Details for: GSDMB

Gene ID: 55876

Symbol: GSDMB

Ensembl ID: ENSG00000073605

Description: gasdermin B

Associated with

Other Information

Genular Protein ID: 729169132

Symbol: GSDMB_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8TAX9 B4DKK7 Q7Z377 Q8WY76 Q9NX71 Q9P163

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 4 Ensembl 6 ExpressionAtlas 1 GO 14 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 10 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 RNAct 1 RefSeq 7 SAM 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11483580

Title: Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs.

PubMed ID: 11483580

DOI: 10.1101/gr.175501

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 32299851

Title: Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells.

PubMed ID: 32299851

DOI: 10.1126/science.aaz7548

PubMed ID: 16625320

Title: Transcriptional control of the HERV-H LTR element of the GSDML gene in human tissues and cancer cells.

PubMed ID: 16625320

DOI: 10.1007/s00705-006-0764-5

PubMed ID: 17391312

Title: Identification of a predictive gene expression signature of cervical lymph node metastasis in oral squamous cell carcinoma.

PubMed ID: 17391312

DOI: 10.1111/j.1349-7006.2007.00454.x

PubMed ID: 17350798

Title: Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner.

PubMed ID: 17350798

DOI: 10.1016/j.ygeno.2007.01.003

PubMed ID: 18038310

Title: Differential expression and localisation of gasdermin-like (GSDML), a novel member of the cancer-associated GSDMDC protein family, in neoplastic and non-neoplastic gastric, hepatic, and colon tissues.

PubMed ID: 18038310

DOI: 10.1080/00313020701716250

PubMed ID: 19051310

Title: Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium.

PubMed ID: 19051310

DOI: 10.1002/gcc.20636

PubMed ID: 27281216

Title: Pore-forming activity and structural autoinhibition of the gasdermin family.

PubMed ID: 27281216

DOI: 10.1038/nature18590

PubMed ID: 34022140

Title: Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions.

PubMed ID: 34022140

DOI: 10.1016/j.cell.2021.04.036

PubMed ID: 35021065

Title: GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis.

PubMed ID: 35021065

DOI: 10.1016/j.cell.2021.12.024

PubMed ID: 36157507

Title: GSDMB N-terminal assembles in plasma membrane to execute pyroptotic cell death.

PubMed ID: 36157507

DOI: 10.1016/j.gendis.2021.12.022

PubMed ID: 36899106

Title: Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells.

PubMed ID: 36899106

DOI: 10.1038/s41418-023-01143-y

PubMed ID: 28154144

Title: Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein.

PubMed ID: 28154144

DOI: 10.1073/pnas.1616783114

PubMed ID: 36991122

Title: Structural basis for GSDMB pore formation and its targeting by IpaH7.8.

PubMed ID: 36991122

DOI: 10.1038/s41586-023-05832-z

PubMed ID: 36991125

Title: Structural mechanisms for regulation of GSDMB pore-forming activity.

PubMed ID: 36991125

DOI: 10.1038/s41586-023-05872-5

PubMed ID: 36599845

Title: Insights into the GSDMB-mediated cellular lysis and its targeting by IpaH7.8.

PubMed ID: 36599845

DOI: 10.1038/s41467-022-35725-0

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 416
  • Mass: 47348
  • Checksum: 04DDA43952EF603F
  • Sequence:
    • MFSVFEEITR IVVKEMDAGG DMIAVRSLVD ADRFRCFHLV GEKRTFFGCR HYTTGLTLMD 
ILDTDGDKWL DELDSGLQGQ KAEFQILDNV DSTGELIVRL PKEITISGSF QGFHHQKIKI 
SENRISQQYL ATLENRKLKR ELPFSFRSIN TRENLYLVTE TLETVKEETL KSDRQYKFWS 
QISQGHLSYK HKGQREVTIP PNRVLSYRVK QLVFPNKETM NIHFRGKTKS FPEEKDGASS 
CLGKSLGSED SRNMKEKLED MESVLKDLTE EKRKDVLNSL AKCLGKEDIR QDLEQRVSEV 
LISGELHMED PDKPLLSSLF NAAGVLVEAR AKAILDFLDA LLELSEEQQF VAEALEKGTL 
PLLKDQVKSV MEQNWDELAS SPPDMDYDPE ARILCALYVV VSILLELAEG PTSVSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.