Details for: VPS11

Gene ID: 55823

Symbol: VPS11

Ensembl ID: ENSG00000160695

Description: VPS11 core subunit of CORVET and HOPS complexes

Associated with

Other Information

Genular Protein ID: 233526449

Symbol: VPS11_HUMAN

Name: Vacuolar protein sorting-associated protein 11 homolog

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11250079

Title: Molecular cloning and characterization of human VPS18, VPS11, VPS16, and VPS33.

PubMed ID: 11250079

DOI: 10.1016/s0378-1119(01)00333-x

PubMed ID: 11382755

Title: Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7.

PubMed ID: 11382755

DOI: 10.1074/jbc.m101778200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17897319

Title: Integral and associated lysosomal membrane proteins.

PubMed ID: 17897319

DOI: 10.1111/j.1600-0854.2007.00643.x

PubMed ID: 20682791

Title: A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.

PubMed ID: 20682791

DOI: 10.1074/jbc.m110.154120

PubMed ID: 20434987

Title: Identification of the switch in early-to-late endosome transition.

PubMed ID: 20434987

DOI: 10.1016/j.cell.2010.03.011

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21802320

Title: Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b.

PubMed ID: 21802320

DOI: 10.1016/j.immuni.2011.06.009

PubMed ID: 21148287

Title: The ERM proteins interact with the HOPS complex to regulate the maturation of endosomes.

PubMed ID: 21148287

DOI: 10.1091/mbc.e10-09-0796

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23351085

Title: Tethering complexes in the endocytic pathway: CORVET and HOPS.

PubMed ID: 23351085

DOI: 10.1111/febs.12151

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23901104

Title: Structural basis of Vps33A recruitment to the human HOPS complex by Vps16.

PubMed ID: 23901104

DOI: 10.1073/pnas.1307074110

PubMed ID: 23593995

Title: The ERM proteins ezrin and moesin regulate retrograde Shiga toxin transport.

PubMed ID: 23593995

DOI: 10.1111/tra.12077

PubMed ID: 24554770

Title: The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17.

PubMed ID: 24554770

DOI: 10.1091/mbc.e13-08-0447

PubMed ID: 25266290

Title: Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations.

PubMed ID: 25266290

DOI: 10.1111/tra.12232

PubMed ID: 25783203

Title: Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes.

PubMed ID: 25783203

DOI: 10.1111/tra.12283

PubMed ID: 28325809

Title: The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes.

PubMed ID: 28325809

DOI: 10.1083/jcb.201607085

PubMed ID: 26307567

Title: Hypomyelination and developmental delay associated with VPS11 mutation in Ashkenazi-Jewish patients.

PubMed ID: 26307567

DOI: 10.1136/jmedgenet-2015-103239

PubMed ID: 33452836

Title: A Novel Homozygous VPS11 Variant May Cause Generalized Dystonia.

PubMed ID: 33452836

DOI: 10.1002/ana.26021

Sequence Information:

  • Length: 941
  • Mass: 107837
  • Checksum: C1F8E538ED1B56DB
  • Sequence:
  • MAAYLQWRRF VFFDKELVKE PLSNDGAAPG ATPASGSAAS KFLCLPPGIT VCDSGRGSLV 
    FGDMEGQIWF LPRSLQLTGF QAYKLRVTHL YQLKQHNILA SVGEDEEGIN PLVKIWNLEK 
    RDGGNPLCTR IFPAIPGTEP TVVSCLTVHE NLNFMAIGFT DGSVTLNKGD ITRDRHSKTQ 
    ILHKGNYPVT GLAFRQAGKT THLFVVTTEN VQSYIVSGKD YPRVELDTHG CGLRCSALSD 
    PSQDLQFIVA GDECVYLYQP DERGPCFAFE GHKLIAHWFR GYLIIVSRDR KVSPKSEFTS 
    RDSQSSDKQI LNIYDLCNKF IAYSTVFEDV VDVLAEWGSL YVLTRDGRVH ALQEKDTQTK 
    LEMLFKKNLF EMAINLAKSQ HLDSDGLAQI FMQYGDHLYS KGNHDGAVQQ YIRTIGKLEP 
    SYVIRKFLDA QRIHNLTAYL QTLHRQSLAN ADHTTLLLNC YTKLKDSSKL EEFIKKKSES 
    EVHFDVETAI KVLRQAGYYS HALYLAENHA HHEWYLKIQL EDIKNYQEAL RYIGKLPFEQ 
    AESNMKRYGK ILMHHIPEQT TQLLKGLCTD YRPSLEGRSD REAPGCRANS EEFIPIFANN 
    PRELKAFLEH MSEVQPDSPQ GIYDTLLELR LQNWAHEKDP QVKEKLHAEA ISLLKSGRFC 
    DVFDKALVLC QMHDFQDGVL YLYEQGKLFQ QIMHYHMQHE QYRQVISVCE RHGEQDPSLW 
    EQALSYFARK EEDCKEYVAA VLKHIENKNL MPPLLVVQTL AHNSTATLSV IRDYLVQKLQ 
    KQSQQIAQDE LRVRRYREET TRIRQEIQEL KASPKIFQKT KCSICNSALE LPSVHFLCGH 
    SFHQHCFESY SESDADCPTC LPENRKVMDM IRAQEQKRDL HDQFQHQLRC SNDSFSVIAD 
    YFGRGVFNKL TLLTDPPTAR LTSSLEAGLQ RDLLMHSRRG T

Genular Protein ID: 3009115460

Symbol: A0A087WXL6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 941
  • Mass: 107809
  • Checksum: 58F8E538FE86E013
  • Sequence:
  • MAAYLQWRRF VFFDKELVKE PLSNDGAAPG ATPASGSAAS KFLCLPPGIT VCDSGRGSLV 
    FGDMEGQIWF LPRSLQLTGF QAYKLRVTHL YQLKQHNILA SVGEDEEGIN PLVKIWNLEK 
    RDGGNPLCTR IFPAIPGTEP TVVSCLTVHE NLNFMAIGFT DGSVTLNKGD ITRDRHSKTQ 
    ILHKGNYPVT GLAFRQAGKT THLFVVTTEN VQSYIVSGKD YPRVELDTHG CGLRCSALSD 
    PSQDLQFIVA GDECVYLYQP DERGPCFAFE GHKLIAHWFR GYLIIVSRDR KVSPKSEFTS 
    RDSQSSDKQI LNIYDLCNKF IAYSTVFEDV VDVLAEWGSL YVLTRDGRVH ALQEKDTQTK 
    LEMLFKKNLF EMAINLAKSQ HLDSDGLAQI FMQYGDHLYS KGNHDGAVQQ YIRTIGKLEP 
    SYVIRKFLDA QRIHNLTAYL QTLHRQSLAN ADHTTLLLNC YTKLKDSSKL EEFIKKKSES 
    EVHFDVETAI KVLRQAGYYS HALYLAENHA HHEWYLKIQL EDIKNYQEAL RYIGKLPFEQ 
    AESNMKRYGK ILMHHIPEQT TQLLKGLCTD YRPSLEGRSD REAPGCRANS EEFIPIFANN 
    PRELKAFLEH MSEVQPDSPQ GIYDTLLELR LQNWAHEKDP QVKEKLHAEA ISLLKSGRFC 
    DVFDKALVLC QMHDFQDGVL YLYEQGKLFQ QIMHYHMQHE QYRQVISVCE RHGEQDPSLW 
    EQALSYFARK EEDCKEYVAA VLKHIENKNL MPPLLVVQTL AHNSTATLSV IRDYLVQKLQ 
    KQSQQIAQDE LRVRRYREET TRIRQEIQEL KASPKIFQKT KCSICNSALE LPSVHFLCGH 
    SFHQHCFESY SESDADCPTC LPENRKVMDM IRAQEQKRDL HDQFQHQLKC SNDSFSVIAD 
    YFGRGVFNKL TLLTDPPTAR LTSSLEAGLQ RDLLMHSRRG T

Genular Protein ID: 4223177379

Symbol: B7Z879_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 931
  • Mass: 107375
  • Checksum: 932001ABEAD0EBC9
  • Sequence:
  • MKSVCRRGPC RAPLWFSWSS RVVLWSTGRK KEVHLLTCYQ LSNPGRLLDY PAHMEGQIWF 
    LPRSLQLTGF QAYKLRVTHL YQLKQHNILA SVGEDEEGIN PLVKIWNLEK RDGGNPLCTR 
    IFPAIPGTEP TVVSCLTVHE NLNFMAIGFT DGSVTLNKGD ITRDRHSKTQ ILHKGNYPVT 
    GLAFRQAGKT THLFVVTTEN VQSYIVSGKD YPRVELDTHG CGLRCSALSD PSQDLQFIVA 
    GDECVYLYQP DERGPCFAFE GHKLIAHWFR GYLIIVSRDR KVSPKSEFTS RDSQSSDKQI 
    LNIYDLCNKF IAYSTVFEDV VDVLAEWGSL YVLTRDGRVH ALQEKDTQTK LEMLFKKNLF 
    EMAINLAKSQ HLDSDGLAQI FMQYGDHLYS KGNHDGAVQQ YIRTIGKLEP SYVIRKFLDA 
    QRIHNLTAYL QTLHRQSLAN ADHTTLLLNC YTKLKDSSKL EEFIKKKSES EVHFDVETAI 
    KVLRQAGYYS HALYLAENHA HHEWYLKIQL EDIKNYQEAL RYIGKLPFEQ AESNMKRYGK 
    ILMHHIPEQT TQLLKGLCTD YRPSLEGRSD REAPGCRANS EEFIPIFANN PRELKAFLEH 
    MSEVQPDSPQ GIYDTLLELR LQNWAHEKDP QVKEKLHAEA ISLLKSGRFC DVFDKALVLC 
    QMHDFQDGVL YLYEQGKLFQ QIMHYHMQHE QYRQVISVCE RHGEQDPSLW EQALSYFARK 
    EEDCKEYVAA VLKHIENKNL MPPLLVVQTL AHNSTATLSV IRDYLVQKLQ KQSQQIAQDE 
    LRVRRYREET TRIRQEIQEL KASPKIFQKT KCSICNSALE LPSVHFLCGH SFHQHCFESY 
    SESDADCPTC LPENRKVMDM IRAQEQKRDL HDQFQHQLKC SNDSFSVIAD YFGRGVFNKL 
    TLLTDPPTAR LTSSLEAGLQ RDLLMHSRRG T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.