ADCY10 | ENSG00000143199 | NCBI 55811

Details for: ADCY10

Gene ID: 55811

Symbol: ADCY10

Ensembl ID: ENSG00000143199

Description: adenylate cyclase 10

Associated with

Hedgehog 'off' state
(R-HSA-5610787)
Signaling by hedgehog
(R-HSA-5358351)
Signal transduction
(R-HSA-162582)
Adenylate cyclase activity
(GO:0004016)
Apical plasma membrane
(GO:0016324)
Astrocyte end-foot
(GO:0097450)
Atpase binding
(GO:0051117)
Atp binding
(GO:0005524)
Basal part of cell
(GO:0045178)
Bicarbonate binding
(GO:0071890)
Camp biosynthetic process
(GO:0006171)
Cellular response to inorganic substance
(GO:0071241)
Central region of growth cone
(GO:0090724)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Epithelial cilium movement involved in extracellular fluid movement
(GO:0003351)
Extracellular region
(GO:0005576)
Glucose catabolic process
(GO:0006007)
Intracellular signal transduction
(GO:0035556)
Magnesium ion binding
(GO:0000287)
Manganese ion binding
(GO:0030145)
Microtubule cytoskeleton
(GO:0015630)
Mitochondrial atp transmembrane transport
(GO:1990544)
Mitochondrion
(GO:0005739)
Motile cilium
(GO:0031514)
Negative regulation of cardiac muscle cell contraction
(GO:0106135)
Negative regulation of mitochondrial membrane potential
(GO:0010917)
Negative regulation of reactive oxygen species biosynthetic process
(GO:1903427)
Neuronal cell body
(GO:0043025)
Neuron projection extension
(GO:1990138)
Neuron projection maintenance
(GO:1990535)
Neuron projection retraction
(GO:0106028)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of atp biosynthetic process
(GO:2001171)
Positive regulation of axon extension
(GO:0045773)
Positive regulation of cardiac muscle cell apoptotic process
(GO:0010666)
Positive regulation of cardiac muscle hypertrophy
(GO:0010613)
Positive regulation of glycogen catabolic process
(GO:0045819)
Positive regulation of mitochondrial depolarization
(GO:0051901)
Positive regulation of ossification
(GO:0045778)
Positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
(GO:1903378)
Positive regulation of peptidyl-threonine phosphorylation
(GO:0010800)
Positive regulation of protein targeting to mitochondrion
(GO:1903955)
Positive regulation of reactive oxygen species biosynthetic process
(GO:1903428)
Positive regulation of vascular associated smooth muscle cell apoptotic process
(GO:1905461)
Regulation of membrane repolarization
(GO:0060306)
Regulation of mitophagy
(GO:1901524)
Spermatid development
(GO:0007286)

Other Information

Proteins

Adenylate cyclase type 10

Genular Protein ID: 2875531231

Symbol: ADCYA_HUMAN

Name: Adenylate cyclase type 10

UniProtKB Accession Codes:

Q96PN6 B4DZF0 F5GWS5 O95558 Q5R329 Q5R330 Q8WXV4 Q9NNX0

Database IDs:

Citations:

PubMed ID: 11423534

Title: Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase.

PubMed ID: 11423534

DOI: 10.1074/jbc.m011698200

PubMed ID: 11932268

Title: Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density.

PubMed ID: 11932268

DOI: 10.1210/jcem.87.4.8300

PubMed ID: 12609998

Title: Kinetic properties of 'soluble' adenylyl cyclase. Synergism between calcium and bicarbonate.

PubMed ID: 12609998

DOI: 10.1074/jbc.m212475200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12475901

Title: Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains.

PubMed ID: 12475901

DOI: 10.1096/fj.02-0598fje

PubMed ID: 15659711

Title: Cloning and characterization of the human soluble adenylyl cyclase.

PubMed ID: 15659711

DOI: 10.1152/ajpcell.00584.2004

PubMed ID: 17591988

Title: Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP.

PubMed ID: 17591988

DOI: 10.1085/jgp.200709784

PubMed ID: 24616449

Title: Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket.

PubMed ID: 24616449

DOI: 10.1002/cmdc.201300480

PubMed ID: 25040695

Title: Structural analysis of human soluble adenylyl cyclase and crystal structures of its nucleotide complexes-implications for cyclase catalysis and evolution.

PubMed ID: 25040695

DOI: 10.1111/febs.12913

PubMed ID: 24567411

Title: Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate.

PubMed ID: 24567411

DOI: 10.1073/pnas.1322778111

Sequence Information:

Length: 1610
Mass: 187149
Checksum: E0E205747120EFE0
Sequence:

MNTPKEEFQD WPIVRIAAHL PDLIVYGHFS PERPFMDYFD GVLMFVDISG FTAMTEKFSS 
AMYMDRGAEQ LVEILNYHIS AIVEKVLIFG GDILKFAGDA LLALWRVERK QLKNIITVVI 
KCSLEIHGLF ETQEWEEGLD IRVKIGLAAG HISMLVFGDE THSHFLVIGQ AVDDVRLAQN 
MAQMNDVILS PNCWQLCDRS MIEIESVPDQ RAVKVNFLKP PPNFNFDEFF TKCTTFMHYY 
PSGEHKNLLR LACTLKPDPE LEMSLQKYVM ESILKQIDNK QLQGYLSELR PVTIVFVNLM 
FEDQDKAEEI GPAIQDAYMH ITSVLKIFQG QINKVFMFDK GCSFLCVFGF PGEKVPDELT 
HALECAMDIF DFCSQVHKIQ TVSIGVASGI VFCGIVGHTV RHEYTVIGQK VNLAARMMMY 
YPGIVTCDSV TYNGSNLPAY FFKELPKKVM KGVADSGPLY QYWGRTEKVM FGMACLICNR 
KEDYPLLGRN KEINYFMYTM KKFLISNSSQ VLMYEGLPGY GKSQILMKIE YLAQGKNHRI 
IAISLNKISF HQTFYTIQMF MANVLGLDTC KHYKERQTNL RNKVMTLLDE KFYCLLNDIF 
HVQFPISREI SRMSTLKKQK QLEILFMKIL KLIVKEERII FIIDEAQFVD STSWRFMEKL 
IRTLPIFIIM SLCPFVNIPC AAARAVIKNR NTTYIVIGAV QPNDISNKIC LDLNVSCISK 
ELDSYLGEGS CGIPFYCEEL LKNLEHHEVL VFQQTESEEK TNRTWNNLFK YSIKLTEKLN 
MVTLHSDKES EEVCHLTSGV RLKNLSPPTS LKEISLIQLD SMRLSHQMLV RCAAIIGLTF 
TTELLFEILP CWNMKMMIKT LATLVESNIF YCFRNGKELQ KALKQNDPSF EVHYRSLSLK 
PSEGMDHGEE EQLRELENEV IECHRIRFCN PMMQKTAYEL WLKDQRKAMH LKCARFLEED 
AHRCDHCRGR DFIPYHHFTV NIRLNALDMD AIKKMAMSHG FKTEEKLILS NSEIPETSAF 
FPENRSPEEI REKILNFFDH VLTKMKTSDE DIIPLESCQC EEILEIVILP LAHHFLALGE 
NDKALYYFLE IASAYLIFCD NYMAYMYLNE GQKLLKTLKK DKSWSQTFES ATFYSLKGEV 
CFNMGQIVLA KKMLRKALKL LNRIFPYNLI SLFLHIHVEK NRHFHYVNRQ AQESPPPGKK 
RLAQLYRQTV CLSLLWRIYS YSYLFHCKYY AHLAVMMQMN TALETQNCFQ IIKAYLDYSL 
YHHLAGYKGV WFKYEVMAME HIFNLPLKGE GIEIVAYVAE TLVFNKLIMG HLDLAIELGS 
RALQMWALLQ NPNRHYQSLC RLSRCLLLNS RYPQLIQVLG RLWELSVTQE HIFSKAFFYF 
VCLDILLYSG FVYRTFEECL EFIHQYENNR ILKFHSGLLL GLYSSVAIWY ARLQEWDNFY 
KFSNRAKNLL PRRTMTLTYY DGISRYMEGQ VLHLQKQIKE QSENAQASGE ELLKNLENLV 
AQNTTGPVFC PRLYHLMAYV CILMGDGQKC GLFLNTALRL SETQGNILEK CWLNMNKESW 
YSTSELKEDQ WLQTILSLPS WEKIVAGRVN IQDLQKNKFL MRANTVDNHF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ADCY10

Associated with

Other Information

Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase. PubMed ID: 11423534

Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density. PubMed ID: 11932268

Kinetic properties of 'soluble' adenylyl cyclase. Synergism between calcium and bicarbonate. PubMed ID: 12609998

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains. PubMed ID: 12475901

Cloning and characterization of the human soluble adenylyl cyclase. PubMed ID: 15659711

Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP. PubMed ID: 17591988

Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. PubMed ID: 24616449

Structural analysis of human soluble adenylyl cyclase and crystal structures of its nucleotide complexes-implications for cyclase catalysis and evolution. PubMed ID: 25040695

Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate. PubMed ID: 24567411