BRK1 | ENSG00000254999 | NCBI 55845

Details for: BRK1

Gene ID: 55845

Symbol: BRK1

Ensembl ID: ENSG00000254999

Description: BRICK1 subunit of SCAR/WAVE actin nucleating complex

Associated with

Disease
(R-HSA-1643685)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Rac1 gtpase cycle
(R-HSA-9013149)
Rac2 gtpase cycle
(R-HSA-9013404)
Rac3 gtpase cycle
(R-HSA-9013423)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Rho gtpase cycle
(R-HSA-9012999)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate wasps and waves
(R-HSA-5663213)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Actin filament organization
(GO:0007015)
Cell motility
(GO:0048870)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Fibroblast proliferation
(GO:0048144)
Identical protein binding
(GO:0042802)
In utero embryonic development
(GO:0001701)
Lamellipodium
(GO:0030027)
Positive regulation of arp2/3 complex-mediated actin nucleation
(GO:2000601)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of lamellipodium assembly
(GO:0010592)
Positive regulation of protein-containing complex assembly
(GO:0031334)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Rac protein signal transduction
(GO:0016601)
Regulation of actin polymerization or depolymerization
(GO:0008064)
Scar complex
(GO:0031209)
Small gtpase binding
(GO:0031267)

Other Information

Proteins

Protein BRICK1

Genular Protein ID: 4065500836

Symbol: BRK1_HUMAN

Name: Protein BRICK1

UniProtKB Accession Codes:

Q8WUW1 B2R5E2 Q9P082

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15070726

Title: Purification and architecture of the ubiquitous Wave complex.

PubMed ID: 15070726

DOI: 10.1073/pnas.0400628101

PubMed ID: 18560548

Title: Free Brick1 is a trimeric precursor in the assembly of a functional wave complex.

PubMed ID: 18560548

DOI: 10.1371/journal.pone.0002462

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 21107423

Title: Structure and control of the actin regulatory WAVE complex.

PubMed ID: 21107423

DOI: 10.1038/nature09623

Sequence Information:

Length: 75
Mass: 8745
Checksum: 637B5461A2D96587
Sequence:

MAGQEDPVQR EIHQDWANRE YIEIITSSIK KIADFLNSFD MSCRSRLATL NEKLTALERR 
IEYIEARVTK GETLT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BRK1

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Purification and architecture of the ubiquitous Wave complex. PubMed ID: 15070726

Free Brick1 is a trimeric precursor in the assembly of a functional wave complex. PubMed ID: 18560548

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Structure and control of the actin regulatory WAVE complex. PubMed ID: 21107423