Details for: EAF2

Gene ID: 55840

Symbol: EAF2

Ensembl ID: ENSG00000145088

Description: ELL associated factor 2

Associated with

  • Formation of rna pol ii elongation complex
    (R-HSA-112382)
  • Gene expression (transcription)
    (R-HSA-74160)
  • Rna polymerase ii pre-transcription events
    (R-HSA-674695)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Rna polymerase ii transcription elongation
    (R-HSA-75955)
  • Apoptotic process
    (GO:0006915)
  • Epithelial cell proliferation involved in prostate gland development
    (GO:0060767)
  • Negative regulation of cell growth
    (GO:0030308)
  • Negative regulation of epithelial cell proliferation involved in prostate gland development
    (GO:0060770)
  • Nuclear speck
    (GO:0016607)
  • Nucleoplasm
    (GO:0005654)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription elongation by rna polymerase ii
    (GO:0034243)
  • Super elongation complex
    (GO:0032783)
  • Transcription elongation by rna polymerase ii
    (GO:0006368)
  • Transcription elongation factor activity
    (GO:0003711)
  • Transcription elongation factor complex
    (GO:0008023)

Other Information

Genular Protein ID: 218584077

Symbol: EAF2_HUMAN

Name: ELL-associated factor 2

UniProtKB Accession Codes:

Q96CJ1 Q9NZ82

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 12 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 4 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12446457

Title: ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties.

PubMed ID: 12446457

DOI: 10.1182/blood-2002-06-1664

PubMed ID: 12907652

Title: Suppression of prostate tumor growth by U19, a novel testosterone-regulated apoptosis inducer.

PubMed ID: 12907652

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16006523

Title: ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL.

PubMed ID: 16006523

DOI: 10.1073/pnas.0503017102

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 22195968

Title: The little elongation complex regulates small nuclear RNA transcription.

PubMed ID: 22195968

DOI: 10.1016/j.molcel.2011.12.008

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 260
  • Mass: 28792
  • Checksum: 2CDCE96FA387C799
  • Sequence:
    • MNSAAGFSHL DRRERVLKLG ESFEKQPRCA FHTVRYDFKP ASIDTSSEGY LEVGEGEQVT 
ITLPNIEGST PPVTVFKGSK KPYLKECILI INHDTGECRL EKLSSNITVK KTRVEGSSKI 
QYRKEQQQQQ MWNSARTPNL VKHSPSEDKM SPASPIDDIE RELKAEASLM DQMSSCDSSS 
DSKSSSSSSS EDSSSDSEDE DCKSSTSDTG NCVSGHPTMT QYRIPDIDAS HNRFRDNSGL 
LMNTLRNDLQ LSESGSDSDD

Genular Protein ID: 4009221174

Symbol: B4DWJ3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DWJ3

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 EPD 1 Ensembl 2 GO 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 263
  • Mass: 29172
  • Checksum: 54856ADE4420FCE8
  • Sequence:
    • MNSAAGFSHL DRRERVLKLG ESFEKQPRCA FHTVRYDFKP ASIDTSSEGY LEVGEGEQVT 
ITLPNIEGST PPVTVFKGSK KPYLKECILI INHDTGECRL EKLSSNITVK KTRVEGSSKI 
QYRKEQQQQQ MWNSARTPNL VKHSPSEDKM SPASPIDDIE RELKAEASLM DQMSSCDSSS 
DSKSSSSSSS EDSSSDSEDE DCKSSTSDTG NCVSGHPTMT QYRIPDIDAS HNRFRDNSGL 
LMNTLNNLSS HSFSSLYDPL LSH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.