HDAC8 | ENSG00000147099 | NCBI 55869

Details for: HDAC8

Gene ID: 55869

Symbol: HDAC8

Ensembl ID: ENSG00000147099

Description: histone deacetylase 8

Associated with

Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Chromatin modifying enzymes
(R-HSA-3247509)
Constitutive signaling by notch1 hd+pest domain mutants
(R-HSA-2894862)
Constitutive signaling by notch1 pest domain mutants
(R-HSA-2644606)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hdacs deacetylate histones
(R-HSA-3214815)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
M phase
(R-HSA-68886)
Notch-hlh transcription pathway
(R-HSA-350054)
Notch1 intracellular domain regulates transcription
(R-HSA-2122947)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rna polymerase ii transcription
(R-HSA-73857)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 hd+pest domain mutants in cancer
(R-HSA-2894858)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch1 pest domain mutants in cancer
(R-HSA-2644602)
Signal transduction
(R-HSA-162582)
Chromatin organization
(GO:0006325)
Chromatin remodeling
(GO:0006338)
Cytoplasm
(GO:0005737)
Dna-binding transcription factor binding
(GO:0140297)
Histone deacetylase activity
(GO:0004407)
Histone deacetylase complex
(GO:0000118)
Histone decrotonylase activity
(GO:0160009)
Hsp70 protein binding
(GO:0030544)
Hsp90 protein binding
(GO:0051879)
Metal ion binding
(GO:0046872)
Mitotic sister chromatid cohesion
(GO:0007064)
Negative regulation of protein ubiquitination
(GO:0031397)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear chromosome
(GO:0000228)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein lysine deacetylase activity
(GO:0033558)
Regulation of protein stability
(GO:0031647)
Regulation of telomere maintenance
(GO:0032204)

Other Information

Proteins

Protein deacetylase HDAC8

Genular Protein ID: 3452585968

Symbol: HDAC8_HUMAN

Name: Protein deacetylase HDAC8

UniProtKB Accession Codes:

Q9BY41 A6ND12 A6ND61 A6NET3 A6NJR3 A8MQ62 B4DKN0 B4DV22 Q86VC8 Q9NP76 Q9NYH4

Database IDs:

Citations:

PubMed ID: 10748112

Title: Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor.

PubMed ID: 10748112

DOI: 10.1074/jbc.m908988199

PubMed ID: 10926844

Title: Cloning and characterization of a novel human histone deacetylase, HDAC8.

PubMed ID: 10926844

DOI: 10.1042/bj3500199

PubMed ID: 10922473

Title: Cloning and characterization of human histone deacetylase 8.

PubMed ID: 10922473

DOI: 10.1016/s0014-5793(00)01813-5

PubMed ID: 8889548

Title: Normalization and subtraction: two approaches to facilitate gene discovery.

PubMed ID: 8889548

DOI: 10.1101/gr.6.9.791

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10756090

Title: Characterization of a highly complex region in Xq13 and mapping of three isodicentric breakpoints associated with preleukemia.

PubMed ID: 10756090

DOI: 10.1006/geno.2000.6128

PubMed ID: 11533236

Title: ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.

PubMed ID: 11533236

DOI: 10.1128/mcb.21.19.6470-6483.2001

PubMed ID: 12509458

Title: The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain.

PubMed ID: 12509458

DOI: 10.1128/mcb.23.2.607-619.2003

PubMed ID: 14701748

Title: Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A.

PubMed ID: 14701748

DOI: 10.1128/mcb.24.2.765-773.2004

PubMed ID: 15772115

Title: Histone deacetylase HDAC8 associates with smooth muscle alpha-actin and is essential for smooth muscle cell contractility.

PubMed ID: 15772115

DOI: 10.1096/fj.04-2303fje

PubMed ID: 16538051

Title: Use of histone deacetylase 8 (HDAC8), a new marker of smooth muscle differentiation, in the classification of mesenchymal tumors of the uterus.

PubMed ID: 16538051

DOI: 10.1097/01.pas.0000188029.63706.31

PubMed ID: 16809764

Title: Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation.

PubMed ID: 16809764

DOI: 10.1128/mcb.01971-05

PubMed ID: 22889856

Title: X-exome sequencing identifies a HDAC8 variant in a large pedigree with X-linked intellectual disability, truncal obesity, gynaecomastia, hypogonadism and unusual face.

PubMed ID: 22889856

DOI: 10.1136/jmedgenet-2012-100921

PubMed ID: 22885700

Title: HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle.

PubMed ID: 22885700

DOI: 10.1038/nature11316

PubMed ID: 28497810

Title: Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription.

PubMed ID: 28497810

DOI: 10.1038/cr.2017.68

PubMed ID: 15242608

Title: Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases.

PubMed ID: 15242608

DOI: 10.1016/j.str.2004.04.012

PubMed ID: 17721440

Title: Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex.

PubMed ID: 17721440

DOI: 10.1038/sj.embor.7401047

PubMed ID: 19053282

Title: Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.

PubMed ID: 19053282

DOI: 10.1021/bi801610c

Sequence Information:

Length: 377
Mass: 41758
Checksum: CAA1B91894FB5013
Sequence:

MEEPEEPADS GQSLVPVYIY SPEYVSMCDS LAKIPKRASM VHSLIEAYAL HKQMRIVKPK 
VASMEEMATF HTDAYLQHLQ KVSQEGDDDH PDSIEYGLGY DCPATEGIFD YAAAIGGATI 
TAAQCLIDGM CKVAINWSGG WHHAKKDEAS GFCYLNDAVL GILRLRRKFE RILYVDLDLH 
HGDGVEDAFS FTSKVMTVSL HKFSPGFFPG TGDVSDVGLG KGRYYSVNVP IQDGIQDEKY 
YQICESVLKE VYQAFNPKAV VLQLGADTIA GDPMCSFNMT PVGIGKCLKY ILQWQLATLI 
LGGGGYNLAN TARCWTYLTG VILGKTLSSE IPDHEFFTAY GPDYVLEITP SCRPDRNEPH 
RIQQILNYIK GNLKHVV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: HDAC8

Associated with

Other Information

Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor. PubMed ID: 10748112

Cloning and characterization of a novel human histone deacetylase, HDAC8. PubMed ID: 10926844

Cloning and characterization of human histone deacetylase 8. PubMed ID: 10922473

Normalization and subtraction: two approaches to facilitate gene discovery. PubMed ID: 8889548

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of the human X chromosome. PubMed ID: 15772651

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of a highly complex region in Xq13 and mapping of three isodicentric breakpoints associated with preleukemia. PubMed ID: 10756090

ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. PubMed ID: 11533236

The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain. PubMed ID: 12509458

Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A. PubMed ID: 14701748

Histone deacetylase HDAC8 associates with smooth muscle alpha-actin and is essential for smooth muscle cell contractility. PubMed ID: 15772115

Use of histone deacetylase 8 (HDAC8), a new marker of smooth muscle differentiation, in the classification of mesenchymal tumors of the uterus. PubMed ID: 16538051

Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation. PubMed ID: 16809764

X-exome sequencing identifies a HDAC8 variant in a large pedigree with X-linked intellectual disability, truncal obesity, gynaecomastia, hypogonadism and unusual face. PubMed ID: 22889856

HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle. PubMed ID: 22885700

Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription. PubMed ID: 28497810

Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases. PubMed ID: 15242608

Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex. PubMed ID: 17721440

Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. PubMed ID: 19053282