RCC2 | ENSG00000179051 | NCBI 55920

Details for: RCC2

Gene ID: 55920

Symbol: RCC2

Ensembl ID: ENSG00000179051

Description: regulator of chromosome condensation 2

Associated with

Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Cell cycle
(GO:0007049)
Cell division
(GO:0051301)
Chromosome, centromeric core domain
(GO:0034506)
Chromosome passenger complex localization to kinetochore
(GO:0072356)
Cytosol
(GO:0005829)
Early endosome membrane
(GO:0031901)
Establishment of protein localization
(GO:0045184)
Focal adhesion assembly
(GO:0048041)
Guanyl-nucleotide exchange factor activity
(GO:0005085)
Integrin-mediated signaling pathway
(GO:0007229)
Membrane
(GO:0016020)
Microtubule
(GO:0005874)
Microtubule binding
(GO:0008017)
Midbody
(GO:0030496)
Mitotic spindle midzone
(GO:1990023)
Negative regulation of focal adhesion assembly
(GO:0051895)
Negative regulation of gtpase activity
(GO:0034260)
Negative regulation of substrate adhesion-dependent cell spreading
(GO:1900025)
Nucleolus
(GO:0005730)
Plasma membrane
(GO:0005886)
Positive regulation of attachment of spindle microtubules to kinetochore
(GO:0051987)
Positive regulation of g2/m transition of mitotic cell cycle
(GO:0010971)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase binding
(GO:0019901)
Regulation of cell migration
(GO:0030334)
Regulation of fibroblast migration
(GO:0010762)
Regulation of ruffle assembly
(GO:1900027)
Rna binding
(GO:0003723)
Small gtpase binding
(GO:0031267)

Other Information

Proteins

Protein RCC2

Genular Protein ID: 3085497786

Symbol: RCC2_HUMAN

Name: Protein RCC2

UniProtKB Accession Codes:

Q9P258 Q8IVL9 Q9BSN6 Q9NPV8

Database IDs:

Citations:

PubMed ID: 12919680

Title: The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression.

PubMed ID: 12919680

DOI: 10.1016/s1534-5807(03)00205-3

PubMed ID: 10819331

Title: Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10819331

DOI: 10.1093/dnares/7.2.143

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 1939370

Title: Telophase disc: a new mammalian mitotic organelle that bisects telophase cells with a possible function in cytokinesis.

PubMed ID: 1939370

DOI: 10.1242/jcs.99.3.523

PubMed ID: 7559776

Title: Delay of HeLa cell cleavage into interphase using dihydrocytochalasin B: retention of a postmitotic spindle and telophase disc correlates with synchronous cleavage recovery.

PubMed ID: 7559776

DOI: 10.1083/jcb.131.1.191

PubMed ID: 9914378

Title: Colocalization of TD-60 and INCENP throughout G2 and mitosis: evidence for their possible interaction in signalling cytokinesis.

PubMed ID: 9914378

DOI: 10.1007/s004120050330

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23388455

Title: TD-60 is required for interphase cell cycle progression.

PubMed ID: 23388455

DOI: 10.4161/cc.23821

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25074804

Title: Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure.

PubMed ID: 25074804

DOI: 10.1242/jcs.154864

PubMed ID: 26158537

Title: TD-60 links RalA GTPase function to the CPC in mitosis.

PubMed ID: 26158537

DOI: 10.1038/ncomms8678

PubMed ID: 28869598

Title: RCC2 is a novel p53 target in suppressing metastasis.

PubMed ID: 28869598

DOI: 10.1038/onc.2017.306

Sequence Information:

Length: 522
Mass: 56085
Checksum: 7065F70AEA98EDC3
Sequence:

MPRKKAAAAA WEEPSSGNGT ARAGPRKRGG PAGRKRERPE RCSSSSGGGS SGDEDGLELD 
GAPGGGKRAA RPATAGKAGG AAVVITEPEH TKERVKLEGS KCKGQLLIFG ATNWDLIGRK 
EVPKQQAAYR NLGQNLWGPH RYGCLAGVRV RTVVSGSCAA HSLLITTEGK LWSWGRNEKG 
QLGHGDTKRV EAPRLIEGLS HEVIVSAACG RNHTLALTET GSVFAFGENK MGQLGLGNQT 
DAVPSPAQIM YNGQPITKMA CGAEFSMIMD CKGNLYSFGC PEYGQLGHNS DGKFIARAQR 
IEYDCELVPR RVAIFIEKTK DGQILPVPNV VVRDVACGAN HTLVLDSQKR VFSWGFGGYG 
RLGHAEQKDE MVPRLVKLFD FPGRGASQIY AGYTCSFAVS EVGGLFFWGA TNTSRESTMY 
PKAVQDLCGW RIRSLACGKS SIIVAADEST ISWGPSPTFG ELGYGDHKPK SSTAAQEVKT 
LDGIFSEQVA MGYSHSLVIA RDESETEKEK IKKLPEYNPR TL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RCC2

Associated with

Other Information

The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression. PubMed ID: 12919680

Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10819331

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Telophase disc: a new mammalian mitotic organelle that bisects telophase cells with a possible function in cytokinesis. PubMed ID: 1939370

Delay of HeLa cell cleavage into interphase using dihydrocytochalasin B: retention of a postmitotic spindle and telophase disc correlates with synchronous cleavage recovery. PubMed ID: 7559776

Colocalization of TD-60 and INCENP throughout G2 and mitosis: evidence for their possible interaction in signalling cytokinesis. PubMed ID: 9914378

Functional proteomic analysis of human nucleolus. PubMed ID: 12429849

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

TD-60 is required for interphase cell cycle progression. PubMed ID: 23388455

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure. PubMed ID: 25074804

TD-60 links RalA GTPase function to the CPC in mitosis. PubMed ID: 26158537

RCC2 is a novel p53 target in suppressing metastasis. PubMed ID: 28869598