
    APVTPALPSD DRITNILDSI IAQVVERKIQ EKALGPGLRA GPGLRKGLGL PLSPVRPRLP 
    PPGALLWLQE PQPCPRRGFH LFQEHWRQGQ PVLVSGIQRT LQGNLWGTEA LGALGGQVQA 
    LSPLGPPQPS SLGSTTFWEG FSWPELRPKS DEGSVLLLHR ALGDEDTSRV ENLAASLPLP 
    EYCALHGKLN LASYLPPGLA LRPLEPQLWA AYGVSPHRGH LGTKNLCVEV ADLVSILVHA 
    DTPLPAWHRA QKDFLSGLDG EGLWSPGSQV STVWHVFRAQ DAQRIRRFLQ MVCPAGAGAL 
    EPGAPGSCYL DAGLRRRLRE EWGVSCWTLL QAPGEAVLVP AGAPHQVQGL VSTVSVTQHF 
    LSPETSALSA QLCHQGPSLP PDCHLLYAQM DWAVFQAVKV AVGTLQEAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.