PSENEN | ENSG00000205155 | NCBI 55851

Details for: PSENEN

Gene ID: 55851

Symbol: PSENEN

Ensembl ID: ENSG00000205155

Description: presenilin enhancer, gamma-secretase subunit

Associated with

Activated notch1 transmits signal to the nucleus
(R-HSA-2122948)
Amyloid fiber formation
(R-HSA-977225)
Axon guidance
(R-HSA-422475)
Cell death signalling via nrage, nrif and nade
(R-HSA-204998)
Constitutive signaling by notch1 hd+pest domain mutants
(R-HSA-2894862)
Constitutive signaling by notch1 pest domain mutants
(R-HSA-2644606)
Death receptor signaling
(R-HSA-73887)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Eph-ephrin mediated repulsion of cells
(R-HSA-3928665)
Eph-ephrin signaling
(R-HSA-2682334)
Metabolism of proteins
(R-HSA-392499)
Nervous system development
(R-HSA-9675108)
Noncanonical activation of notch3
(R-HSA-9017802)
Notch2 activation and transmission of signal to the nucleus
(R-HSA-2979096)
Notch3 activation and transmission of signal to the nucleus
(R-HSA-9013507)
Notch4 activation and transmission of signal to the nucleus
(R-HSA-9013700)
Nrif signals cell death from the nucleus
(R-HSA-205043)
Nuclear signaling by erbb4
(R-HSA-1251985)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
Regulated proteolysis of p75ntr
(R-HSA-193692)
Signaling by erbb4
(R-HSA-1236394)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 hd+pest domain mutants in cancer
(R-HSA-2894858)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch1 pest domain mutants in cancer
(R-HSA-2644602)
Signaling by notch2
(R-HSA-1980145)
Signaling by notch3
(R-HSA-9012852)
Signaling by notch4
(R-HSA-9013694)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Amyloid-beta formation
(GO:0034205)
Amyloid precursor protein catabolic process
(GO:0042987)
Amyloid precursor protein metabolic process
(GO:0042982)
Endopeptidase activator activity
(GO:0061133)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Endosome membrane
(GO:0010008)
Enzyme binding
(GO:0019899)
Gamma-secretase complex
(GO:0070765)
Golgi apparatus
(GO:0005794)
Golgi cisterna membrane
(GO:0032580)
Golgi membrane
(GO:0000139)
Membrane
(GO:0016020)
Membrane protein ectodomain proteolysis
(GO:0006509)
Membrane protein intracellular domain proteolysis
(GO:0031293)
Notch receptor processing
(GO:0007220)
Notch signaling pathway
(GO:0007219)
Plasma membrane
(GO:0005886)
Positive regulation of catalytic activity
(GO:0043085)
Positive regulation of endopeptidase activity
(GO:0010950)
Presynaptic membrane
(GO:0042734)
Protein binding
(GO:0005515)
Protein processing
(GO:0016485)

Other Information

Proteins

Gamma-secretase subunit PEN-2

Genular Protein ID: 2733677438

Symbol: PEN2_HUMAN

Name: Gamma-secretase subunit PEN-2

UniProtKB Accession Codes:

Q9NZ42 B2R5L9

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12198112

Title: PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin.

PubMed ID: 12198112

DOI: 10.1074/jbc.c200469200

PubMed ID: 12110170

Title: aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.

PubMed ID: 12110170

DOI: 10.1016/s1534-5807(02)00189-2

PubMed ID: 12522139

Title: PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

PubMed ID: 12522139

DOI: 10.1074/jbc.c200648200

PubMed ID: 12639958

Title: Membrane topology of gamma-secretase component PEN-2.

PubMed ID: 12639958

DOI: 10.1074/jbc.m213107200

PubMed ID: 12763021

Title: APH1, PEN2, and nicastrin increase Abeta levels and gamma-secretase activity.

PubMed ID: 12763021

DOI: 10.1016/s0006-291x(03)00797-6

PubMed ID: 12740439

Title: Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.

PubMed ID: 12740439

DOI: 10.1073/pnas.1037392100

PubMed ID: 12679784

Title: Reconstitution of gamma-secretase activity.

PubMed ID: 12679784

DOI: 10.1038/ncb960

PubMed ID: 20929727

Title: Gamma-secretase gene mutations in familial acne inversa.

PubMed ID: 20929727

DOI: 10.1126/science.1196284

PubMed ID: 24941111

Title: Pen-2 is essential for gamma-secretase complex stability and trafficking but partially dispensable for endoproteolysis.

PubMed ID: 24941111

DOI: 10.1021/bi500489j

PubMed ID: 25043039

Title: Three-dimensional structure of human gamma-secretase.

PubMed ID: 25043039

DOI: 10.1038/nature13567

PubMed ID: 26623517

Title: Sampling the conformational space of the catalytic subunit of human gamma-secretase.

PubMed ID: 26623517

DOI: 10.7554/elife.11182

PubMed ID: 26280335

Title: An atomic structure of human gamma-secretase.

PubMed ID: 26280335

DOI: 10.1038/nature14892

PubMed ID: 30598546

Title: Structural basis of Notch recognition by human gamma-secretase.

PubMed ID: 30598546

DOI: 10.1038/s41586-018-0813-8

PubMed ID: 30630874

Title: Recognition of the amyloid precursor protein by human gamma-secretase.

PubMed ID: 30630874

DOI: 10.1126/science.aaw0930

Sequence Information:

Length: 101
Mass: 12029
Checksum: FDBA4D299488EA02
Sequence:

MNLERVSNEE KLNLCRKYYL GGFAFLPFLW LVNIFWFFRE AFLVPAYTEQ SQIKGYVWRS 
AVGFLFWVIV LTSWITIFQI YRPRWGALGD YLSFTIPLGT P

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSENEN

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin. PubMed ID: 12198112

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. PubMed ID: 12110170

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1. PubMed ID: 12522139

Membrane topology of gamma-secretase component PEN-2. PubMed ID: 12639958

APH1, PEN2, and nicastrin increase Abeta levels and gamma-secretase activity. PubMed ID: 12763021

Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. PubMed ID: 12740439

Reconstitution of gamma-secretase activity. PubMed ID: 12679784

Gamma-secretase gene mutations in familial acne inversa. PubMed ID: 20929727

Pen-2 is essential for gamma-secretase complex stability and trafficking but partially dispensable for endoproteolysis. PubMed ID: 24941111

Three-dimensional structure of human gamma-secretase. PubMed ID: 25043039

Sampling the conformational space of the catalytic subunit of human gamma-secretase. PubMed ID: 26623517

An atomic structure of human gamma-secretase. PubMed ID: 26280335

Structural basis of Notch recognition by human gamma-secretase. PubMed ID: 30598546

Recognition of the amyloid precursor protein by human gamma-secretase. PubMed ID: 30630874